Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0423716 (Neuropathic pain)
 1,417 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 97
Mol 96
TNF 63
cytokine 59
IL-6 55
tumor necrosis factor 37
GABA 36
brain-derived neurotrophic factor 28
opioid receptor 26
IL-10 26
ATP 25
glial fibrillary acidic protein 23
p38 21
NMDA receptor 21
substance P 20
DRG 20
axonal 19
P2X 18
interleukin-6 18
inducible nitric oxide synthase 17
sodium channel 17
calcium channel 17
TRPV1 17
CCL2 15
SNS 13
MAPK 13
chemokine 13
calcitonin 12
P2X4 12
ERK1 11
TLR4 11
ERK 10
p38 mitogen-activated protein kinase 10
nerve growth factor 9
signal transducer and activator of transcription 3 9
catenin 8
voltage-gated sodium channel 8
mTOR 8
CCR2 8
TRPA1 8
tumor necrosis factor alpha 8
JNK 8
nitric oxide synthase 8
CGRP 8
STAT3 8
histone 8
lipopolysaccharide 8
IL-1 7
p65 7
TRPM8 7
caspase-3 7
KCC2 7
membrane-bound 7
PI3K 6
COX2 6
NR2B 6
interleukin-10 6
neuronal nitric oxide synthase 6
p38MAPK 6
CB1 6
corticotropin-releasing factor 6
B12 6
cannabinoid receptor 6
neurotrophic factor 6
superoxide dismutase 6
NR1 6
matrix metalloproteinase 5
HCN2 5
histone deacetylase 5
glial cell line-derived neurotrophic factor 5
PARP 5
endoplasmic reticulum 5
COX-2 5
glutamic acid decarboxylase 5
CB2 5
P2X3 5
Nav1.7 5
NGF 5
dynorphin 5
Iba1 5
GSH 5
ionotropic 5
MRI 4
neuropeptide Y 4
SNL 4
T10 4
L-type calcium channel 4
mitogen-activated protein 4
IL-1ra 4
CD86 4
Calcitonin 4
transient receptor potential vanilloid 1 4
C-C 4
IL-18 4
cage 4
Janus kinase 4
MMP-9 4
tyrosine kinase 4
myelin basic protein 4
CXCL1 4
mu opioid receptor 4
CC chemokine receptor 4
Janus kinase 2 4
gut 4
UTR 3
interferon 3
WIN 3
G9a 3
catalase 3
RANTES 3
P2X7 3
fractalkine 3
PKC 3
TNF-alpha 3
CCR5 3
Nav1.3 3
TRP 3
REST 3
CREB 3
SIRT1 3
glutamate receptor 3
HCN1 3
SCI 3
EP1 3
ADP 3
membrane protein 3
nodal 3
fibronectin 3
renin 3
interleukin 6 3
NK1 3
5-HT1A 3
chemokine receptor 3
GAD65 3
CA1 3
MMP-2 3
activating transcription factor 3 3
cyclooxygenase 2 3
p62 3
Kv4.3 3
NKCC1 3
metabotropic glutamate receptor 3
c-Jun 3
parvalbumin 3
HT3 3
major histocompatibility complex 3
VEGF 3
IL-2 3
IFN 3
erythroid 3
CXCR4 3
ACS 3
CC chemokine 3
IL6 3
CXCL12 3
Pol 3
SOCS3 3
NR2A 3
monocyte chemoattractant protein-1 3
olfactory 3
more...
Disease
chronic pain 263
neuropathy 120
cancer 100
diabetes 93
cold 83
Frey 78
depression 69
peripheral neuropathy 58
postherpetic neuralgia 56
diabetic neuropathy 55
trigeminal neuralgia 37
multiple sclerosis 31
polyneuropathy 26
stroke 19
regional pain syndrome 17
HIV 17
tumor 16
nerve lesion 16
herpes zoster 14
mononeuropathy 14
disinhibition 13
chronic disease 12
neuroma 11
phantom limb pain 11
ischemia 11
AIDS 10
epilepsy 10
radiculopathy 9
addiction 8
neurological disease 8
autoimmune disease 8
migraine 8
sleep disturbances 7
encephalomyelitis 7
Blocking 7
carpal tunnel syndrome 6
osteoarthritis 6
leprosy 6
hypertension 6
breast cancer 5
Alzheimer's disease 5
GSH 5
confusion 5
cognitive impairment 5
fibromyalgia 5
hyperglycemia 4
Parkinson's disease 4
Complex regional pain syndrome 4
psychological distress 4
West 4
immunodeficiency 4
arthritis 4
physical dependence 4
memory impairment 4
obesity 3
myelopathy 3
sickle cell disease 3
hyperlipidemia 3
head and neck cancer 3
spinal cord compression 3
emotional distress 3
chronic obstructive pulmonary disease 3
Cannabis 3
type 1 diabetes 3
type 2 diabetes 3
substance abuse 3
metastases 3
asthma 3
sensory neuropathy 3
neuritis 3
sleep disorders 3
leg ulcers 3
rheumatoid arthritis 3
alcoholism 3
pruritus 3
Fabry 3
pertussis 2
intermittent claudication 2
nystagmus 2
causalgia 2
amyotrophic lateral sclerosis 2
phantom limb 2
SCS 2
immaturity 2
THC 2
neck cancer 2
herpes simplex 2
herpes 2
HIV neuropathy 2
fits 2
suicide 2
inguinal hernia 2
illusion 2
colon cancer 2
glucose intolerance 2
aggression 2
syringomyelia 2
uremia 2
myocardial infarction 2
peripheral vascular disease 2
affective disorder 2
neuroblastoma 2
Huntington's disease 2
diphtheria 2
xerostomia 2
anxiety disorders 2
Evans 2
NOD 2
cholera 2
psychological stress 2
GAD 2
anhedonia 2
NAME 2
plexopathy 2
cornea 2
glaucoma 2
skin disease 1
Fahr's disease 1
vaccinia 1
schizophrenia 1
peptic ulcer 1
dementia 1
solid tumor 1
alcohol abuse 1
tranquilizers 1
SARS 1
NPC 1
Hodgkin's disease 1
sepsis 1
CNS diseases 1
adenocarcinoma 1
lymphedema 1
amebiasis 1
vascular disease 1
nerve root compression 1
drug addiction 1
IVA 1
liver cancer 1
Burning mouth syndrome 1
ankylosing spondylitis 1
ICP 1
Adhesion 1
Guillain-Barre syndrome 1
Roth 1
PNS 1
PDB 1
autonomic neuropathy 1
PTP 1
monoarthritis 1
major depressive disorder 1
dyslipidemia 1
MIP 1
phlebitis 1
brachial plexopathy 1
EDA 1
ICD 1
Brown-Sequard syndrome 1
bipolar disorder 1
dysphagia 1
sepsis 1
more...
Symptom
Neuropathic pain 1417
pain 1349
analgesia 56
cancer pain 30
acute pain 27
headache 17
paresthesia 14
sleepiness 13
anesthesia 12
numbness 12
dizziness 11
dysesthesia 11
discomfort 10
orofacial pain 9
tingling 8
discomfort 8
back pain 8
low back pain 8
neuralgia 7
insomnia 7
nausea 6
weakness 5
tremor 5
bone pain 4
Peripheral neuropathic pain 4
dental pain 4
seizures 4
spasticity 4
ataxia 4
constipation 3
hyperesthesia 3
facial pain 3
functional recovery 3
nausea and vomiting 3
diarrhea 2
vomiting 2
collapse 2
despair 2
arthralgia 2
neck pain 2
sciatica 2
breakthrough pain 2
nerve pain 2
distraction 2
spasm 2
leg pain 2
Signs and Symptoms 2
fatigue 2
shoulder pain 2
vertigo 2
Mechanical pain 2
Chronic pelvic pain 1
peri-menopausal 1
incoordination 1
acute stress 1
Chronic chest pain 1
skin irritation 1
stump pain 1
Procedural pain 1
neurological pain 1
Involuntary Movement 1
dystonia 1
overweight 1
abdominal pain 1
asthenia 1
muscle cramps 1
pelvic pain 1
limb pain 1
myalgia 1
Other pain 1
fasciculation 1
Sympathetically maintained pain 1
forgetfulness 1
hunger 1
stigma 1
Wind 1
Deafferentation 1
Sedation 1
anorexia 1
Severe pain 1
Motor dysfunction 1
anosmia 1
No pain 1
chest pain 1
polydipsia 1
hypercapnia 1
respiratory distress 1
Somatic pain 1
angina 1
Visceral pain 1
Inflammatory pain 1
Drug
Gabapentin 20
Pregabalin 9
SNL 4
IL-1ra 4
9-THC 3
BoNT/A 3
Tapentadol 3
IL-2 3
Amiloride 2
Amiloride 2
MAP 2
Nephron 2
Vitamin B12 2
ICI 2
Duloxetine 2
CSF 2
BOTOX 2
Ziconotide 2
Taxol 2
Oxaliplatin 2
Domperidone 2
Clonidine 2
caffeine 2
Emodin 1
p75 1
Nitric Oxide 1
Vicodin 1
Vatalanib 1
lysine 1
DMAA 1
SMP 1
PMPA 1
NAG 1
Coix seed 1
DM1 1
Nitecapone 1
Benfotiamine 1
IFN-gamma 1
DMI 1
Gel 1
PDGF B-chain 1
Moclobemide 1
Diclofenac sodium 1
Fentanyl 1
ENT 1
Monit 1
Zonisamide 1
Bupivacaine 1
Salmon calcitonin 1
Donepezil 1
Ulinastatin 1
Mutagen 1
Namenda 1
Emodin 1
Diphenhydramine 1
Parecoxib 1
BH4 1
Nabilone 1
Triad 1
Simvastatin 1
IFN-beta 1
Piracetam 1
Naropin 1
EE2 1
Botox 1
ROS 1
Indomethacin 1
Nimesulide 1
Enzyme
mitogen-activated protein kinase 42
protein kinase 20
ERK 14
luciferase 13
protein kinase C 7
focal adhesion kinase 7
superoxide dismutase 6
PARP 6
caspase-3 5
MEK 4
botulinum neurotoxin 4
ACS 3
NADPH-diaphorase 3
renin 3
catalase 3
peroxidase 2
NO synthase 2
AMPK 2
SCS 2
AMPK 2
indoleamine 2,3-dioxygenase 2
DNA methyltransferase 2
AMP-activated protein kinase 2
reverse transcriptase 2
phosphodiesterase 2
kynurenine aminotransferase 1
NADPH oxidase 1
RNA polymerase 1
NOS 1
MIP 1
heme oxygenase 1
IKK 1
neutrophil elastase 1
ATPase 1
monoamine oxidase 1
Thy1 1
calcineurin 1
CPS 1
tyrosine hydroxylase 1
glutathione peroxidase 1
aldose reductase 1
phosphatidylinositol-4,5-bisphosphate 3-kinase 1
rhodopsin kinase 1
phospholipase C 1
CaMKII 1
trypsin 1
SST 1
SMP 1
IOR 1
acetylcholinesterase 1
glutathione reductase 1
beta-galactosidase 1
adenylate cyclase 1
glutamate decarboxylase 1
lysophosphatidylcholine acyltransferase 1
GSK 1
prostate-specific membrane antigen 1
glutathione S-transferase 1
PRE 1
TACE 1
CPN 1
glyceraldehyde-3-phosphate dehydrogenase 1
kynurenine 3-monooxygenase 1
tryptophan 2,3-dioxygenase 1
kynureninase 1
ATP synthase 1
elastase 1
NADPH oxidase 1
proteasome 1
histone-lysine N-methyltransferase 1
MAP 1
caspase-9 1
TSA 1
Compound
Dec 92
Clin 65
TNF 63
calcium 61
sodium 52
GABA 36
GABA 36
glutamate 34
noradrenaline 25
ATP 25
NMDA 22
oxygen 22
potassium 18
nitric oxide 17
acetone 17
DNA 16
5-HT 12
water 9
gamma-aminobutyric acid 7
Morphine 7
arginine 7
Neuronal 6
Neurotol 6
Lidocaine 6
glucose 6
IBA 5
AMPA 5
PGE2 5
IBA 5
Capsaicin 5
Gly 5
Vincristine 5
Sodium 5
GSH 5
GSH 5
phosphate 4
Paclitaxel 4
Lamotrigine 4
ADP 4
tryptophan 4
Tramadol 4
Calcitonin 4
hydrogen 4
T10 4
NAD 4
ACS 3
ADP 3
serine 3
acetic acid 3
ADP 3
Melatonin 3
MTT 3
Mg2+ 3
manganese 3
Malondialdehyde 3
glycerol 3
DMSO 3
Ketamine 3
tyrosine 3
Resveratrol 3
AMP 3
Phe 3
ACS 3
lysine 2
Mexiletine 2
Serine 2
Acetone 2
caffeine 2
Tempol 2
Evans Blue 2
PGE 2
Amiloride 2
cobalt 2
MEK 2
Curcumin 2
leucine 2
Ribose 2
butyric acid 2
Muscimol 2
H2O2 2
CO2 2
APAP 2
zinc 2
Optimal 2
galactose 2
ADP-ribose 2
Substance P 2
1H-imidazole 2
ICI 2
COS 2
T13 2
Panam 2
Methadone 2
STZ 2
aspartic acid 2
NAD 2
DPN 2
sulfate 2
DAMGO 2
Naloxone 2
2-nonenal 2
aldehyde 2
GM1 2
MOP 2
Palmitoylethanolamide 2
glutamine 2
urea 2
Minocycline 2
Botulinum toxin type A 2
1H-imidazole 2
N-acetylcysteine 2
aldehyde 2
Norepinephrine 2
Wellcome 2
4-nitrophenyl 2
Cobalt 1
NIDA 1
Mato 1
TACE 1
Ferulic acid 1
Allergan 1
1,3,4-oxadiazole 1
cAMP 1
Sulforaphane 1
Glutamate 1
Berberine 1
benzamide 1
barium 1
CAP 1
Heroin 1
DMI 1
Ascorbic acid 1
Emodin 1
Metformin 1
chalcone 1
ethanol 1
PAR 1
ASA 1
dipropyl 1
chlorobenzene 1
alanine 1
PPI 1
Metformin 1
Tumor Necrosis Factor 1
Amantadine 1
Diosgenin 1
Bupropion 1
Ketoprofen 1
Vimentin 1
Adenosine 1
vitamin D 1
Piroxicam 1
Oxcarbazepine 1
FK506 1
iron 1
Methylcobalamin 1
formaldehyde 1
Angiotensin II 1
DNP 1
Caryophyllene 1
more...