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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The occurrence of multinucleated epidermal giant cells (MEGCs) with more than three clumping nuclei has been considered an episodic and exceptional phenomenon in inflammatory skin diseases. However, we have found them in 97 histologic specimens obtained from inflammatory lesions. They appeared in 88 of 196 biopsy specimens from a group of patients with chronic eczema or prurigo. In pruriginous lesions alone, they were found in 67 (74%) of 90 specimens. On the other hand, MEGCs were found rarely in lichen amyloidosus (2/11), dermatitis herpetiformis (1/6), erythema multiforme (1/11), pustular psoriasis (1/17), lichen planus (1/29), lupus erythematosus (1/30), and pustulosis palmaris et plantaris (1/41), probably representing just a chance occurrence in these dermatoses.
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PMID:Multinucleated epidermal giant cells in inflammatory skin diseases. 745 74

A range of antibiotics has been shown to modify host functions apart from the antimicrobial potency. They may directly influence phagocyte and lymphocyte function, as well as chemotaxis. Effects on the generation and release of various cytokines involved in the inflammatory process have been studied both in vivo and in vitro. However, the molecular mechanisms have not been elucidated in detail. It is suggested that antibiotics can exert immunopharmacological effects on the basis of structure-activity relationships independent of their antibacterial activity. We present a collection of clinical studies and case reports dealing with the potential benefits of systemic antibiotics in the treatment of selected dermatoses which have primarily been classified as non-infectious. Generally accepted treatments such as dapsone in dermatitis herpetiformis and leukocytoclastic vasculitis or chloroquine in lupus erythematosus have not been considered. Based on existing clinical trials with a higher number of cases the following antibiotics have been shown to be effective: erythromycin in bullous pemphigoid and pityriasis rosea as well as tetracyclines in pemphigus vulgaris, bullous pemphigoid and pustulosis palmaris et plantaris. However, most reports have to be viewed critically due to the uncontrolled study design, particularly in dermatoses with a tendency to spontaneous resolution. Despite this lack of evidence-based data, it is important for the clinician to know about the potential use of antibiotics for various skin disorders as a primary treatment option or steroid-sparing therapeutic adjunct. In clinical practice the use of antibiotics depends on various factors including the severity of the disease, the patient's age, contraindications to conventional therapeutic regiments and economic considerations.
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PMID:[Oral antibiotics with antiinflammatory/ immunomodulatory effects in the treatment of various dermatoses]. 1221 68

What's new in medicine in 2007? Find out what has changed in medicine in 2007 in the field of inflammatory and autoimmune diseases. The year has been productive with many fundamental advances. 2007 was the year of genetics in autoimmune diseases (rheumatoid arthritis, lupus, scleroderma, vascularities, etc.), coming notably from work by the WTCCC. The comprehension of inflammatory diseases is based on increasingly detailed knowledge of epigenetic regulation and posttranscriptional mechanisms. The small RNA play a fundamental role and potentially offer many therapeutic applications.Sex and stress play a role in the appearance of inflammatory diseases. The mechanisms are progressively being better understood.More and more illnesses have autoimmune mechanisms, such as emphysema in the ex-smoker or pustulosis palmaris et plantaris. The revolution in biological therapies is continuing to grow. Medications that modulate innate immunity are being evaluated in inflammatory, allergic, and neoplastic diseases. Other, sometimes surprising options such as arsenic are now possible.
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PMID:[What's new in medicine in 2007?]. 1867 38