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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using multigated radionuclide ventriculography (RNV), the left ventricular (LV) phase histogram (PH) was used to quantitate LV synchrony at rest and at submaximal and maximal supine exercise in 10 normal and 10 coronary (CAD) patients. Each LV PH was obtained by masking the phase image with an LV region, generated semiautomatically and modified if necessary to minimize ambiguity of LV delineation. The shape and spread of each histogram was characterized by its standard deviation (SD) and skewness (SK). Normals had a tight resting PH with slight negative skewness (SD = 9.06 +/- 0.22 (mean +/- SEM; SK = -0.53 +/- 0.05). CAD patients had a wider resting PH with a larger SD and a significantly more positive skewness reflecting greater contractile asynchrony (SD = 16.53 +/- 2.26; SK = 0.35 +/- 0.22). With exercise the PH distribution for the normals remained tight (SD = 8.1 +/- 0.24) while SK changed little (SK = -0.29 +/- 0.04). In contradistinction, with exercise CAD patients markedly increased the spread of their LV PH (SD = 27.42 +/- 3.77) and increased the number of late pixels (SK = 0.75 +/- 0.15). It is concluded that quantitative PH analysis is a useful adjunct for the analysis of regional asynergy during resting or exercise radionuclide left ventriculography.
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PMID:Quantitative phase analysis of exercise radionuclide left ventriculography in normals and patients with coronary artery disease. 683 32

While spatial asynergy at end-systole has been well characterized in patients with coronary artery disease, assessment of regional asynchrony has been hampered by technical constraints. We developed a computer-assisted method for analyzing regional asynchrony from the equilibrium (ECG-gated) radionuclide ventriculogram. Twenty patients with normal contrast left ventriculograms (nine with a normal coronary arteriogram [group 1] and 11 with coronary artery disease [group 2]) and 20 patients with asynergy during contrast ventriculography (group 3) were studied. The earliest evidence of regional asynchrony occurred in early systole. Regional ejection fraction at one-third systole was 0.32 +/- 0.02 (mean +/- SEM) in group 1, 0.22 +/- 0.01 in group 2 (p less than 0.001) and 0.12 +/- 0.01 in asynergic regions in group 3 patients (p less than 0.001). In group 3, severe forms of regional asynchrony appeared in both early systole and early diastole: five patients (25%) had early systolic paradox, 13 (65%) had regional prolongation of peak ejection fraction and 16 (80%) had reduced percent peak ejection fraction at global end-systole. It appears, therefore, that there is progressively increasing regional asynchrony in patients with increasing severity of coronary artery disease.
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PMID:Disruption in the temporal sequence of regional ventricular contraction. I. Characteristics and incidence in coronary artery disease. 737 Nov 20