Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0409974 (lupus)
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Human Gene/Protein
INTERFERON REGULATORY FACTOR 3 10.5
zinc finger protein 688 10.5
solute carrier family 15, member 4 9.9
TROVE domain family, member 2 9.5
Kelch-like protein 7 9.5
Sm D2 9.5
Gamma-aminobutyric acid receptor subunit pi 9.5
FcGR 9.5
SAPL 9.2
PTP-HSCF 8.9
golgin-67 8.9
beta4Gal-T4 8.9
STRBP 8.9
UNC93B1 protein 8.9
Syntaxin-1B 8.9
OCTD 8.9
beta2-glycoprotein I 8.9
EEA1 protein 8.7
TNFSF7 8.5
DIE2 8.5
Kelch-like protein 12 8.5
SCARF1 8.5
splicing factor arginine/serine-rich 3 8.5
DNASE1L1 8.5
archain 8.5
IAN5 8.5
CD52 protein 8.5
HSPA8 protein 8.5
B-cell scaffold protein with ankyrin repeats 8.5
SS-A 8.3
UBE2E1 8.3
IFIX 8.2
SSA 8.2
U1-70K 8.2
Coronin-1B 8.2
LBA1 8.2
vWF-CP 8.2
RC3H1 8.1
TREX1 8.0
ribonuclease H2 8.0
TROVE2 8.0
SS-B 8.0
DEF6 8.0
Ro52 7.9
Interleukin 23 receptor 7.9
KIAA1542 7.9
GALNT18 7.9
phosphodiesterase 8A 7.9
MAR6 7.9
Sm D3 7.9
SSB 7.9
protein-arginine deiminase 7.8
P140 7.7
PROZ 7.7
FYVE-DSP1 7.7
GTAP 7.7
PXK 7.7
Po66-CBP 7.7
tripartite motif-containing 27 7.7
Ro60 7.6
kappa light chain variable region 7.6
p202 7.5
TDFA 7.5
MPS7 7.5
LY6E 7.5
pre-B-cell leukemia homeobox 1 7.5
Scotin 7.5
OLFML3 7.5
TREML4 7.5
CHST12 7.5
sodium phosphate transporter 7.5
NTB-A 7.4
MNDA 7.4
SLC15A4 7.4
Coronin-1A 7.4
protein arginine deiminase 7.4
Roquin 7.3
coronin 7 7.3
TOMM22 7.3
AGS1 7.2
more...
Disease
Chronic proliferative glomerulonephritis 10.5
AIDS with thrombocytopenia 10.5
Limited Wegener's granulomatosis 10.5
syndrome; cervical 10.5
Autoimmune skin disease 10.5
LP-LE overlap 10.5
Purpura rheumatica 10.5
Lupus erythematosus tumidus 10.5
Acute cutaneous lupus erythematosus 10.5
Acute subendocardial infarction 10.5
Malignancy-associated glomerulonephritis 10.5
Idiopathic photodermatosis 10.5
lupus 10.5
thrombosis; pregnancy 10.5
Acquired hypoprothrombinemia 10.5
Chorea Syndrome 10.5
Lupus 10.5
lupus 10.4
Lupus erythematosus profundus 10.4
Rowell's syndrome 10.1
Lupus hepatitis 10.1
Lupus pneumonitis 10.1
Secondary antiphospholipid syndrome 10.1
Lupus myocarditis 10.1
Lupus-like syndrome 10.0
Subacute cutaneous lupus erythematosus 9.9
Neonatal lupus erythematosus 9.8
Cutaneous lupus erythematosus 9.8
drug induced lupus 9.7
SLE arthritis 9.7
SLE flare 9.5
Jadassohn-Pellizzari 9.5
Bacillus infection 9.5
Cerebral lupus 9.5
Purpura hemorrhagica 9.5
Purpura hemorrhagica 9.5
lupus vulgaris tuberculosis 9.5
Oral papillomatosis 9.5
infected insect bite 9.5
Facial psoriasis 9.5
Hughes syndrome 9.4
Senear-Usher syndrome 9.4
systemic lupus erythematosus 9.4
Interface dermatitis 9.2
Acne agminata 9.1
Reticular erythematous mucinosis 9.1
scrofuloderma 9.0
lupus nephritis 9.0
antiphospholipid syndrome 8.9
Isolated myocarditis 8.9
Annular erythema 8.9
pleurisy with effusion 8.9
OCTD 8.9
Rectal necrosis 8.9
Hematocytopenia 8.9
Ovarian hemorrhage 8.9
esthiomene 8.9
Allergic contact cheilitis 8.9
Calcinosis universalis 8.9
Acute on chronic renal failure 8.9
Biett 8.9
Nummular eczema 8.9
Renal thrombosis 8.9
Congenital heart block 8.8
Primary antiphospholipid syndrome 8.8
Cutaneous tuberculosis 8.8
Livedoid vasculitis 8.8
Neuropsychiatric lupus 8.7
Acute toxic hepatitis 8.7
Jessner's lymphocytic infiltration 8.7
Lupus erythematodes 8.6
circulating anticoagulants 8.6
Nasal tuberculosis 8.6
Lupus miliaris disseminatus faciei 8.5
Factor II mutation 8.5
Mitral and aortic regurgitation 8.5
Lupoid leishmaniasis 8.5
Vascular myelopathies 8.5
Axillary vein thrombosis 8.5
Early onset periodontitis 8.5
more...
Symptom
Ballismus 9.5
Red face 9.5
Scaly scalp 8.9
hidroa 8.5
SLE-like symptoms 8.3
livedo 7.9
Juvenile spring eruption 7.7
Subungual hyperkeratosis 7.7
Erythema annulare centrifugum 7.3
decreased bowel sounds 7.0
Livedoid 6.8
Flare 6.8
Cognitive Symptoms 6.7
Urticarial vasculitis 6.6
Diaphragmatic weakness 6.2
waxy flexibility 6.2
Cutaneous anergy 6.2
Murphy's sign 6.1
toe pain 6.0
skin impairment 6.0
gumma 6.0
change in skin color 5.8
chorea 5.7
periorbital edema 5.5
Fetal bradycardia 5.5
Skin symptoms 5.4
arthralgia 5.3
polymyalgia 5.2
Koplik spots 5.2
vestibulitis 5.0
pleuritic chest pain 5.0
Amaurosis fugax 4.8
Musculoskeletal symptoms 4.8
erythema 4.7
pedal edema 4.7
Cushingoid 4.7
Cushingoid 4.7
Visual disturbances 4.7
Neurologic symptoms 4.5
splenomegaly 4.3
Psychiatric symptoms 4.1
catatonia 4.1
scaly skin 4.0
stuffy nose 4.0
onychomadesis 4.0
Vulvodynia 4.0
arm weakness 4.0
feeling depressed 4.0
myalgia 3.9
acute abdominal pain 3.9
trigeminy 3.9
Gastrointestinal symptoms 3.9
cardiovascular impairment 3.7
monoplegia 3.7
orthopnea 3.6
fever of unknown origin 3.5
swollen joints 3.4
leg edema 3.4
asthenia 3.4
dark urine 3.3
lassitude 3.3
leg cramps 3.3
blurred vision 3.3
dry eye 3.2
consciousness disturbance 3.1
shortness of breath 3.1
skin damage 3.1
hepatosplenomegaly 3.1
lightheadedness 3.1
testicular pain 3.0
blushing 3.0
acute abdomen 3.0
ataxic gait 3.0
prostration 2.9
loss of taste 2.9
tonic-clonic seizure 2.9
adenitis 2.9
generalized pain 2.9
hemoptysis 2.8
giddiness 2.8
more...
Drug
Edratide 10.5
Methylprednisolone suleptanate 9.5
Anadrol-50 9.5
Belimumab 8.6
Epratuzumab 7.8
Lobenzarit disodium 7.5
Frentizole 7.5
Abetimus sodium 7.5
BLyS 7.4
Mexoryl SX 7.2
Emivirine 7.2
Plaquenil 7.1
Cellcept 7.1
Cellcept 7.1
Plaquenil 7.0
Uvinul 7.0
Kaolin 7.0
BZQ 6.7
Roquinimex 6.6
Agalsidase alfa 6.5
Pronestyl 6.4
Octocrylene 6.3
Parsol 6.2
Pimecrolimus 6.2
Foscavir 6.0
Cadralazine 6.0
Dyazide 6.0
Bindarit 6.0
Abatacept 5.9
Eusolex 5.8
Ticlopidine hydrochloride 5.8
Calciparine 5.8
Eusolex 5.7
Satraplatin 5.7
Cod liver oil 5.5
Mestinon 5.5
Interferon beta-1a 5.4
Palonosetron hydrochloride 5.4
Sulphasalazine 5.2
Rituximab 5.2
Golimumab 5.2
Interferon alfa-2a 5.1
Infliximab 5.0
Infliximab 5.0
Aredia 4.9
Mycophenolic acid 4.9
Imuran 4.8
Ancrod 4.8
Quinine, 4.8
Prednisone 4.8
Hirulog 4.7
Methylprednisolone 4.6
Certolizumab pegol 4.6
Adalimumab 4.6
Atabrine 4.6
Prednisolone 4.6
Batroxobin 4.5
Gamma globulin 4.4
Marimastat 4.3
Isoniazid 4.3
Pyridostigmine bromide 4.2
CFX 4.2
Dilantin 4.2
Subutex 4.2
Beta-2 4.1
Lepirudin 4.1
Tocilizumab 4.1
Synthroid 4.0
Domin 4.0
Prograf 4.0
Imiquimod 4.0
Valdecoxib 4.0
Nabumetone 3.9
Mizoribine 3.9
Novantrone 3.8
LMWH 3.7
Romidepsin 3.6
Argatroban 3.6
Belatacept 3.6
Estrogens 3.6
more...
Enzyme
GP-I 8.1
dihydrolipoyl transacylase 6.2
thromboplastin 5.9
nicotinic acid mononucleotide adenylyltransferase 5.7
APC 5.1
PHOSPHO1 5.0
ancrod 5.0
carboxypeptidase D 4.5
D-dopachrome tautomerase 4.5
C1 esterase 4.4
methylenetetrahydrofolate reductase 4.4
methylenetetrahydrofolate reductase 4.4
peptidylarginine deiminase 4.3
factor D 4.3
pyruvate dehydrogenase phosphatase 4.0
arylamine N-acetyltransferase 3.7
ceramide kinase 3.7
bromelin 3.7
C3 convertase 3.6
GTI 3.6
versatile peroxidase 3.6
PHT 3.5
formyltetrahydrofolate synthetase 3.3
methylenetetrahydrofolate dehydrogenase 3.2
CDR 3.2
uroporphyrinogen decarboxylase 3.2
prolidase 3.1
inositol phosphatase 3.1
TSP-1 3.1
paraoxonase 3.1
proteinase-3 3.1
Thy1 3.0
p100 3.0
caspase-10 3.0
p80 3.0
caspase-10 2.9
histidyl-tRNA synthetase 2.9
phosphatidylserine synthase 2.9
MCS 2.9
NQO2 2.9
mannosidase II 2.9
thyroid peroxidase 2.9
thrombin 2.8
poly(ADP-ribose) glycohydrolase 2.8
DNase 2.7
DNase II 2.7
phosphatidylethanolamine N-methyltransferase 2.7
tissue plasminogen activator 2.6
paraoxonase 2.6
E-2 2.6
eEF2 kinase 2.6
DNA methyltransferase 2.6
PPH 2.5
CEP 2.5
thrombin-activatable fibrinolysis inhibitor 2.5
bromelain 2.5
C3b inactivator 2.5
arginine deiminase 2.3
LuxS 2.3
granzyme B 2.2
calcineurin 2.2
C3 convertase 2.2
GMT 2.1
caspase-11 2.0
GCA 2.0
caspase-11 2.0
indoleamine 2,3-dioxygenase 2.0
cathepsin G 2.0
deoxyribonuclease 2.0
PME 2.0
CEP 1.9
caspase-1 1.9
TdT 1.9
deoxyribonuclease 1.9
N-acetyltransferase 1.9
carboxypeptidase E 1.8
GLO 1.8
tissue kallikrein 1.8
cyclohydrolase 1.7
CPN 1.7
more...
Compound
Iminostilbene 8.5
Motretinide 8.5
Pristane 8.4
Hydroxychloroquine 8.0
2-azaspiro[4.5]decane 7.9
Aldophosphamide 7.9
Parsol MCX 7.5
T 41 7.3
Hydroxychloroquine sulfate 7.3
Procainamide 7.0
Mycophenolate mofetil 6.8
Tylophorine 6.6
DNPP 6.4
Hydralazine 6.3
ANA 6.2
ANA 6.2
Interferon alfa-2a 6.1
Prospidin 6.0
APS 6.0
DFH 6.0
Tocainide 5.9
Nandrolone decanoate 5.8
Hoechst dye 33258 5.7
Acebutolol 5.7
Aminoimidazole 5.7
ANCA 5.6
AFMU 5.5
S 9 5.4
Minocycline hydrochloride 5.3
11-dehydro-thromboxane 5.2
Salvarsan 5.2
Eusolex 5.2
Nickel chloride 5.0
Leflunomide 4.9
Mephenytoin 4.9
Nafoxidine 4.9
PAPS 4.8
Azathioprine 4.8
Tanakan 4.8
Practolol 4.8
Methylprednisolone 4.8
Fluocinolone acetonide 4.7
DQ1 4.7
Etanercept 4.7
Prednisolone 4.6
Tuftsin 4.6
MMD 4.6
Desogestrel 4.6
Danazol 4.5
4-Methylumbelliferone 4.5
PYC 4.5
8-hydroxyguanosine 4.4
Minocycline 4.4
Clofazimine 4.4
NHD 4.3
16 alpha-hydroxyestrone 4.3
TMPD 4.3
Quinacrine 4.3
1,2,4,5-tetrachlorobenzene 4.3
X 13 4.3
Distamycin A 4.2
Quinacrine 4.2
Terbinafine 4.2
Prednisone 4.1
TNX 4.1
13-cis-Retinoic acid 4.0
Warfarin 4.0
CCP 4.0
Deoxyspergualin 4.0
Anastrozole 3.8
Paeoniflorin 3.8
Coumestrol 3.8
phthalazine 3.8
S-phenyl 3.8
Chloroquine 3.8
Chloroquine 3.8
Potassium permanganate 3.8
S-phenyl 3.8
F23 3.7
FDP 3.7
more...