Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0426980 (motor symptom)
 471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
SYNGR4 16.0
PLEKHB1 13.2
DPYSL2 10.8
PDE1B 10.4
LPD 10.3
SOX-10 10.2
AIFM1 10.2
REP1 9.9
HCN3 9.9
OMD 9.8
STN 9.6
DBS 9.4
ddc 9.3
PPX 9.0
with Parkinsonism 9.0
ATP1A3 8.9
PRG 8.8
ATP1A2 8.8
LCE 8.6
PDE4A 8.5
Dopamine transporter 8.5
GluR-A 8.4
G protein-coupled estrogen receptor 1 8.4
leucine-rich repeat kinase 2 8.3
MDS 8.2
ubiquitin C-terminal hydrolase 8.2
CMAP 8.2
SNCA 8.2
alpha-synuclein 7.9
mitogen-activated protein kinase kinase kinase 7.9
HTT 7.8
LRRK2 7.7
TARDBP 7.7
SLC2A1 7.7
MuSK 7.7
IDS 7.6
TH protein 7.5
AMR 7.5
synuclein 7.5
CACNA1A 7.4
G15 7.4
ADAS 7.4
MSA 7.3
DJ-1 7.3
GDS 7.3
H-Y 7.3
MTR 7.2
CIT 7.2
PSEN1 7.2
CTRL 7.1
GLT-1 6.8
Phosphodiesterase 6.8
SCN1A 6.8
5-HT2B 6.8
dopamine transporter 6.7
huntingtin 6.7
superoxide dismutase 1 6.7
PINK1 6.7
Arnt 6.7
parkin 6.7
P200 6.6
ChAT 6.6
CDT 6.6
PCS 6.5
DAT 6.5
Dance 6.5
PDC 6.4
retino 6.4
PND 6.4
Huntingtin 6.4
neurogranin 6.4
catechol-O-methyltransferase 6.3
TDP-43 6.2
AChR 6.2
GAF 6.2
insulin-like growth factor II 6.1
BIS 6.1
vesicular monoamine transporter 2 6.1
dopa decarboxylase 6.0
GDNF 6.0
HSP60 6.0
MEKK 6.0
translocator protein 5.9
CA4 5.9
FPL 5.9
TMS 5.9
calcium-sensing receptor 5.8
fatty acid amide hydrolase 5.8
CGI 5.7
Transferrin 5.7
cAMP response element binding protein 5.7
Clock 5.6
SOD1 5.6
interleukin 10 5.6
apoptosis-inducing factor 5.5
CB1 5.4
brain-derived 5.4
AES 5.3
MPP 5.3
ADL 5.3
Nestin 5.2
Apolipoprotein E 5.2
monocyte chemoattractant protein 5.2
GAD 5.2
REM 5.2
leukemia inhibitory factor 5.1
MDP 5.1
asymmetrical 5.1
phosphatase and tensin homolog 4.9
Epidermal growth factor 4.9
olfactory 4.8
dopamine D2 receptor 4.8
PSD-95 4.8
glutamate transporter 4.7
MAO-B 4.7
tau protein 4.7
CB2 4.7
NR1 4.7
dream 4.6
GLUT1 4.5
ACP 4.5
ghrelin 4.4
arrestin 4.4
ALS 4.3
5-HT2A 4.3
VIP 4.3
TAT 4.3
cannabinoid receptor 4.2
orexin 4.2
SNAP 4.2
tyrosine hydroxylase 4.1
CYP2D6 4.1
neuronal nitric oxide synthase 3.9
neurotensin 3.9
prion 3.8
neurotrophic factor 3.8
RNA-binding protein 3.8
vasoactive intestinal peptide 3.8
vitamin D receptor 3.8
interleukin 6 3.7
CCL2 3.7
CA3 3.6
GABA(A) receptor 3.6
sit 3.6
ankylosing spondylitis 3.6
neurotrophin 3.5
axonal 3.4
muscarinic receptor 3.4
MRI 3.4
CREB 3.4
tap 3.3
arginine vasopressin 3.3
glucose transporter 3.2
prion protein 3.2
5-hydroxytryptamine 3.2
PTEN 2.9
phosphodiesterase 2.9
nuclear receptor 2.9
acetylcholinesterase 2.6
FDG 2.6
CSF 2.5
cyclooxygenase-2 2.5
extracellular signal-regulated kinase 2.5
mTOR 2.4
chronic renal failure 2.3
androgen receptor 2.3
GTPase 2.2
TGF-beta 2.2
brain-derived neurotrophic factor 2.2
VEGF 2.1
amyloid precursor protein 1.9
San 1.9
gut 1.9
She 1.9
transferrin 1.9
osteogenic 1.8
substance P 1.7
ANOVA 1.6
CA1 1.5
SDS 1.4
glucagon 1.4
estrogen receptor 1.3
hole 1.2
hemoglobin 1.1
Bcl-2 1.0
GABA 1.0
IFN 0.6
caspase-3 0.6
catalase 0.5
CD8 0.4
interferon 0.1
Sep -0.2
CD4 -0.2
ACS -0.2
Mol -0.4
ATP -1.0
cytokine -1.1
NMR -1.2
insulin -1.6
Disease
Motor Disorders 13.2
Hypokinetic dysarthria 13.0
Orofacial dyskinesia 12.3
Bowel dysfunction 11.0
Speech impairment 10.7
taste disorder 9.7
Corticobasal degeneration 9.3
REM sleep behavior disorder 9.2
FFS 9.0
impulse control disorder 8.8
gastrointestinal dysfunction 8.8
Stereotypy 8.7
behavior disorder 8.7
hemiparkinsonism 8.6
Parkinson's disease 8.6
reflex epilepsy 8.6
hemiplegic migraine 8.5
Sleep disturbance 8.4
Multiple system atrophy 8.3
Chronic inflammatory demyelinating polyradiculoneuropathy 8.2
sirenomelia 8.2
MDS 8.1
neuromyotonia 8.1
movement disorder 8.1
cognitive disorder 8.0
SAPHO syndrome 8.0
dyskinesia 7.9
tarsal tunnel syndrome 7.9
parasomnia 7.6
hysteria 7.6
Huntington's disease 7.5
Essential tremor 7.4
speech disorder 7.3
CDT 7.3
MSA 7.3
parkinsonism 7.2
dysautonomia 7.2
CES 7.2
BPS 7.1
Li-Fraumeni syndrome 7.1
incontinentia pigmenti 7.0
sleep disturbances 6.8
restless legs syndrome 6.7
abnormal involuntary movements 6.7
Frey 6.7
Dystonia 6.6
sleep disorders 6.6
PCS 6.5
dysphasia 6.5
akinesia 6.5
Spinocerebellar ataxia 6.4
multiple disorders 6.4
PDC 6.4
DWI 6.4
Dementia with Lewy bodies 6.4
PND 6.3
polyradiculoneuropathy 6.3
Guillain-Barre syndrome 6.3
nerve entrapment 6.3
osteosclerosis 6.3
alopecia areata 6.2
hallucinations 6.2
trichotillomania 6.1
self-injurious behavior 6.1
intellectual impairment 6.1
endometrial stromal sarcoma 6.0
conversion reaction 6.0
mutism 5.9
progressive supranuclear palsy 5.9
stereotypies 5.9
ICC 5.9
nerve lesion 5.8
ICC 5.8
cognitive impairment 5.8
nocturia 5.8
seborrheic dermatitis 5.7
brain dysfunction 5.6
PDD 5.6
degenerative disease 5.6
motor neuron disease 5.5
Fox 5.5
myelodysplastic syndrome 5.5
dementia 5.5
brain atrophy 5.4
carotid artery stenosis 5.3
hyperostosis 5.3
amyotrophic lateral sclerosis 5.3
cardiovascular risk factor 5.1
clinical depression 5.0
sexual dysfunction 5.0
psychiatric diagnosis 4.9
aspiration pneumonia 4.9
thymoma 4.9
carpal tunnel syndrome 4.9
panic attacks 4.8
cognitive deficit 4.8
Wilson's disease 4.8
GAD 4.8
myasthenia gravis 4.7
Bladder 4.7
Bladder 4.7
Bladder 4.7
narcolepsy 4.7
amblyopia 4.7
anhedonia 4.7
Syndrome 4.7
depression 4.7
optic neuritis 4.6
HAM 4.6
apraxia 4.6
valvular heart disease 4.6
tetraplegia 4.5
ACP 4.5
Charcot-Marie-Tooth disease 4.5
neurological disease 4.5
Cannabis 4.4
tic 4.4
Tourette syndrome 4.4
hyperhomocysteinemia 4.4
Rett syndrome 4.3
chronic pain 4.1
dysphagia 4.1
sleep apnea 4.1
psychosis 4.0
myocarditis 4.0
xerostomia 4.0
anxiety disorders 3.7
multiple sclerosis 3.7
varices 3.6
vitamin D deficiency 3.6
migraine 3.6
affective disorder 3.6
ARF 3.5
delirium 3.5
psychological stress 3.4
ankylosing spondylitis 3.4
NAME 3.3
erectile dysfunction 3.3
schwannoma 3.2
memory impairment 3.2
status epilepticus 3.2
cerebral infarction 3.2
respiratory failure 3.2
neuropathy 3.1
obsessive-compulsive disorder 3.1
muscular atrophy 3.1
Alzheimer's disease 3.0
schizophrenia 3.0
systemic disease 3.0
Blocking 2.9
encephalitis 2.9
cerebral palsy 2.8
peripheral neuropathy 2.7
encephalomyelitis 2.4
Autism 2.3
myelopathy 2.3
mental illness 2.1
fits 2.1
epilepsy 2.1
autism 2.1
rash 2.0
chronic disease 1.9
major depressive disorder 1.6
chronic renal failure 1.6
SDS 1.4
immunodeficiency 0.9
gastric cancer 0.9
osteoporosis 0.8
systemic lupus erythematosus 0.6
rheumatoid arthritis 0.3
colorectal cancer 0.3
cardiovascular disease 0.0
heart failure -0.1
West -0.1
hypertension -0.3
cold -0.4
diabetes -1.0
stroke -1.1
cancer -3.0
Symptom
motor symptom 16.0
dribbling saliva 15.0
Dellen 13.5
Swallowing problems 10.5
bradykinesia 10.4
Visual symptoms 9.2
chorea 8.5
Involuntary Movement 8.4
visual hallucination 7.9
mental fatigue 7.9
tremor 7.7
drooling 7.7
apathy 7.6
eds 7.6
muscle rigidity 7.6
catatonia 7.5
blepharospasm 7.0
abnormal gait 6.9
dystonia 6.8
Fluctuation 6.8
limb pain 6.7
forgetfulness 6.6
constipation 6.6
Depressive symptoms 6.1
sleepiness 6.0
dysarthria 5.8
myoclonus 5.6
anosmia 5.5
photophobia 5.4
bloating 5.3
alexithymia 5.3
cerebellar ataxia 5.2
neck pain 5.1
spasticity 5.0
paresthesia 4.8
fatigue 4.6
insomnia 4.3
hemiplegia 4.1
weakness 4.0
cachexia 3.6
hypotonia 3.5
pain 3.4
spasm 3.2
nausea 3.1
ataxia 3.1
dizziness 2.8
thinning 2.6
stigma 2.3
seizures 2.3
chest pain 2.0
headache 1.9
analgesia 1.3
Drug
Permax 13.2
Permax 13.2
Fluvoxamine maleate 12.2
Fluvoxamine maleate 11.5
Rotigotine 10.4
Rasagiline 9.8
Carbidopa 9.7
DBS 9.4
Pramipexole 9.4
Pramipexole 9.3
Tapentadol 9.2
Vardenafil 8.6
MDS 8.2
Sinemet 8.0
Duloxetine 7.8
Domperidone 6.6
Gabapentin 6.2
Oxaliplatin 6.2
TMS 5.9
9-THC 5.3
Amiloride 5.2
TTC 5.2
Spectrum 5.1
Frontal 5.0
Spectrum 4.0
Posture 3.6
ROC 3.1
CSF 2.1
caffeine 1.6
Enzyme
phosphatidylinositol-4,5-bisphosphate 3-kinase 8.4
DOPA decarboxylase 7.0
isopeptidase 6.9
DAT 6.5
Pla 6.2
botulinum neurotoxin 6.2
BIS 6.1
tyrosine aminotransferase 5.7
MEKK1 5.2
MPP 5.2
MDP 4.7
tyrosine hydroxylase 4.2
monoamine oxidase 3.7
complex I 2.9
phosphodiesterase 2.8
acetylcholinesterase 2.8
cholinesterase 2.4
caspase-3 0.9
catalase 0.3
ACS -0.2
protein kinase -0.3
ERK -0.5
mitogen-activated protein kinase -0.5
Compound
Carbidopa-levodopa 13.0
S 10 10.8
Meclizine 10.5
PDQ 10.1
DBS 9.4
1,2,3,6-tetrahydropyridine 9.2
1,2,3,6-tetrahydropyridine 9.2
Tetrabenazine 9.2
Edaravone 7.7
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 7.6
MPTP 7.5
CDT 7.3
CES 7.2
Crocin 7.2
L-DOPA 7.1
MEGA 6.8
R 2 6.5
DAT 6.5
Rotenone 6.4
AEA 6.4
Yohimbine 6.1
Valproic acid 6.0
AEA 5.7
CIT 5.6
CIT 5.6
Amide 5.5
MPP 5.3
Dopa 5.3
MPP 5.2
Stimul 5.1
Dopamine 4.9
TTC 4.9
Neo 4.4
Valproic acid 4.3
EDS 4.3
Histone 3.8
Morphine 3.7
PAS 3.4
noradrenaline 3.4
Vitamin D 3.3
Off 3.3
Neurotol 3.2
gamma-aminobutyric acid 3.1
5-HT 3.1
DSM 2.9
GMP 2.9
isopropanol 2.8
CAT 2.8
aspartic acid 2.4
uridine 2.4
pyrimidine 1.8
pyrimidine 1.7
cGMP 1.7
caffeine 1.6
SDS 1.3
vitamin D 1.3
proline 1.1
nitric oxide 1.0
GABA 1.0
manganese 1.0
GABA 0.9
glutamate 0.9
acetate 0.8
glycerol 0.7
potassium 0.5
Dec 0.2
Clin 0.1
iron -0.0
alanine -0.1
galactose -0.1
glucose -0.2
ACS -0.2
ACS -0.2
sodium -0.5
copper -0.5
tyrosine -0.5
calcium -0.7
sulfate -0.7
salt -0.8
ATP -1.0
hydrogen -1.6
water -1.8
oxygen -2.4
DNA -3.6