Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antibodies to SS-A/Ro have been proposed to be a serologic marker for the neonatal lupus syndrome, which is characterized by congenital heart block or cutaneous lupus or both. The antibodies occur in the mother and are transiently found in the child's serum. We examined an unselected series of 12 children with idiopathic CHB, isolated in 10 children and with cutaneous lupus lesions in two. Six of these children and their mothers were studied during the child's neonatal period, and six were studied retrospectively. All six neonates had SS-A/Ro autoantibodies. Nine of 12 mothers had SS-A/Ro autoantibodies. Of the seropositive mothers, one had systemic lupus erythematosus, two had sicca syndrome, one had photosensitivity, one had arthralgias, and four were asymptomatic. We propose that congenital heart block may be related to transplacental passage of maternal SS-A/Ro antibodies and that neonatal lupus may be the most common cause.
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PMID:Autoantibodies to SS-A/Ro in infants with congenital heart block. 664 24

Eighty-eight untreated systemic lupus erythematosus patients collected from rheumatology services were studied for the presence of discoid, molar and vasculitic lesions and photosensitivity. Their sera were examined for antibodies to native deoxyribonucleic acid (nDNA), nuclear ribonuclear protein (nRNP), the non-nucleic acid nuclear macromolecule Sm, the nuclear and cytoplasmic macromolecules La(SSB) and the predominantly cytoplasmic macromolecule Ro(SSA). These studies demonstrated that 42% of the lupus patients possessed nDNA; 36% nRNP; 24% Ro(SSA) and 9% anti La(SSB) antibodies. Six patients failed to demonstrate significant antinuclear antibody titers (mouse liver substrate), and 4 of these possessed anti Ro(SSA) antibodies. Correlation to the cutaneous lesions among this lupus population possessing various serum antibodies revealed a trend toward photosensitivity and molar dermatitis in the Ro(SSA), La(SSB), Ro/la and the ANA negative, ANA negative/Ro positive groups of lupus patients.
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PMID:Serum autoantibodies in systemic lupus erythematosus and correlation with cutaneous features. 698 4

Detection of anticytoplasmic antibodies of Ro specificity has been a valuable aid in identification of a subpopulation of patients with systemic lupus erythematosus (SLE). Characteristics of this group of patients have been dermatosis, photosensitivity, hypergammaglobulinemia, positive rheumatoid factor, and usually absence of fluorescent antinuclear antibodies done by conventional methods. The findings of these three patients add further evidence that, in addition to presence of other manifestations of SLE, the dominant feature is a cutaneous eruption. This became marked and disseminated during exacerbations usually following sun exposure. Such features distinguish these patients from those with discoid lupus erythematosus (DLE) or classical SLE, although at times features of either may be present. Concomitantly, there were selective histopathologic and immunopathologic changes. An unusual finding was a variability in lupus band test dependent upon the state of the disease. Likewise, serologic reactions exhibited a wide range of variability. The results suggest three phases of the disease: chronic active, acute, and treated inactive. Despite acute episodes, including development of nephrotic syndrome in one patient, there was satisfactory response to moderately high doses of corticosteroids and antimalarials.
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PMID:Systemic lupus erythematosus with anti-Ro antibodies: clinical, histologic and immunologic findings. Report of three cases. 704 73

The authors report two cases with both true vitiligo and cutaneous lupus erythematosus (LE). The latter was found only on the vitiliginous areas on both exposed and non-exposed skin. A study of the literature shows that this association is very rare and, like the association between vitiligo and antinuclear antibodies, not statistically significant. It is therefore not possible to explain the pathogenesis of this association by a common autoimmune theory, although vitiligo is well known to coexist with other autoimmune disorders and although antimelanocyte antibodies are exceptionally found in certain cases of vitiligo. The coexistence of lupus erythematosus and vitiligo must be clearly distinguished from post lupus depigmentation which is much more common. In the latter there is clinically an irregular hypomelanosis and an atrophic epidermis and, histologically, there is a pigmentary incontinence with an increased number of melanocytes. Even if it is fortuitous, the appearance of LE lesions on light exposed vitiliginous areas may be explained by the common photosensitivity of these two disorders. However, this superimposition does not explain the common points between these two diseases nor the localization on non-light exposed skin. The localizing role of vitiligo in these exceptional cases could represent a more complex disorder of the dermo-epidermal junction. This disorder could affect more than the melanocytic system and subsequently favour the occurrence of the LE. Nevertheless, the mechanism of this coexistence still remains unknown.
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PMID:[Association of lupus erythematosus and vitiligo (author's transl)]. 723 2

Instrumentation for studying action spectra in controls and various light-associated diseases is described. This study summarizes tests performed with a prism grating monochromator during the last 10 yr. There were 68 photodermatoses studied: xeroderma pigmentosum (XP) (1), lupus erythematosus (LE) (12), polymorphous light eruption (PLE) (23), solar urticaria (4), actinic reticuloid (2), halogenated salicylanilide photosensitivity and persistent light reactors (11), psoralen photosensitivity (6), and porphyria (9). A normal minimal erythema dose in the UVB (below 320 nm) was generally observed in polymorphous light eruption and lupus erythematosus. The most exquisite photosensitivity for delayed erythema was observed in actinic reticuloid, which in one case was 25-35 times more sensitive in the UVB range which was also observed but to a lesser extent in XP and in persistent light reactors. Persistence of erythema and edema at test sites was observed in XP, PLE, LE, and actinic reticuloid. A delay in development of erythema reaching a maximum at 72 hr was observed in XP and psoralen phototoxicity. Maximum photosensitivity occurred in solar urticaria. Three patients had peak sensitivity in the range of 310-313 nm and the 4th at 460 nm. Photosensitivity in the visible range was detected in 2 patients with solar urticaria, one with actinic reticuloid, and confirmed in 9 patients with porphyria (405 nm). Photosensitivity in the UVA (above 320 nm) occurred to some degree in all groups.
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PMID:Instrumentation and action spectra in light-associated diseases. 725 55

We observed two sisters with lupus-like syndrome with homozygous C3 deficiencies. A 19-year-old woman and her 15-year-old sister developed malar rash, arthralgia, and photosensitivity, but antinuclear antibodies and LE cell preparations were negative. The older sister experienced recurrent bronchitis in her childhood, but the younger sister had no recurrent infections. Serum C3 was not detected immunochemically in either sister, and total complement activity and C3 hemolytic activity were extremely low.
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PMID:Hereditary deficiency of the third component of complement in two sisters with systemic lupus erythematosus-like symptoms. 730 27

The American Rheumatism Association (ARA) clinical criteria have been tested in systemic lupus erythematosus (SLE), progressive systemic sclerosis, polyarteritis nodosa and polymyositis/dermatomyositis. Hospital admissions from a defined population over the same period were studied. Increased weighting of the scores for the features showing the greatest specificity is suggested. These features are discoid lupus, alopecia, photosensitivity, LE cells and/or antinuclear antibody (ANA) and oral ulcers. Inclusion of histological evidence increased the sensitivity of the SLE scores.
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PMID:Testing clinical criteria for systemic lupus erythematosus in other connective tissue disorders. 734 70

From 1950 through 1975, 27 patients at the Mayo Clinic, Rochester, Minn, had coexistent psoriasis and lupus erythematosus (LE). Of the 27 patients, ten had systemic LE (SLE), 13 had discoid LE, and four had drug-induced LE or an SLE-like syndrome. The onset of psoriasis preceded LE in ten patients and was concomitant with it in six. Photosensitivity was noted in 23 patients. In 20 patients, the lesions of psoriasis and LE remained clinically distinct. Morphologic overlap and clinical interaction occurred in seven patients in whom the disorders were severe and complicated by a third disease. Generally, this latter group had extensive psoriasis, prominent photosensitivity, and a poor response to therapy.
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PMID:The coexistence of psoriasis and lupus erythematosus. An analysis of 27 cases. 737 2

A study was done that involved 46 patients with high-titer serum antibody to ribonucleoprotein (RNP). Common cutaneous manifestations included swollen hands or sclerodactyly (50 percent), cutaneous lupus erythematosus (48 percent), periungual telangiectasia (46 percent), alopecia (46 percent), dyspigmentation (28 percent), photosensitivity (28 percent) and vasculitis (22 percent). Frequent systemic characteristics included Raynaud phenomenon (93 percent), arthritis or arthralgia (91 percent), adenopathy (43 percent), vascular headaches (35 percent), serositis (35 percent), hoarseness (28 percent), myositis (26 percent), sicca syndrome (24 percent), renal disease (17 percent) and central nervous system disease (9 percent). Associated laboratory findings included antinuclear antibodies (100 percent), epidermal nuclear lgG deposition (91 percent), hypergammaglobulinemia (78 percent), esophageal dysmotility (61 percent), abnormal pulmonary function (59 percent), rheumatoid factor (57 percent), lupus erythematosus cells (37 percent), positive lupus band test (34 percent), hypocomplementemia (28 percent) and elevated anti-nDNA (21 percent). It appears that patients with high-titer anti-RNP (without appreciable amounts of "anti-Sm") have a high prevalence of Raynaud phenomenon and a low prevalence of progressive renal insufficiency and severe central nervous system disease.
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PMID:Mixed connective tissue disease. 738 33

Cutaneous photosensitivity diseases may be idiopathic, produced by endogenous photosensitizers, or associated with exogenous photosensitizers. Those caused by exogenous agents include phototoxicity, photoallergy, and the exacerbation or induction of systemic disorders in which photosensitivity is a prominent clinical manifestation. Phototoxic disorders have a high incidence, whereas photoallergic reactions are much less frequent. The action spectra for most phototoxins and photoallergens lie in the UVA range. Phototoxic and photoallergic reactions can be distinguished on the basis of pathogenesis, clinical characteristics, diagnosis, and management. Drugs capable of causing phototoxic reactions include psoralens, porphyrins, coal tar, antibiotics, and nonsteroidal antiinflammatory agents. Drugs capable of causing photoallergic reactions include topical antimicrobial agents, fragrances, sunscreens, nonsteroidal antiinflammatory agents, plants, and psychiatric medications. Drug-induced systemic diseases in which photosensitivity is a prominent component include drug-induced lupus erythematosus, porphyria, and pellagra.
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PMID:Cutaneous photosensitivity diseases induced by exogenous agents. 767 88


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