Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0426980 (
motor symptom
)
471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
27
synuclein
15
alpha-synuclein
15
olfactory
15
MRI
13
MDS
10
LPD
10
DBS
9
STN
8
dopamine transporter
7
axonal
7
Mol
7
asymmetrical
6
huntingtin
5
gut
4
tyrosine hydroxylase
4
SNCA
3
LRRK2
3
She
3
leucine-rich repeat kinase 2
3
more...
Disease
Parkinson's disease
360
depression
64
dementia
37
Huntington's disease
36
parkinsonism
31
cognitive impairment
30
dyskinesia
19
movement disorder
18
Alzheimer's disease
13
amyotrophic lateral sclerosis
11
myelodysplastic syndrome
10
sleep disorders
10
MDS
10
sleep disturbances
9
hallucinations
8
multiple sclerosis
8
psychosis
7
schizophrenia
7
behavior disorder
6
chronic pain
5
more...
Symptom
motor symptom
471
tremor
58
bradykinesia
47
pain
41
fatigue
18
constipation
15
dystonia
14
apathy
12
sleepiness
12
chorea
11
weakness
9
seizures
6
eds
3
nausea
3
myoclonus
3
spasticity
3
muscle rigidity
3
catatonia
3
dysarthria
3
insomnia
3
more...
Drug
MDS
10
DBS
9
Spectrum
4
Sinemet
2
Rotigotine
2
Pramipexole
2
Rasagiline
2
CSF
2
TMS
2
Pramipexole
2
Carbidopa
2
Gabapentin
1
Fluvoxamine maleate
1
Domperidone
1
Vardenafil
1
9-THC
1
caffeine
1
Posture
1
TTC
1
Duloxetine
1
more...
Enzyme
tyrosine hydroxylase
4
acetylcholinesterase
3
phosphodiesterase
2
DAT
2
monoamine oxidase
2
DOPA decarboxylase
2
botulinum neurotoxin
2
MPP
1
ERK
1
isopeptidase
1
Pla
1
BIS
1
caspase-3
1
phosphatidylinositol-4,5-bisphosphate 3-kinase
1
cholinesterase
1
mitogen-activated protein kinase
1
MEKK1
1
protein kinase
1
catalase
1
ACS
1
more...
Compound
Dec
37
Clin
24
L-DOPA
19
MPTP
14
DBS
9
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9
PDQ
7
noradrenaline
5
5-HT
4
Dopamine
4
glucose
4
CES
3
acetate
3
calcium
3
DSM
3
sodium
3
nitric oxide
3
water
3
CIT
2
1,2,3,6-tetrahydropyridine
2
more...