Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Duodenogastric reflux has been implicated in the pathogenesis of gastric mucosal disease but the relative toxicities of its constituents are not known. The suitability of the ex vivo rat gastric chamber model for systematic studies of bile acid gastrotoxicity was assessed using deoxycholic acid (DCA 0.2-5.0 mmol/l). Acute challenge with 5.0 mmol/l DCA produced significant loss of gastric transmucosal potential difference (delta PD = 25.9 +/- 3.3 mV: mean +/- SEM; p less than 0.01) compared with saline challenge (1.5 +/- 0.5 mV). Significant delta PD values were produced by DCA concentrations down to 0.5 mmol/l (16.0 +/- 2.8 mV). Challenge with 5.0 mmol/l DCA also caused significant increases in chamber fluid concentrations of nucleic acid (2.8 +/- 0.3 micrograms/ml; p less than 0.05) and acid phosphatase (130 +/- 23.4 microU/ml; p less than 0.01). This study demonstrates DCA gastrotoxicity at concentrations comparable to human intragastric total bile acid concentrations and the suitability of this model for studying the toxic components of refluxed duodenal contents.
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PMID:Is the ex vivo rat gastric chamber model suitable for studying the gastrotoxicity of refluxed duodenal contents? Initial results using deoxycholic acid. 324 Jun 4

Duodenogastric reflux was assessed scintigraphically in normal subjects (n = 20) and in patients with duodenal (n = 15) or gastric ulcers (n = 14). Reflux was graded 0-4 according to degree and was minimal in the control group (0.25 +/- 0.12) (mean +/- SEM), but significantly increased in 11 out of 15 patients with duodenal ulceration (1.33 +/- 0.25) and in 12 out of 14 patients with gastric ulceration (1.86 +/- 0.29) (P less than or equal to 0.0025). Gastric mucosal biopsies taken at endoscopy showed changes of gastritis which correlated well with the degree of reflux. It is suggested therefore that duodenogastric reflux may play a significant role in the pathogenesis of some peptic ulcers, and may be responsible for many of the pathophysiological changes seen in these patients.
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PMID:The possible role of duodenogastric reflux in the pathogenesis of both gastric and duodenal ulcers. 658 5

Fifty-seven patients undergoing routine or review gastroscopy had multiple gastric biopsies taken and assessed histologically for gastritis, metaplasia and dysplasia. Duodenogastric reflux was graded scintigraphically by BIDA Scanning. Patients with dysplastic changes in the gastric mucosa (n = 33) had a higher mean grade of reflux 2.1 +/- 0.21 (mean +/- SEM) than patients with no dysplasia (1.1 +/- 0.24: P less than 0.0025). Patients with metaplasia (n = 33) had an increased mean grade of reflux of 2.0 +/- 0.19 compared with patients without metaplasia (1.3 +/- 0.29: P less than 0.05), but there was no significant difference in degree of reflux between patients with and without gastritis. When the grade of reflux was plotted against increasing degrees of mucosal abnormalities, there appeared to be a positive correlation between duodenogastric reflux and severity of mucosal change.
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PMID:The clinical assessment of duodenogastric reflux by scintigraphy and its relation to histological changes in gastric mucosa. 658 12