Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0426980 (
motor symptom
)
471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The present study reported the efficacy of antisense oligonucleotides specific for N-methyl-D-aspartate receptor one (
NR1
) in reduction of
motor symptom
in a rat parkinsonian model, the unilateral 6-hydroxydopamine-lesioned rat. Significant reductions in apomorphine-induced contralateral rotation were only seen in the
NR1
antisense-treated lesioned rats (after a single intraparenchymal dose of antisense to the lesioned neostriatum; 15 nmol in 3 microl of saline) at 1 or 2 days after the treatment. No motor effect was seen in the lesioned animals with control treatments (sham, treatment using
NR1
sense oligonucleotides, randomized oligonucleotides or saline, respectively). In contrast, significant increases in expression of
NR1
mRNA in the lesioned neostriatum were seen in rats with control treatments but not in rats with
NR1
antisense treatment. Importantly, in the lesioned neostriatum that was treated with
NR1
antisense, a significant reduction in
NR1
protein expression was found and
NR1
immunoreactivity was seen to reduce in perikarya of presumed striatal medium spiny neurons. The present data indicate that a single dose of
NR1
antisense ameliorates
motor symptom
in the rat model. The efficacy of
NR1
antisense is likely to be mediated by a selective knockdown in expression of
NR1
mRNA and proteins in the presumed medium spiny neurons.
...
PMID:Selective knockdown of gene expression of N-methyl-D-aspartate receptor one ameliorates parkinsonian motor symptom in 6-hydroxydopamine-lesioned rats. 1508 17
