Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The synaptic membrane glycoprotein D2 was measured in cerebrospinal fluid (CSF) and plasma in 13 patients with normal pressure hydrocephalus (NPH), in 14 patients with primary degenerative dementia of Alzheimer type (PDD), and in 24 patients without evidence of organic nervous disease (controls). Mean CSF D2 concentration was significantly lower in NPH patients: 299 +/- 48 ng/ml (SEM) (P less than 0.001) than in PDD patients: 658 +/- 50 ng/ml (SEM) and in controls 641 +/- 45 ng/ml (SEM). Plasma D2 concentrations were higher in PDD patients compared with those found in controls. Determination of CSF D2 concentrations might be of diagnostic value in discrimination between patients with NPH and PDD patients with enlarged ventricles associated with diffuse brain atrophy.
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PMID:Low cerebrospinal fluid concentration of brain-specific protein D2 in patients with normal pressure hydrocephalus. 666 78

A study of 72 alcoholics, hospitalized for alcohol withdrawal syndrome, was undertaken to determine the incidence of seizures, their relationship with other withdrawal symptoms, the presence of brain atrophy and the relationship of this last with withdrawal intensity severity. Sixty-seven (93%) were male and the mean age was 44.9 +/- 1.3 (mean +/- SEM) years. Thirty-three (46%) of the 72 patients had seizures at admission, 10 of these developed minor withdrawal symptoms, in 18 delirium tremens ensued and 5 showed no symptoms of withdrawal. Thirty-nine (54%) had withdrawal syndrome without seizures. Twenty-one of these developed minor withdrawal syndrome and 18 delirium tremens. Seizures showed no relationship with the other withdrawal manifestations, and in all the cases preceded them. Our findings also show that alcoholics with seizures due to withdrawal are more prone to suffer seizures in their future withdrawal episodes, and that alcoholics who suffer morning withdrawal symptoms are prone to develop delirium tremens. In 46 patients a CT scan was performed. Though the alcoholics showed ventricular and sulcal enlargement, brain atrophy was similar when the seizure and non-seizure groups or those with and without delirium tremens were compared. However, cortical and ventricular atrophy were related to the existence of previous episodes of withdrawal syndrome [corrected].
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PMID:Alcoholic withdrawal syndrome and seizures. 794 73

We presented an up-to date flow chart for the diagnosis and treatment of brain metastasis and described the characteristics of brain metastases from various organs in 390 patients with metastatic brain tumors treated at the Osaka Medical Center for Cancer & Cardiovascular Disease from 1977 to 1994. In the treatment of 287 brain metastases from lung cancer, the mean survival time (MST) was significantly longer in the surgical group and the chemotherapy group, compared with that in the non-surgical group and the non-chemotherapy group, while the radiation group did not show longer MST than the non-radiation group. Of 17 patients surviving longer than 2 years after the treatment of brain metastases from lung cancer, 11 patients had undergone brain surgery and chemotherapy, and all 5 patients who survived longer than 5 years had been treated with surgical excision and chemotherapy, mainly with CDDP. Fifty-seven patients with neither primary cancer nor extracranial cancer lesions survived the longest after brain surgery (Mean +/- SEM: 824 +/- 140 days). Data obtained in the analysis of brain metastases from lung cancer were also compared with the 20 reports of stereotactic radiosurgical treatment (SRT). The 1-year survival rate (mean, n: 26.7%, 3 reports) and survival time (mean, n: 7.4 months, 6 reports) in SRT without whole brain irradiation was similar to that in the direct surgical excision group (mean: 26.5%, 9.0 months). From these findings, we reached a consensus that SRT plays a part in direct surgical excision in cases of tumors less than 3.0 cm in diameter, and that brain metastases should be treated basically with SRT or direct surgical resection combined with systemic chemotherapy. If radiation therapy is added, small doses are preferred to prevent brain atrophy.
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PMID:[Diagnosis and treatment of metastatic brain tumor]. 883 34

The relationship between monocyte immune responses and cognitive impairment during progressive human immunodeficiency virus type 1 (HIV-1) infection was investigated in 28 subjects receiving highly active antiretroviral therapy. The mean+/-SEM CD4(+) T lymphocyte count and virus load for all patients were 237+/-41 cells/mm(3) and 77,091+/-195,372 HIV-1 RNA copies/mL, respectively. Levels of soluble tumor necrosis factor-alpha type II receptor (sTNF-RII) and soluble CD14 (sCD14) were measured in plasma by ELISA and were correlated with results from neuropsychological, magnetic resonance imaging, and magnetic resonance spectroscopy tests. Plasma sCD14 and sTNF-RII levels were elevated in subjects with cognitive impairment and in those with brain atrophy. Furthermore, both factors were correlated with spectroscopic choline:creatine ratios. These findings support the idea that peripheral immune responses are linked to cognitive dysfunction during advanced HIV-1 disease.
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PMID:Plasma levels of soluble CD14 and tumor necrosis factor-alpha type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection. 1151 30