Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: glomerulonephritis, arthritis, serositis, a florid discoid rash, lymphopenia, oral ulcers, the development of high titers of antinuclear antibodies, and antidouble stranded DNA antibodies. Furthermore, his admission was complicated by the development of life threatening myopericarditis and vasculitis. This case is notable for the clinical severity and nature of multiorgan lupus involvement from hepatitis C antiviral therapy. Clinical signs of SLE have resolved and anti DS DNA has normalized.
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PMID:Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C. 1852 29

Myocarditis and pericarditis are identified at autopsy in up to 50% of patients with systemic lupus erythematosus. However, clinical symptoms of heart failure are unusual, occurring in only 5%-7% of patients. Drug-induced lupus is rare and typically causes classic lupus symptoms of rash, fever, pleuritis, renal insufficiency, and arthritis. We present an unusual case of drug-induced lupus from chronic phenytoin use in a man who presented with symptoms of fulminant myopericarditis. To our knowledge, this is the first such case reported in English.
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PMID:Fulminant myopericarditis from phenytoin-induced systemic lupus erythematosus. 1893

A 15-year-old African-American boy presented with unilateral decrease in vision following an episode of myopericarditis. His ocular examination was significant for diffuse retinal oedema and intraretinal haemorrhages. He was diagnosed with a central retinal vein occlusion and was referred to rheumatology for further evaluation following negative hypercoaguable studies. He was later found to have systemic lupus erythematous. Approximately 8 months after presentation, the patient's vision improved and remained stable at 20/40.
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PMID:Acute central retinal vein occlusion following episode of myopericarditis in an adolescent patient. 2390 77

We describe herein a 61-year-old African American woman who presented with takotsubo cardiomyopathy preceded by lupus myopericarditis. The case highlights the importance of the association between pericarditis and takotsubo cardiomyopathy. This new stressor adds to the existing evidence that these two entities may coexist and do not have to be mutually exclusive.
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PMID:Lupus myopericarditis as a preceding stressor for takotsubo cardiomyopathy. 2589 4