Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We describe a middle-aged lady with systemic lupus erythematosus who presented with chronic left knee monoarthritis without constitutional symptoms. The histology of synovial tissue taken at arthroscopy showed acute inflammation and Erysipelothrix rhusiopathiae, identified with some difficulty, was isolated from the enrichment broth only. Blood cultures were negative. Her history revealed significant exposure to pond fish. She responded well to intravenous penicillin and remains well 12 months later.
Lupus 2003
PMID:Chronic monoarthritis of the knee in systemic lupus erythematosus. 1272 59

A remarkable spectrum of clinical expressions of cutaneous leishmaniases is observed in humans ranging from nodular, hyperkeratotic, sporotrichoid, erysipeloid, zosteriform, eczematoid, warty, impetiginized and lupoid forms. Uncommon forms may also be observed. This case describes a 55-year-old lady who apparently looked liked offering from systemic lupus erythematosis due to butterfly distribution of a rash on face. She was misdiagnosed till laboratory tests including histopathology revealed that her lesion was due to cutaneous leishmaniases. Due to cosmetically sensitive site, treatment was started with antimonials and she improved considerably in 3 weeks with diminution in swelling and rubescence.
 ...
PMID:Butterfly rash due to cutaneous leishmaniasis. 1799 56

A 76-year-old man with a medical history of rheumatoid arthritis, lupus intersititial nephritis, and steroid therapy was found at first-stage revision total knee arthroplasty to have Erysipelothrix rhusiopathiae (a zoonotic pathogen normally associated with pigs and fish) infection of the arthroplasty. He had a history of potential occupational exposure to the organism. On literature review, we found only 3 other case reports of E rhusiopathiae linked to septic arthritis in humans. This unique case of an infected joint arthroplasty further illustrates the pathogenicity of E rhusiopathiae in humans.
 ...
PMID:Erysipelothrix rhusiopathiae infection of a total knee arthroplasty an occupational hazard. 1851 83

Through its anatomical, topographical, and functional distinctiveness, more than all other parts of the body, the hand is the interface between humans and their environment. All types of stimulus produce cutaneous signs in the hands, notably cold, light, pressure, contact, etc. Exposure to light makes it the region where photodermatosis is expressed, but also a particular site for cutaneous carcinogenesis. The countless chemical substances that the hand encounters can create specific or particular diseases in this location (irritative dermitis, contact eczema, hyperkeratosis, atrophy, etc.). The hand is also the site of infectious dermatosis transmission (erysipeloid, orf, mycobacteriosis, etc.), sometimes exotic (chromomycosis, histoplasmosis), and the site of plant penetration (protothecosis or more commonly thorns and splinters). The complexity of its vascularization and its many bones, joints, and tendons explain why it is a preferred area for signs of systemic diseases (diverse forms of lupus, dermatomyositis, inflammatory rheumatism, etc.). The nail unit alone shows innumerable signs of exogenic diseases, but also reflects certain internal diseases localized here with often characteristic signs. Here more than anywhere else, dermatology opens out to all of medicine.
 ...
PMID:[Hand for the dermatologist]. 2118 84