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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic lung disease that requires prolonged oxygen therapy commonly complicates the recovery of extremely low-birth-weight infants (less than 1000 g). We report follow-up data through 18.5 +/- 0.9 (mean +/- SEM) months of age in 30 extremely low-birth-weight infants (birth weight, 783 +/- 24 g; gestational age, 26.0 +/- 0.3 weeks) who were discharged home receiving supplemental oxygen. Oxygen was prescribed to maintain arterial oxygen saturation at 95% or greater. At discharge, postconceptional age was 40.5 +/- 0.6 weeks, and weight was 2220 +/- 50 g. Duration of home oxygen therapy was 4.5 +/- 0.5 months. The mean weight percentile increased from less than 5 to 23 between discharge and the last follow-up. All infants survived; only 6 required hospitalization for acute medical illnesses. We conclude that carefully supervised home oxygen therapy permits the safe early discharge of selected extremely low-birth-weight infants with chronic lung disease.
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PMID:Home oxygen therapy for chronic lung disease in extremely low-birth-weight infants. 291 12

Chronic lung disease in infants continues to be problematic. Tidal liquid ventilation (TLV) improves lung mechanics and provides effective gas exchange. We hypothesized that premature lambs could be supported safely with TLV and evaluated 9 preterm lambs (132 days gestation) on TLV up to 72 h. Results (mean +/- SEM): pH 7.36 +/- 0.003, PaCO2 44 +/- 0.34 mm Hg, PaO2 170 +/- 4.8 mm Hg, compliance=1.65 +/- 0.24 ml/cm H2O/kg, mean arterial blood pressure=53 +/- 0.08 mm Hg, heart rate=189 +/- 1.5 bpm. Blood perflubron levels were 6.0 +/- 0.24 microg/ml over 24 h. Tissue perflubron levels increased from 81 +/- 7.0 microg/g at 24 h to 108 +/- 15 microg/g at 72 h (p<0.05). There was a difference in perflubron concentrations as a function of tissue (p<0.001) that correlated to lipid levels (r2=0.93, p<0.01). These data demonstrate that TLV is both safe and effective up to 72 h in premature lambs.
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PMID:Long-term tidal liquid ventilation in premature lambs: physiologic, biochemical and histological correlates. 1450 47