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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyperosmolal feedings have been implicated as a cause of potential disruption to the physiology of the neonatal intestinal tract. To evaluate this we studied eight awake lambs (11 +/- 2 days old) with chronically implanted catheters in the portal sinus, descending aorta, and left and right ventricles. Blood flow (Q) was calculated with the radionuclide-labeled microsphere technique and O2 delivery (DO2) and consumption (VO2) by the Fick principle using blood O2 contents. Lambs were studied initially after a 4-h fast and sequentially at 2, 3, and 4 h after eating a hyperosmolal (590 mOsmol) formula. Cardiac output (mean +/- SEM, 332 +/- 22 ml.min-1.kg-1) and whole animal VO2 (16.5 +/- 2.5 ml O2.min-1.kg-1) remained stable. Total gastrointestinal (GI) blood flow increased 28% by 3 h. Small intestine Q increased 21% 3 h after feeding and then returned to baseline. Similarly, large intestinal Q increased 77% after feeding and remained elevated. There was no effect on stomach Q. Total GI vascular resistance fell 28% 3 h after feeding then returned to baseline. DO2 to the GI tract increased at 3 h and returned to baseline. There was no change, though, in GI VO2 (3.9 +/- 0.4 ml O2.min-1.100 g-1) or in the extraction (VO2/DO2) of oxygen (21.2 +/- 1.8%) during the study. Furthermore, there was no evidence for GI tract acidosis at any time. Systemic organ blood flow (except hepatic arterial blood flow) remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Hyperosmolal feedings and gastrointestinal blood flow and oxygenation in newborn lambs. 343 Feb 69

Small intestine submucosa (SIS) has been reported as an excellent biomaterial for tissue engineering because of its naturally occurring collagenous extracellular matrix property with growth factors. However, SIS from submucosal layer of intestine provides different microenvironment from bone tissue, which limits its application to bone regeneration. The object of this study was to improve osteoinductivity of SIS by controlled local delivery of icariin (Ic), a potent osteogenic compound. Sustained release of icariin from SIS scaffold was achieved for >30days and the loading of icariin on SIS scaffold was uniform as scanned by SEM. In vitro experiments revealed that expression of osteogenic differentiation markers (Alp, Bsp and Ocn) was increased after treatment of Ic-SIS scaffold, without significant cytotoxicity. In an in vivo mouse calvarial defect model, bone regeneration was enhanced by SIS implantation at 8weeks, compared to control defect. New bone formation was further improved by implantation with Ic-SIS (low and high) at both 4 and 8weeks. The results of this study suggest that SIS scaffold has the potential as an icariin delivery carrier for enhancement of bone regeneration.
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PMID:Controlled delivery of icariin on small intestine submucosa for bone tissue engineering. 2798 7