Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this work was to characterise the eye muscle antigens reacting with autoantibodies from Graves ophthalmopathy patients to elucidate the function of these antibodies. As estimated by ELISA test antibodies of IgG class reacting with porcine microsomal membranes are present in about 25% of patients while of IgM class in about 15% of patients with Graves ophthalmopathy. Their presence do not correlate with ophthalmopathy index, neither they have relation to treatment. Anti eye muscle antibodies were present at some stages of the disease in three patients who develop ophthalmopathy, from the group of 26 patients treated during one year for hyperthyroidism. However, sporadically these antibodies were found also in about 20% of patients with Hashimoto disease, Lupus erythematosus or Scleroderma. Some of them cross react with antigens of skeletal muscle and liver. Eye muscle antigens reacting with patients antibodies are localised in plasma membranes and in membranes of smooth reticulum. Affinity purification of solubilised porcine eye muscle membrane proteins on a column with immunoglobulins from pooled serum of patients resulted in 23 fold purification of the antigen. The sensitivity of ELISA was not significantly increased by the use of affinity purified antigen, however some of previously negative ophthalmopathy sera gave positive reaction. Porcine eye muscle membrane proteins were separated by SDS PAGE and transferred to nitrocellulose. The reactions of electroblotted proteins with sera from patients with Graves ophthalmopathy and also sera from healthy controls shown very complex pattern. There was not a single antigen or antigens reacting only with antibodies present in sera of ophthalmopathy patients and not in controls. Patients sera reacted more often than control sera with an antigen of about 40 kDa. The reaction of sera from some patients with proteins about 100, 70 and 65 kDa were stronger than between these proteins and control sera. No changes in the pattern of reaction between antibodies and eye muscle antigens were noticed in serum of the same Graves' patient with or without ophthalmopathy during one year follow up and treatment, regardless of clinical course of the disease. When human eye muscle membrane fractions from tissue obtained during strabismus repair or at autopsy was used for immunoblotting, smaller number of proteins reacted with autoantibodies. Again there was no single antigen or antigens reacting with antibodies from sera of all Graves ophthalmopathy patients. Sera of some patients reacted with antigens about 50 kDa, not recognized by controls. The results of present study show, that the anti eye muscle antibodies are present in some of Graves ophthalmopathy patients.(ABSTRACT TRUNCATED AT 400 WORDS)
Endokrynol Pol 1992
PMID:[Muscle antigens recognized with autoantibodies in patients with Graves' ophthalmopathy]. 134 58

Antiphospholipid antibodies (lupus anticoagulant and anticardiolipin antibodies), circulating polyclonal immunoglobulins have recently been strongly linked to immune mediated thromboembolic events. In the present paper the role of antiphospholipid antibodies in the pathogenesis of cerebrovascular disease is discussed.
Neurol Neurochir Pol
PMID:[Anti-phospholipid antibodies--their role in neurological diseases]. 152 81

The diagnosis of systemic lupus erythematosus in cases with advanced renal failure is a serious clinical problem. The purpose of the study was an analysis of the incidence of various non-renal criteria (according to ARA) for the diagnosis of SLE in patients with chronic renal failure of various aetiology and find out whether the lupus band test in these patients may serve as an additional criterion for the diagnosis of SLE. The studied group comprised 39 patients with chronic renal failure (28 men and 13 women) aged 17-58 years. In this group 29 cases were treated with dialyses and 10 conservatively. The most frequent clinical sign (apart from renal changes) accepted as diagnostic criteria for the SLE was polyserositis and leucopenia and thrombocytopenia. In no case antinuclear antibodies, antibodies against DNA and against soluble nuclear antigens were found. Positive LBT was obtained in 72.4% of cases with chronic renal failure, particularly frequently in the dialysed patients. A positive result of the LBT cannot be of decisive importance in the diagnosis of SLE but may suggest a need of more detailed investigations (determination of Ro antibodies) for confirmation of the diagnosis.
Pol Arch Med Wewn 1990 Sep
PMID:[Diagnostic value of the lupus band test in patients treated by chronic hemodialysis]. 226 70

A human IgM monoclonal antibody (Pol-1, SA-1) was generated by the human hybridoma technique from the peripheral blood lymphocytes (PBL) of a patient with active polymyositis. The antibody was found to bind to ssDNA, dsDNA, poly(I) and poly(G) and to carry the common lupus anti-DNA antibody idiotype (16/6 Id). Another human IgM monoclonal antibody (Pol-2, SA-2) produced by similar methods from the PBL of the same patient while in remission lacked the ligand-binding capacities of Pol-1 SA-1 and did not have the 16/6 Id. Analyses of 19 sera samples from patients with polymyositis showed no antinuclear antibodies, excluding a 40% prevalence of the 16/6 Id. The serum of the patient whose lymphocytes were employed to generate the hybridoma was negative for anti-DNA activity as well as for the 16/6 Id. This study suggests that the hybridoma technique may enable expression of dormant idiotypic affinities which do not normally appear in sera.
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PMID:A human monoclonal anti-DNA antibody derived from a patient with polymyositis having the common lupus 16/6 idiotype. 326 49

The reported case was observed in a patient aged 54 years with disseminated lesions in the central nervous system. The history of the disease covered 18 years with periods of exacerbations and remissions. Seven years after the appearance of neurological signs involvement of the internal organs and skin was noted. In the serum antinuclear antibodies, LE cells and high gamma globulin level were demonstrated. The course of the disease and the observed immunological changes justify the diagnosis of the lupoid sclerosis form of visceral lupus erythematosus.
Neurol Neurochir Pol
PMID:[Diagnostic difficulties in a case of visceral lupus with disseminated neurological signs]. 608 20

In a 21-year-old female patient with lupus erythematosus exacerbation of the disease developed during pregnancy leading to eclampsia and birth of a stillborn fetus. After 10 years of immunosupressive treatment the patient continuing treatment with prednisone had another sucessful pregnancy with birth of a healthy child. Serious organ changes observed in the first years of the disease regressed completelt during 12 years of immunosupressive treatment. Throughout the whole observation period antinuclear antibodies were found in the serum, and in the last year their titre of antobodies to native DNA was high. The necessity of many years of immunosupressive treatment of patients with visceral lupus erythematosus is stressed.
Pol Tyg Lek 1980 May 19
PMID:[High titre of antibodies to ds-DNA in a case of visceral lupus erythematosus with remission during many years]. 741 97

We presented the coexistence of the severe aortic insufficiency and the systemic lupus erythematosus with antiphospholipid syndrome in 33-years old woman. She was qualified for the operation of the prosthesis aortic valve replacement after she was treated with steroids. During the operation, the heart infarct of the inferior wall had been observed, but finally in the postoperation period the heart efficiency improvement was observed. We have discussed same theories and clinical experiences of lupus erythematosus with antiphospholipid syndrome and clinical sequels.
Pol Arch Med Wewn 1994 Dec
PMID:[Coexistence of severe aortic insufficiency and systemic lupus erythematosis with antiphospholipid syndrome--case report]. 771 57

Lupus anticoagulant and anticardiolipin antibodies belong to a heterogeneous family of antiphospholipid antibodies, directed probably against complexes composed of protein and negatively charged phospholipids. The antiphospholipid syndrome consists in the association of antiphospholipid antibodies and both venous and arterial occlusive events. The mechanism by which the antiphospholipid antibodies could induce thrombosis remains unclear.
Acta Haematol Pol 1994
PMID:[Diagnostic antiphospholipid antibodies and their clinical significance]. 799 77

The subject of analysis were data concerning the 101 pregnancies in 43 patients with systemic lupus erythematodes observed in years 1965-1990. The evaluation proved that pregnancy does not deteriorate the course of lupus nephritis that is in the remission before the conception. In lupus patients the risk of fetal loss and stillbirth is high, especially in the presence of anticardiolipin antibodies. The course of active lupus occurring during pregnancy is frequently severe and its effect on the pregnancy is very harmful.
Ginekol Pol 1995 Jun
PMID:[Lupus pregnancy, its effect on the course of lupus nephritis and the evaluation of fetal loss frequency]. 852 33

106 women was screened for a lupus anticoagulant. Activated partial thromboplastin time, tissue thromboplastin inhibition test and euglobulin lysis time was performed. Ten of 61 women (16%) with spontaneous multiple abortions, foetal death, intrauterine growth retardation (IUGR) and gestosis had one or two pathological results of tests while no one of the 41 women which had no pregnancy complication. Significance of difference between this two groups was verified by Fischer exact test (P less than 0.05).
Ginekol Pol 1995 Feb
PMID:[Hemostatic disturbances in women with unexplained fetal loss]. 857 82


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