Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 35 patients, 21 women and 14 men, with light-sensitive psoriasis deteriorating in summertime on solar exposure were clinically examined in detail and subjected to standardized phototest procedures. This included provocations with UVB and high dosage UVA exposures by the use of an UVASUN 3000 lamp, and also photopatch testing. All patients had long-standing psoriasis and had observed a photosensitivity from 2 to 40 years (men 11.4 yr). The photosensitivity had remained unchanged since its appearance in 21, had worsened in 13 and improved in only 1. A hardening phenomenon was noticed by 11 patients. Exacerbation of psoriasis from sun exposure was observed mostly on the back of the hands and forearms, followed in frequency by the legs, face, chest and back. No cases of other light-sensitive disorders, e.g. vitiligo, porphyrias or connective tissue diseases such as lupus erythematosus were detected. 5 patients used drugs capable of inducing photoallergy but no such reactions could be substantiated. Photopatch testing revealed no photoallergic contact reactions. Skin type distribution was normal, with no overrepresentation of skin type I-II which was registered in 26% (9/35) and skin type III-IV in 74% (26/35). 18/35 patients had a history of PMLE with a secondary evolution of psoriasis lesions. The PMLE reaction was most easily provoked by high-dosage UVA exposures (12/18). 17/35 had no history of a preceding PMLE reaction and, after provocations, new psoriasis lesions appeared successively, most easily provoked by UVB (9/17). The distribution of skin types was about the same in the two groups.
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PMID:Photosensitive psoriasis--clinical findings and phototest results. 358 51

Cutaneous photosensitivity diseases may be idiopathic, produced by endogenous photosensitizers, or associated with exogenous photosensitizers. Those caused by exogenous agents include phototoxicity, photoallergy, and the exacerbation or induction of systemic disorders in which photosensitivity is a prominent clinical manifestation. Phototoxic disorders have a high incidence, whereas photoallergic reactions are much less frequent. The action spectra for most phototoxins and photoallergens lie in the UVA range. Phototoxic and photoallergic reactions can be distinguished on the basis of pathogenesis, clinical characteristics, diagnosis, and management. Drugs capable of causing phototoxic reactions include psoralens, porphyrins, coal tar, antibiotics, and nonsteroidal antiinflammatory agents. Drugs capable of causing photoallergic reactions include topical antimicrobial agents, fragrances, sunscreens, nonsteroidal antiinflammatory agents, plants, and psychiatric medications. Drug-induced systemic diseases in which photosensitivity is a prominent component include drug-induced lupus erythematosus, porphyria, and pellagra.
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PMID:Cutaneous photosensitivity diseases induced by exogenous agents. 767 88

To know the clinical characteristics of male patients with systemic lupus erythema(SLE), the clinical and laboratory indications of 46 male SLE patients were analysed and compared with those of 269 females. The results showed that: 1. There was family history in 21.28% of male patients. 2. As compared with female SLE patients, pleurisy, pericarditis, lupus nephritis(LN), proteinuria, renal failure, the incidence of types, V-LN and the positive rate of Sm antibody were more common in males while facial erythema, Raynaud's phenomenon and photoallergy were less in male. There were statistical differences between the male and female. 3. The confirmed diagnosis for the male SLE was delayed. The recovery rate was lower and the mortality was higher in males. These findings suggest that evident genetic predisposition, atypical clinical manifestations, serious renal injury and the worse prognosis are the characteristics of male SLE.
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PMID:[A clinical study on male patients with systemic lupus erythema]. 1221 33

Benzophenones are common causes of photoallergy and are increasingly used in products other than traditional sunscreens. Patients may be unaware of any sunscreen exposure when using a product such as shampoo containing benzophenone. Benzophenones also may produce photoallergic contact urticaria, in addition to delayed contact and photocontact dermatitis, which may complicate the clinical presentation. Allergy to benzophenone should be considered in the diagnosis of patients with patchy erythema of the face and neck that is not typically eczematous and that may otherwise be attributed to a rosacea diathesis, lupus erythematosis, or simple flushing. Patch and photopatch testing are indicated to evaluate these patients for allergy to benzophenone.
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PMID:Facial erythema as a result of benzophenone allergy. 1457 46