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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lupus erythematosis is a nodular skin lesion that usually occurs on the inner surfaces of the extremities, and is 5-7 times more common in women than in men, particularly between 20-30 years of age. It is diagnosed by biopsy since the associated symptoms of malaise, fever, and arthralgia are variable. Known agents to induce lupus are streptococcal infection, sarcoidosis, tuberculosis, mycoses, medications particularly sulfa and oral contraceptive steroids, and a variety of other infections and allergies. A table is included in this review showing 8 cases of lupus erythematosus reported in the literature where oral contraceptive steroids were proved to be the etiologic factor, either by withdrawing and repeating pill prescription or by skin tests. The review ends with a list of other dermatological side effects of the pill, such as chloasma, acne, vaginal moniliasis, herpes, photosensitivity, and urticaria.
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PMID:[Etiologies of erythema nodosum (a little known etiology: estro-progestagens)]. 101 56

A review of medical history concerning case history reports of adverse clinical manifestations of hormonal contraceptives is presented. The unusual complicatons described are: gingivitis, dilation of the ureters, masculinization of the female fetus, candidiasis, ischemic colitis, megaloblastic anemia, chorea, alopecia, chloasma pigmentation, prophyria, photosensitivity, herpes gestationis, lupus, erythematous syndrone, erythema modosum and corneal irritation. The pathophysiology of the lesion and its relation to hormone action are presented.
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PMID:Unusal signs and symptoms associated with oral contraceptive medication. 110 27

The clinical presentation of certain dermatologic conditions differs between women and men; this may be especially true when women are perimenstrual or pregnant. Skin diseases that erupt or become aggravated during the perimenstrual period include autoimmune progesterone dermatitis and melasma. Dermatologic conditions that may be exacerbated perimenstrually include acne vulgaris, rosacea, lupus erythematosus, psoriasis, atopic eczema, lichen planus, dermatitis herpetiformis, erythema multiforme, and urticaria. The hormonal effects of increased cutaneous vascularity, seborrhea, and dermal edema during the perimenstrual period may account for the eruption of or increase in severity of these diseases. Clinical presentation, differential diagnoses, and treatment options for select cutaneous conditions are discussed.
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PMID:Clinician's Photo Guide To Recognizing and Treating Skin Diseases in Women: Part 1. Dermatoses Not Linked to Pregnancy. 974 12

A review of cutaneous reactions associated with oral contraceptives intended to help the practitioner is presented. The skin responses to gestagens depend upon the sensitivity of the patient, the nature of the gestagen, and the ratio of progestogen to estrogen. Reactions are classified according to their physiologic mechanisms: hormonal effects, immune response, altered porphyrin metabolism, and miscellaneous skin problems. Some of the reactions associated with pseudopregnancy include herpes gestationis, melasma, vaginal candidiasis, cholestatic jaundice, alopecia, and possibly hypertophic gingivitis, neurofibromatosis, and telangiectasia. Hormonal effects include acneform eruptions, diffuse hair loss, and decrease of sebum production. Adverse effects exerted via the immune system include: candidiasis, decreased delayed skin-test reactivity, increased viral infections, flare of lupus erthematosus, erythema nodosum, erythema multiforme, photodermatitis, and herpes gestationis. Altered porphyrin metabolism effects include induction of porphyria and of variegate porphyria. Beneficial effects of oral contraceptives include improvement of acne, lessening of premenstrual flaring of aphthous ulcers, and improvement of Fox-Fordyce disease with estrogenic preparations. There is an unclear association between seborrhea, epithelial inclusion cysts, and hidradenitis supporativa and contraceptive therapy.
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PMID:Desirable and undesirable cutaneous effects of oral contraceptives. 1222 28

Melasma, moniliasis, photosensitivity, alopecia, and bullous eruptions are the most frequently reported dermatological side-effects of oral contraceptives. Other conditions reported occasionally as resulting from or being aggravated by these drugs have been acne, hidradenitis suppurativa, seborrhea, and Fox-Fordyce disease. Very rarely erythema nodosum, purpura, lupus erythematosus, increase in number of moles, and hypertrophic gingivitis have been associated. Melasma occurs within months or after a year in most cases, and may pass off gradually after stopping the drug. A malnutrition factor has been suggested and vitamin-B used as therapy. Photosensitivity may be a factor in melasma or occur independently. A period of months is required for the development of moniliasis. Family planning centers with their large numbers of patients should be a help in solving these problems but other specialists are needed also.
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PMID:Oral contraceptive and dermatology. 1230 10