Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fluorescent treponemal antibody absorption tests were performed on serum samples from 43 patients with lupus erythematosus (LE). Seven borderline and three reactive results were obtained from patients who had no evidence of syphilis, and Treponema pallidum immobilization (TPI) tests were nonreactive. These probable nonsyphilitic reactions were associated with discoid LE (DLE) as frequently as with systemic LE (SLE). Three of these serum samples were reactive in the microhemagglutination assay for T pallidum antibodies (MHA-TP), but titers were low. Reactive FTA-ABS tests were also obtained from four patients with LE with evidence of syphilis. All four serum samples were highly reactive in the MHA-TP test. These findings suggest that nonsyphilitic FTA-ABS fluorescence is (1) common with both DLE and SLE, (2) frequently not "beaded" in pattern, and (3) often detectable when MHA-TP tests are performed.
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PMID:Borderline and reactive FTA-ABS. Results in lupus erythematosus. 83 21

Sera of patients with lupus erythematosus can produce false-positive reactions in most serologic tests for syphilis, including the FTA-ABS test. False-positive reactions in the FTA-ABS test can exhibit beaded, borderline or reactive patterns of fluorescence. Beaded fluorescence is commonly associated with anti-DNA antibody and other correlates of lupus activity. Borderline and reactive results are common in both systemic and discoid lupus erythematosus, and are usually not associated with increased clinical activity. TPI and MHA-TP tests appear helpful in detecting false-positive FTA-ABS results.
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PMID:Lupus erythematosus and reactive tests for syphilis: update. 101 53

Sera from 3028 patients attending a dermatological clinic were examined by the fluorescent treponemal antibody (FTA) test, the fluorescent antibody-absorbed (FTA-ABS) test, the Venereal Disease Research Laboratory (VDRL) test, and Kolmer's test. Eleven cases of late syphilis were found. Sera from 63 (2.08%) of the remaining 3017 patients showed non-specific results; these were found more frequently in patients with pyodermas, neoplasms, acne, mycoses, crural ulceration, and psoriasis than in those with other diseases. No non-specific results were observed in patients with bullous skin diseases and only a few in patients with viral skin diseases and chronic lupus erythematosus. The test producing the most non-specific results was the FTA test, followed by the FTA-ABS test, the VDRL test, and Kolmer's test.
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PMID:Non-specific positive test results to syphilis in dermatological diseases. 698 44