Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neuromyelitis optica (NMO or Devic's syndrome) is a rare autoimmune disease, previously considered a multiple sclerosis variant. The most important laboratory and clinical features are optic myelitis and transverse myelitis, associated with neuromyelitis optica-IgG antibody (NMO-IgG) positivity. Subsequent to this immunological test being available, different groups have described the not-so-rare comorbidity of neuromyelitis optica with other systemic autoimmune diseases, systemic lupus erythematosus with secondary anti-phospholipid syndrome (APS) in particular. We describe a patient meeting both the classification criteria for primary APS and the new diagnostic criteria for neuromyelitis optica. It's important to diagnose NMO syndrome as both optic neuritis and transverse myelitis were also considered neurological complications of antiphospholipid syndrome. NMO-IgG is a new and fundamental test to decide if immunosuppressant therapy is warranted for such patients.
Lupus 2010 Oct
PMID:Devic's syndrome and primary APS: a new immunological overlap. 2050 34

We present two patients with neuromyelitis optica (NMO; Devic's syndrome), one associated with systemic lupus erythematosus and the other with Hashimoto thyroiditis. Devic's syndrome, whose initial symptoms and signs mimic those of multiple sclerosis, can be associated with other autoimmune diseases. We emphasize the importance of ruling out other entities throughout the follow-up. NMO is seldom described in patients with lupus, which may be due to the rare occurrence of this association sometimes leading to its misdiagnosis.
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PMID:Association of neuromyelitis optic (NMO) with autoimmune disorders: report of two cases and review of the literature. 2053 9