Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Decreased activity of T-suppressor cells plays an important role in the pathogenesis of lupus erythematosus disseminatus. The authors investigated the in vitro effect of levamisole on the histamine inhibited E-rosette forming T-lymphocyte subpopulation in patients affected by LED and in healthy persons. Histamine significantly inhibited the E-rosette forming T-lymphocyte subpopulation in the patient group as compared to controls. This effect of histamine could be reversed by levamisole. It may be anticipated that the E-rosette forming T-cell subpopulation which can be inhibited by histamine is identical to histamine-receptor carrying T-lymphocyte subpopulation with suppressor properties. The possible mechanisms of histamine induced inhibition of E-rosette forming T-cells has been discussed on the basis of literary data.
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PMID:The in vitro effect of levamisole on histamine inhibited E-rosette forming T-lymphocyte subpopulation in patients affected by disseminated erythematosus lupus. 622 May 89

Type I interferon is an essential component of the brain's innate immune defence, conferring protection against viral infection. Recently, dysregulation of the type I interferon pathway has been implicated in the pathogenesis of a spectrum of neuroinfectious and neuroinflammatory disorders. Underactivity of the type I interferon response is associated with a predisposition to herpes simplex encephalitis. Conversely, a group of 'interferonopathic' disorders, characterized by severe neuroinflammation and overactivity of type I interferon, has been described. Elucidation of the genetic basis of these Mendelian neuroinflammatory diseases has uncovered important links between nucleic acid sensors, innate immune activation and neuroinflammatory disease. These mechanisms have an important role in the pathogenesis of more common polygenic diseases that can affect the brain, such as lupus and cerebral small vessel disease. In this article, we review the spectrum of neurological disease associated with type I interferon dysregulation, as well as advances in our understanding of the molecular and cellular pathogenesis of these conditions. We highlight the potential utility of type I interferon as both a biomarker and a therapeutic target in neuroinflammatory disease.
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PMID:Type I interferon dysregulation and neurological disease. 2630 51