Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A woman with hypertension had been treated with hydralazine and propranolol for the past 6 years. Leg ulcers and mild joint involvement had been observed for 3 years. When oral zinc therapy was started, multisystemic manifestations of a lupus erythematosus-like syndrome developed within one week. The possible implication of zinc in drug-induced lupus is discussed.
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PMID:Drug-induced lupus erythematosus aggravated by oral zinc therapy. 9 57

An infant with short stature and progressive skin lesions of cheeks and dorsum of the hands is described. Further problems such as recurrent diarrhoea and respiratory infections suggested zinc-deficiency, malabsorption-syndrome, Bloom syndrome and early Lupus Erythematosus respectively. Finally Rothmund-Thomson syndrome was diagnosed. This rare genetic disorder is characterized by variable expression of typical cutaneous changes, cataracts, skeletal anomalies, short stature, abnormal hair growth and defective nails and teeth, mental retardation, hypogonadism and a typical facial appearance.
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PMID:[An infant with short stature and red cheeks (Rothmund-Thomson syndrome)]. 177 48

Serum SS-A/Ro autoantibodies are commonly found in patients with Sjogren's syndrome, systemic lupus erythematosus, neonatal lupus, and subacute cutaneous lupus. Two proteins of 60 and 52 kD have been described as targets for these autoantibodies. To define the 52-kD component unambiguously, cDNA clones were isolated from human HepG2 and MOLT-4 cell cDNA libraries. The identity of cDNA was established by (a) the specificity of the antibody affinity purified from the recombinant protein, (b) the reactivity of the purified recombinant protein with prototype SS-A/Ro sera in immunoblot and ELISA, and (c) two-dimensional gel comigration of MOLT-4 cell 52-kD protein and the recombinant protein. A 1.9-kb cDNA encoded the complete 52-kD protein containing 475 amino acids (Mr 54,082). Putative zinc-finger domains and a leucine zipper motif were identified in the amino-terminal half of the 52-kD protein, implicating its possible association with DNA/RNA. Sequence homology detected between the 52-kD protein and human ret transforming protein, and mouse T cell gene expression down-regulatory protein rpt-1, may provide leads to the functional role of the 52-kD protein in addition to the possibility that these proteins might constitute members of a subfamily of finger proteins.
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PMID:Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. 198 12

Studies of diet in the mouse model of SLE have established the beneficial effects of a low calorie, low fat diet in these animals as well as the importance of the specific source of dietary fat. The role of zinc in murine and human SLE is less clear. The reported improvement of patients with SLE and other related diseases on a low phenylalanine and tyrosine diet high in fish content, and the lupus inducing capacity of a nonphysiologic amino acid present in alfalfa are also reviewed. The need for carefully controlled prospective studies of diet in patients with SLE is noted, and a diet of potential therapeutic benefit is described.
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PMID:The role of diet in animal models of systemic lupus erythematosus: possible implications for human lupus. 389 77

The role of nutrition in modulating autoantibody expression in murine lupus has become well documented. One such nutritional factor, zinc deficiency, has received significant attention because of the well-known effects of zinc on the immune function of genetically normal animals. Moreover zinc-deficient diets retard autoantibody production in NZB, NZB/W, and MRL/1 mice; such deprivation also enhances survival in all three strains. Because zinc nutriture influences vitamin A metabolism, it has been postulated that the immunologic effects of zinc deficiency are mediated in part by the reduction of vitamin A levels seen in zinc deprivation. To explore this possibility we studied the influence of vitamin A deficiency, in zinc well-nourished mice, on autoantibody production in NZB mice. Groups of NZB mice, beginning at 6 mo of age, were fed a vitamin A-deficient diet or a control diet ad libitum or pair-fed to the deficient group. The diet contained casein as the protein source and contained adequate levels of trace elements and vitamins. Despite our hypothesis that the reduction of autoantibodies in zinc-deficient NZB mice might be mediated by secondary vitamin A deficiency, we found that vitamin A-deficient animals manifested more severe hypergammaglobulinemia and an earlier onset of both NTA and IgM anti-erythrocyte autoantibodies than did vitamin A-sufficient mice. These results illustrate the importance of rigorous studies of select nutritional parameters and warn of the possibility of clinical harm in feeding inappropriate diets to patients with systemic lupus erythematosis.
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PMID:Nutritional factors and autoimmunity. IV. Dietary vitamin A deprivation induces a selective increase in IgM autoantibodies and hypergammaglobulinemia in New Zealand Black mice. 660 78

To investigate further the modulation of autoimmune disease by nutritional means, the influence of zinc deprivation upon the development of the immunopathology of MRL/I mice was studied. Because some effects of zinc deficiency may be due to associated inanition and consequent caloric deprivation, mice with similarly restricted food intake but adequate zinc intake were also studied. Zinc restriction was introduced at either 4 or 10 wk of age and was continued throughout the study. When zinc deficiency was introduced at 4 wk of age, a significant delay in the appearance of the physical findings of MRL/I mice, including open sores, necrotic ears, arthritis, and end-stage cachexia, was noted. In addition, zinc deficiency introduced at this age resulted in a lower incidence and titer of antibodies to dsDNA and less severe glomerulonephritis than control mice. Furthermore, the immune response of zinc-deprived MRL/I mice was better preserved than control animals, and most importantly, survival was significantly prolonged. Pair-fed controls also showed delayed progression of their disease, but animals restricted isocalorically from 4 wk of age experienced a more rapid onset of the lupus-like syndrome than did their zinc-deprived counterparts. In contrast, when zinc deprivation was introduced at 10 wk of age, it had little beneficial effect upon disease progression. Indeed, caloric restriction introduced at this age had a greater impact than did zinc deficiency. Nonetheless, despite the variable influence of zinc deprivation and pair-feeding on autoimmune disease, zinc deprivation, whether introduced at 4 or 10 wk of age, resulted in a significantly greater reduction of lymphoproliferation. Successful modulation of disease activity by nutritional changes will depend on understanding the mechanisms of these differential pathologic processes.
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PMID:Nutritional factors and autoimmunity. III. Zinc deprivation versus restricted food intake in MRL/1 mice--the distinction between interacting dietary influences. 698 39

Department of molecular basis of semiotics was organized in 1986. The main task of the department was to work out new approaches in estimation of the state of immune and blood system at the tissue, cell and molecular levels, using biochemical, biophysical and molecular biology techniques. There are several main directions of scientific investigations at the department. Most informational methods were collected in "immunological portrait" for differential diagnostic and complex investigation of the immune system of autoimmune patients. This group of techniques was used to study changes in the immune system of Kievites after the Chernobyl disaster. A decrease of complement and thymic serum activity was detected. Antibodies against nuclear components appeared in 20% of donors. And a higher of circulating immune complex of low molecular weight was observed. Low level of thymic serum activity in blood of autoimmune patients with rheumatoid arthritis, lupus erythematosus, diabetes, herpes and other depends on the appearance of zinc-independent timuline inhibitor less then 2000 D. Another kind of thymic hormone inhibitors was detected in thymectomized adult mice. Its effect disappears when zinc added in blood rather due to competition for lymphocyte surface receptors timuline and its inactive analogue than other mechanism. Therapeutic effect of UV irradiation of patients' blood was shown to be closely connected with the changes in thymic serum activity in respect to stabilization of thymic hormone/inhibitor ratio. The immunochemical techniques were used to detect and investigate tumor-associated chromatin antigens in human and animal tumor cells. Antigens not found in normal tissues were detected when using rabbit antibodies against chromatin of rat hepatocarcinoma and human colon and carcinoma.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Department of the molecular bases of semiotics]. 757 Oct 65

Autoantibodies to Ro/SSA occur in nearly half of the patients with systemic lupus erythematosus and are associated with lymphopenia, photosensitive dermatitis, and pulmonary and renal disease, which suggests that they have an immunopathologic role. The majority of Ro/SSA precipitin-positive patients produce serum antibodies that bind to the 60-kD and 52-kD Ro/SSA proteins. We previously isolated and determined the nucleotide sequence of a cDNA clone that encodes the 52-kD form of the human Ro/SSA protein. In the present study, we have determined the chromosomal location of the gene by in situ hybridization to the end of the short arm of chromosome 11. Hybridization of portions of the cDNA probe to restriction enzyme-digested DNA indicated the gene is composed of at least three exons. The exon encoding the putative zinc fingers of this protein was found to be distinct from that which encodes the leucine zipper. An RFLP of this gene was identified and is associated with the presence of lupus, primarily in black Americans.
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PMID:The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome 11, and its polymorphisms. 809 96

Calreticulin is a new human rheumatic disease-associated autoantigen that plays a multifaceted role in cell biology. In earlier studies, this protein was shown to share an intimate relationship with the Ro/SS-A autoantigen complex, although the nature of this association continues to be debated. Since modulation of the Ro/SS-A autoantigen in epidermal keratinocytes has been implicated in the pathogenesis of subacute cutaneous lupus erythematosus and neonatal lupus erythematosus, we have begun to examine the transcriptional regulation of calreticulin. A 504 bp calreticulin promoter fragment was subcloned into a reporter gene plasmid containing firefly luciferase. Calcium ionophore, heat shock, and heavy metals such as zinc and cadmium were consistently found to increase calreticulin transcriptional activities in A431 cells (a human epidermoid squamous carcinoma cell line) under transient transfection conditions. These studies suggest that (a) calreticulin is regulated at the transcriptional level, and (b) calreticulin, like some other LE-related autoantigens, appears to function as a heat shock/stress-response gene.
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PMID:Calreticulin is transcriptionally upregulated by heat shock, calcium and heavy metals. 867 89

Kidney, liver and bone samples were taken from 19 wolves (Canis lupus) collected from two locations in the Yukon Territory. Liver samples pooled by age and sex were analyzed for 22 organochlorine pesticides and 101 PCB congeners. Individual kidney and liver samples were analyzed for arsenic, cadmium, copper, lead, total mercury, selenium and zinc. Thirteen individual bone samples were analyzed for lead. While most organochlorines were not present at detectable levels in wolf liver, some chlorobenzenes, dieldrin and sigma PCB were present at low levels. PCB congeners 149, 153, 170/190, 180 and 187/182 made up 86% of the total PCBs measured in wolf liver. The hexa- and heptachlorobiphenyls dominated the pattern in wolf liver, while congeners containing less than five chlorine atoms were not detected. The pattern of chlorobenzene and PCB homologues found in wolf liver are more similar to those found in marten (Martes americana) and other carnivores than caribou (Rangifer tarandus), perhaps reflecting similarities in food habits and metabolic capacities. With the exception of cadmium, average element concentrations in all wolf tissues are similar to those found in other arctic carnivores. Cadmium concentrations in wolf liver and kidney were somewhat higher in Yukon wolves than other arctic wolves. This may reflect high cadmium concentrations found in livers and kidneys of moose and some caribou herds in the Yukon. Renal arsenic and bone lead decreased significantly with age in wolves, while renal mercury increased with age. Because the ranges seen are relatively small, and all values are within the range normally seen in wildlife, it is difficult to determine the biological significance of these relationships. Contaminant levels in Yukon wolves are generally low and are similar to those found in other arctic terrestrial carnivores. They do not approach levels that are known to potentially cause adverse effects in animals. Contaminant concentrations found in this study should be considered baseline levels.
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PMID:Contaminant residue levels in arctic wolves (Canis lupus) from the Yukon Territory, Canada. 1063 2


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