Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1297
cytokine 658
She 574
prothrombin 546
glycoprotein 527
thromboplastin 514
CD4 478
SSA 368
IFN 354
Mol 353
interferon 345
IgA 313
lymphoid 300
protein C 296
IL-6 279
beta2-glycoprotein I 274
collagen 264
TNF 258
protein S 255
histone 248
Fas 242
SSB 233
CD8 229
ANA 225
IL-10 216
autoantigen 214
RNP 211
HLA 201
ACR 198
rheumatoid factor 177
SS-A 176
thrombin 174
dilute 166
tumor necrosis factor 151
thymus 149
IFN-gamma 144
C-reactive protein 142
TLR7 141
factor V Leiden 140
IL-4 137
IL-2 132
TNF-alpha 130
factor VIII 130
BAFF 124
MHC 123
TLR9 122
GPI 120
MRI 119
fibrinogen 117
SS-B 116
antithrombin 115
antithrombin III 114
lipopolysaccharide 113
IL-17 113
insulin 108
TCR 103
factor V 100
IgG3 98
type I interferon 96
albumin 95
APS 94
CD20 87
ribonucleoprotein 85
major histocompatibility complex 84
CD25 84
LPS 82
serum albumin 81
prolactin 81
chemokine 81
CD40 79
mucin 78
CD40L 70
ankylosing spondylitis 70
MHC class II 69
hemoglobin 69
von Willebrand factor 69
Pol 69
CD28 68
annexin V 67
Ro52 66
myeloperoxidase 66
B lymphocyte stimulator 66
CD45 65
T cell receptor 64
ESR 64
gut 63
interleukin-6 62
3 beta-HSD 62
APC 60
interferon-gamma 60
heavy chain 60
plasminogen 58
IL-1 57
tissue factor 56
H2B 56
BCR 56
HLA-DR 54
U1-70K 52
VIII 52
TLR4 52
Mal 51
DBA 51
calcineurin 51
chronic renal failure 51
factor Xa 50
CD86 50
ICAM-1 49
H2A 49
CRP 49
CD19 49
polypeptide 49
class V 48
IgE 47
TGF-beta 46
Prothrombin 44
DR3 43
kit 43
ARA 43
PLA 42
plasminogen activator inhibitor 42
IL-18 41
IL-8 41
ATP 41
Cytokine 41
Y chromosome 40
HLA-DR3 40
ENA 40
thrombomodulin 40
non-Hodgkin's lymphoma 39
IL-21 39
Ro60 39
Bcl-2 39
MAPK 38
CD40 ligand 38
CD80 37
peroxidase 36
SLAM 36
plasminogen activator inhibitor-1 36
interleukin-2 36
interferon-alpha 36
vascular cell adhesion molecule-1 36
CSF 35
cryptic 35
X-linked 35
ERK 34
CD95 34
Fas ligand 34
IL-23 33
adhesion molecule 33
P protein 33
factor XII 33
CXCL10 33
B10 32
lectin 32
phosphatase 32
CD11b 32
mTOR 32
Protein C 32
HDL 32
membrane-bound 31
more...
Disease
lupus 22386
systemic lupus erythematosus 20554
lupus 14988
Lupus 6888
autoimmune disease 1963
antiphospholipid syndrome 1672
lupus nephritis 1638
rheumatoid arthritis 1256
SLE 1248
glomerulonephritis 999
vasculitis 903
arthritis 872
renal disease 869
proteinuria 846
thrombocytopenia 811
nephritis 726
cancer 601
hypertension 535
rash 474
diabetes 387
atherosclerosis 338
scleroderma 329
psoriasis 324
dermatomyositis 318
PSS 313
multiple sclerosis 308
tuberculosis 300
stroke 296
renal failure 273
abortion 262
photosensitivity 257
nephrotic syndrome 253
connective tissue disease 250
heart block 247
skin disease 243
anemia 237
tumor 230
lymphadenopathy 226
preeclampsia 218
dermatitis 213
lymphoma 205
deep vein thrombosis 202
lichen planus 197
pneumonia 192
depression 191
hemolytic anemia 184
HIV 178
panniculitis 175
hepatitis 162
sarcoidosis 159
pulmonary hypertension 158
systemic disease 157
mixed connective tissue disease 157
cardiovascular disease 153
plaque 150
infectious diseases 150
immunodeficiency 150
syphilis 138
Raynaud's phenomenon 137
myocardial infarction 137
Crohn's disease 135
leukopenia 133
psychosis 132
sepsis 131
membranous nephropathy 130
polymyositis 128
graft-versus-host disease 128
pericarditis 125
pemphigus 125
pulmonary embolism 122
sepsis 119
virus infection 117
vascular disease 117
myocarditis 116
thrombocytopenic purpura 111
Infection 108
Sjogren's syndrome 108
purpura 108
polyarthritis 107
atopic dermatitis 107
ischemia 107
pemphigoid 102
urticaria 99
glomerulosclerosis 97
PGA 97
osteoporosis 97
erythema multiforme 96
cognitive impairment 94
Neonatal lupus erythematosus 93
chronic renal failure 92
rheumatism 92
myositis 91
heart failure 90
lymphopenia 88
Epstein 88
AIDS 87
asthma 86
carcinoma 86
inflammatory bowel disease 84
hypergammaglobulinemia 84
myasthenia gravis 83
migraine 81
IgA nephropathy 81
pancytopenia 81
type 1 diabetes 80
renal insufficiency 79
myelitis 78
coronary artery disease 78
Mycobacterium 78
multiple myeloma 76
idiopathic thrombocytopenic purpura 76
neuropathy 76
Raynaud 75
leukemia 75
cold 75
autoimmune hemolytic anemia 74
Best 73
leprosy 73
coagulopathy 73
ankylosing spondylitis 73
Wegener's granulomatosis 72
epilepsy 72
peritonitis 72
pericardial effusion 71
ulcerative colitis 71
confusion 70
cytomegalovirus 70
hepatitis B 69
lichen 69
liver disease 69
neutropenia 68
obesity 67
acne 67
chronic disease 67
vitiligo 65
rare disease 65
parvovirus 65
psoriatic arthritis 64
polyarteritis nodosa 63
Syndrome 63
disseminated intravascular coagulation 62
immunopathology 62
interstitial lung disease 61
squamous cell carcinoma 61
erythema nodosum 60
hepatitis C 60
APC 60
cardiomyopathy 59
breast cancer 59
Cutaneous lupus erythematosus 59
encephalomyelitis 59
encephalopathy 59
Graves' disease 58
endocarditis 58
acute renal failure 57
Hodgkin's disease 57
mimicry 57
arthropathy 57
peripheral neuropathy 56
glomerulopathy 56
more...
Symptom
erythema 248
seizures 215
pain 213
arthralgia 200
headache 185
fatigue 163
abdominal pain 151
livedo 148
splenomegaly 140
dyspnea 103
weakness 94
diarrhea 91
vomiting 84
chorea 79
myalgia 71
nausea 70
chest pain 51
Ill 45
cough 40
shortness of breath 31
hemoptysis 31
angina 30
respiratory distress 29
collapse 28
hepatosplenomegaly 26
acute abdominal pain 21
anesthesia 21
anorexia 19
hepatomegaly 19
asthenia 19
numbness 17
acute abdomen 17
dry eye 17
regurgitation 17
fever of unknown origin 17
dizziness 16
chills 15
vertigo 15
Flare 14
blurred vision 14
discomfort 14
exertional dyspnea 14
ataxia 14
insomnia 14
dysarthria 13
lethargy 13
sleepiness 13
pleuritic chest pain 13
catatonia 13
cerebellar ataxia 12
discomfort 12
nausea and vomiting 12
overweight 12
back pain 11
dysuria 11
epigastric pain 11
paresthesia 11
memory loss 11
hemiplegia 11
syncope 10
paresis 10
thinning 9
skin damage 9
flushing 9
paraparesis 9
cachexia 9
periorbital edema 8
agitation 8
spasm 7
exhaustion 7
dystonia 7
tonic-clonic seizure 7
oliguria 7
tense 7
pallor 7
tachypnea 6
hip pain 6
hoarseness 6
tinnitus 6
Gastrointestinal symptoms 6
cyanosis 5
tremor 5
hypothermia 5
functional recovery 5
low back pain 5
consciousness disturbance 5
ophthalmoplegia 5
analgesia 5
leg edema 5
polyuria 5
bradykinesia 5
tingling 5
sore throat 5
gumma 4
starvation 4
hypoproteinemia 4
Psychiatric symptoms 4
Cushingoid 4
polydipsia 4
orthopnea 4
pedal edema 4
Livedoid 4
spasticity 4
myoclonus 4
swollen joints 4
productive cough 4
night sweats 4
abdominal discomfort 4
Cushingoid 4
heartburn 4
Neurologic symptoms 3
Erythema annulare centrifugum 3
Urticarial vasculitis 3
adenitis 3
leg pain 3
muscle stiffness 3
lightheadedness 3
polymyalgia 3
constipation 3
forgetfulness 3
Depressive symptoms 3
ataxic gait 3
sciatica 3
vestibulitis 3
urinary frequency 3
Murphy's sign 3
photophobia 3
Skin symptoms 2
groin pain 2
abnormal gait 2
alexithymia 2
loss of taste 2
testicular pain 2
arm weakness 2
hunger 2
hyperemesis gravidarum 2
partial seizure 2
Fluctuation 2
syncopal episodes 2
distraction 2
rigors 2
dark urine 2
renal colic 2
scaly skin 2
Musculoskeletal symptoms 2
exertional angina 2
SLE-like symptoms 2
physical appearance 2
knee pain 2
pelvic pain 2
prostration 2
Visual disturbances 2
lassitude 2
Decreased activity 2
apathy 2
ENT 2
stridor 1
hidroa 1
Subungual hyperkeratosis 1
skin impairment 1
more...
Drug
Dermatol 1260
IFN-gamma 141
IL-2 132
Rituximab 73
CSF 61
CTX 49
Nephron 43
Cardiovasc 34
Dial 33
Belimumab 27
Infliximab 26
Infliximab 26
Prednisolone 25
Nephron 25
lysine 24
BLyS 24
Kaolin 21
Prednisone 20
Estrogens 19
Methylprednisolone 16
ROC 16
Tacrolimus 14
Isoniazid 13
Gel 13
ROS 12
G-CSF 12
p75 11
DNase I 11
MAP 10
EE2 10
Silica 9
Adalimumab 9
ENT 9
Alliance 8
Vitamin B12 8
Bortezomib 8
Abatacept 8
Asthma 8
ampicillin 8
vitamin E 7
Monit 7
Retinoic acid 7
IFN-beta 7
Mycophenolic acid 7
Epratuzumab 6
ABC 6
BLM 6
THF 6
Imiquimod 6
Dakar 6
Leaf 6
Fluorescein 6
Pimecrolimus 6
Fluorescein 6
Bifidobacterium 6
Vitamin K 6
Asn 5
ascorbate 5
Captopril 5
CAM 5
niacin 5
LMWH 5
Tocilizumab 5
CTX 5
caffeine 5
CTX 5
Plaquenil 4
Sulphasalazine 4
nitroglycerin 4
Plaquenil 4
TAT 4
Orphan 4
PCB 4
Lovastatin 4
NAG 4
PFA 3
BCG vaccine 3
CaCl2 3
Antithrombin III 3
EPI 3
CaCl2 3
CaCl2 3
Acyclovir 3
Zoledronic acid 3
Dalteparin 3
Isotretinoin 3
ICI 3
Phenytoin 3
Cellcept 3
Cellcept 3
uPA 3
Indomethacin 3
Glutathione 3
PTC 3
Zoledronic acid 3
Bayer 3
MDS 3
Angiotensin II 2
Parsol 2
Hypaque 2
Albumin 2
Biopolymers 2
CDP 2
NH3 2
Campath 2
TiO2 2
Serum albumin 2
Anakinra 2
Histamine 2
Dilantin 2
Ancrod 2
Novantrone 2
ETS 2
Coumadin 2
Bosentan 2
Fraction 2
Imuran 2
IL-1ra 2
Arsenic trioxide 2
Tuberculin 2
Fragment 2
Teriparatide 2
Bevacizumab 2
Bosentan 2
Argatroban 2
Edratide 2
Nitric Oxide 2
HCG 2
Simvastatin 2
AGG 2
Eculizumab 2
Quinine, 2
Gastro 2
CFX 2
Phosphatidylserine 2
CIA 2
CVA 2
Cellulose acetate 2
Prograf 2
Campath 2
Golimumab 2
Urokinase 2
Beta-2 2
HCH 2
Fondaparinux 2
EPA 2
NADH 1
Batroxobin 1
Subutex 1
TAK 1
CPM 1
Activin 1
Gleevec 1
Uvinul 1
Spectrum 1
Dyazide 1
Fludarabine 1
Trifluoperazine 1
Aredia 1
Octocrylene 1
more...
Enzyme
thromboplastin 544
APC 406
thrombin 168
peroxidase 99
mitogen-activated protein kinase 79
ERK 64
calcineurin 57
focal adhesion kinase 56
tissue plasminogen activator 49
DNase 36
methylenetetrahydrofolate reductase 31
methylenetetrahydrofolate reductase 31
catalase 30
alkaline phosphatase 27
RNase 27
protein kinase 26
superoxide dismutase 26
proteasome 25
RNA polymerase 25
RNase 24
creatine kinase 24
ACE 22
trypsin 21
DNA methyltransferase 21
alanine aminotransferase 21
protein kinase C 20
reverse transcriptase 18
caspase-3 18
caspase-1 17
renin 17
aspartate aminotransferase 17
CDR 16
NADPH oxidase 16
NADPH oxidase 16
thyroid peroxidase 16
urokinase-type plasminogen activator 15
luciferase 14
lysozyme 14
lactate dehydrogenase 14
glutathione peroxidase 14
plasmin 13
ATPase 13
neuraminidase 12
granzyme B 11
elastase 11
GP-I 11
kallikrein 10
paraoxonase 10
collagenase 10
endonuclease 10
MEK 10
ACS 10
C3 convertase 9
paraoxonase 9
transglutaminase 8
AST 8
DNA polymerase 8
phosphodiesterase 7
lipase 7
ornithine decarboxylase 7
transcriptase 7
Thy1 7
MMP 6
MIP 6
N-acetyltransferase 6
GSK 6
beta-galactosidase 6
phospholipase A2 6
glutathione S-transferase 6
factor D 6
MAP 6
glyceraldehyde-3-phosphate dehydrogenase 6
NO synthase 6
gamma-glutamyl transpeptidase 5
ceruloplasmin 5
TSP-1 5
enolase 5
cathepsin G 5
PAH 5
pepsin 5
p100 5
IKK 5
AMPK 5
STR 5
peptidylarginine deiminase 5
CAD 5
ribonuclease 5
acetylcholinesterase 5
AMPK 5
tryptase 5
TdT 5
AMP-activated protein kinase 5
PARP 5
ribonuclease 5
CAD 5
CAD 5
ancrod 5
glutathione reductase 4
prostaglandin synthetase 4
S1 nuclease 4
TAT 4
BMT 4
BAL 4
indoleamine 2,3-dioxygenase 4
caspase-8 4
heme oxygenase 4
deoxyribonuclease 4
ATP synthase 4
phosphatidylinositol 3-kinase 4
lipoxygenase 4
bromelain 4
phosphoinositide 3-kinase 4
MCS 4
deoxyribonuclease 4
p80 3
CD10 3
acid phosphatase 3
pyruvate dehydrogenase 3
CEP 3
arginine deiminase 3
pyruvate dehydrogenase 3
tissue kallikrein 3
neutrophil elastase 3
E-2 3
prolidase 3
cholinesterase 3
C3 convertase 3
cdc2 3
pyruvate dehydrogenase 3
hexokinase 3
sialidase 3
uroporphyrinogen decarboxylase 3
CEP 3
glyceraldehyde-3-phosphate dehydrogenase 3
MMP-3 2
proteinase-3 2
Alternating 2
hexosaminidase 2
histone demethylase 2
inositol phosphatase 2
topoisomerase 2
tyrosine hydroxylase 2
phospholipase C 2
P-glycoprotein 2
DAT 2
topoisomerase 2
adenosine deaminase 2
histone acetyltransferase 2
arylamine N-acetyltransferase 2
purine nucleoside phosphorylase 2
DNase II 2
CYP3A4 2
demethylase 2
dihydrofolate reductase 2
caspase-9 2
sialyltransferase 2
sialyltransferase 2
NOS 2
mannosidase II 2
sialyltransferase 2
more...
Compound
DNA 2315
Clin 2254
Dec 1425
creatinine 322
TNF 258
ANA 226
ANA 226
calcium 176
oxygen 131
APS 94
arginine 94
water 91
His 88
Hydroxychloroquine 86
phosphate 81
Cardiol 78
tyrosine 70
glucose 70
vitamin D 68
acetate 68
urea 65
homocysteine 65
ANCA 62
nitrogen 60
sulfate 57
BCR 56
sodium 55
nitric oxide 52
DBA 51
DBA 51
DBA 51
serine 50
CTX 49
prostacyclin 48
Mycophenolate mofetil 45
Estrogen 45
ATP 41
Estrogen 37
salt 35
Pristane 34
Hydralazine 33
leucine 33
Dial 33
iron 33
mercury 31
lysine 31
Neo 29
hydrogen 29
Warfarin 29
Heparin 28
potassium 27
zinc 27
SDS 27
INH 26
Asp 26
Prednisolone 25
Procainamide 25
ADP 24
hydroxylamine 24
hydroxylamine 24
tryptophan 23
ASA 22
PEG 22
NKT 21
tryptophan 21
tryptophan 21
tryptophan 21
threonine 21
Azathioprine 20
Prednisone 20
methionine 20
Optimal 20
Cyclosporine 20
FK506 19
Chloroquine 18
alanine 18
ADP 18
Chloroquine 18
ADP 18
iodine 18
CCP 18
Thrombin 17
CO2 17
retinoic acid 16
ethanol 16
copper 16
galactose 16
PMA 16
A 42 16
glutamate 16
ammonium 16
DSS 16
Methylprednisolone 16
6-12 15
H2O2 15
BCG 15
PMA 15
Thyroid 15
Pac 15
Minocycline 14
Phe 14
neopterin 14
silicon 13
GSH 13
Collagen 13
nicotinamide 13
GSH 13
Gly 13
ITP 13
cysteine 13
Methotrexate 13
DEAE 13
NH2 13
silver 12
ADP-ribose 12
DNP 12
DHA 12
AMP 12
glycerol 12
glutamine 12
Fibrinogen 12
EDTA 12
THP 11
cadmium 11
THP 11
bromide 11
hyaluronic acid 11
ACTH 11
Vitamin D 11
TSH 11
Etanercept 11
prostaglandin E1 11
EDTA 11
asparagine 10
ACS 10
Histone 10
pyrimidine 10
cAMP 10
pyrimidine 10
ACS 10
PAPS 10
proline 10
selenium 10
PGE 10
aldehyde 9
Danazol 9
Ile 9
FDP 9
PAS 9
Insulin 9
cGMP 9
Isoproterenol 9
quinoline 9
quinoline 9
Retinal 9
nitrate 9
valine 9
TOF 9
DPA 8
Mato 8
more...