Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a 46-year-old woman with a systemic lupus erythematosus complicated with a lupus panniculitis. The patient developed initial deep breast nodules secondarily completed by superficial erythematosus and keratotic cutaneous lesions. Neoplasia was ruled out by X-ray and echographic investigations. Both subcutaneous and skin biopsies were consistent with the diagnosis of lupus mastitis. Lupus mastitis is a form of lupus panniculitis seldom associated with systemic lupus. A breast neoplasia should be ruled out by appropriate investigations and deep biopsies. The first-line treatment is based on antimalarial drugs.
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PMID:[Lupus mastitis associated with severe systemic erythematosus lupus]. 1883 48

Lupus mastitis (LM) is a rare presentation of lupus erythematosus profundus or lupus panniculitis, an unusual and rare clinical variant of lupus erythematosus itself in which the inflammatory reaction occurs primarily in the deep subcutaneous adipose. Although not required for diagnosis, essentially all cases of LM present with systemic or discoid lupus. The etiology is uncertain. Histologically it is defined by a lymphocytic lobular panniculitis and a characteristic hyaline sclerosis of the adipose tissue. Treatment is primarily medical due to exacerbation of disease by surgical intervention. A high index of suspicion, and familiarity of the histologic findings, is therefore required to make an accurate diagnosis and prevent further unwarranted diagnostic procedures. Herein, we provide a literature-based review of the clinical, radiologic, and pathologic findings of LM and its treatment and prognosis with the addition of a case for the literature.
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PMID:Lupus mastitis: a clinicopathologic review and addition of a case. 1909 67

Lupus mastitis is a form of lupus profundus that is seen in patients with systemic lupus erythematosus. It usually presents as a swelling (or swellings) in the breasts, with or without pain. The condition is recurrent and progresses along with the underlying disease, with fat necrosis, calcification, fibrosis, scarring, and breast atrophy. Lupus mastitis is often confused with malignancy and lymphoma and, in our part of the world, with tuberculosis. Confusion is especially likely when it occurs in an unusual clinical setting. In this article, we present a case that presented with unique radiological, pathological, and clinical features. Awareness of the various manifestations of lupus mastitis is essential if unnecessary interventions such as biopsies and surgeries, and their consequences, are to be avoided.
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PMID:Lupus mastitis - peculiar radiological and pathological features. 1988 Oct 78

Lupus mastitis is an uncommon presentation of lupus erythematosus profundus or lupus panniculitis, a rare variant of lupus erythematosus characterized by inflammation of the subcutaneous fat. Lupus mastitis can present as single or multiple subcutaneous or deep breast masses, often clinically mimicking malignancy. Although lupus mastitis is rare, with less than 25 cases reported, the histologic features are distinct. Awareness of the entity and familiarity with the histologic features allow for accurate diagnosis and appropriate patient management. It most commonly affects women with a mean age at diagnosis of 40 years and an age range of 18 to 70 years. Typical histologic findings in lupus mastitis include a lymphocytic lobular panniculitis with plasma cells and hyaline fat necrosis. The lymphocytic infiltrate can be nodular, diffuse, periductal, and/or perilobular and germinal centers can frequently be identified. Lymphocytic vasculitis is also common. Immunohistochemistry shows a mixed T and B-cell population, with predominantly CD3+ CD4+ T cells intermixed with CD20-positive B cells and polyclonal plasma cells. Most commonly, lupus mastitis is seen in patients with a previous diagnosis of systemic or discoid lupus; however, it can also be the initial presentation of lupus in some patients. We report on 2 cases of lupus mastitis where the clinical impression was to rule out malignancy and review the literature to highlight the key clinicopathologic features.
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PMID:Lupus mastitis: an uncommon complication of systemic or discoid lupus. 2041 Aug 9

A 25-year-old woman with systemic lupus erythematosus presented with multiple palpable masses in both breasts. On mammography multiple, coarse, heterogeneous, microcalcificatons were seen. Histopathologic examination showed inflammation, fibrosis, fat necrosis and dystrophic microcalcifications. Based on these findings the patient was diagnosed with lupus mastitis.
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PMID:[A patient with bilateral microcalcifications on mammography]. 2216 76

Breast involvement is a rare event in SLE patients. The most frequent presentation is lupus panniculitis with skin erythema, tenderness, and parenchymal nodules. However, when breast masses are detected in SLE patients without significant superficial inflammation, it is mandatory to rule out breast carcinoma. Here, we report the case of a 47-year-old woman with an 18-year-long history of SLE, who presented with a suspicious breast mass. Since surgical trauma has been reported to be able to exacerbate breast inflammation in lupus mastitis, an ultrasound-guided minimally invasive Mammotome biopsy was performed to obtain tissue samples for histological and immunohistochemical examinations. Histology was consistent with lupus mastitis. The patient was already on mycophenolate mofetil and hydroxychloroquine. At the latest follow-up visit 6 years later, no progression of the breast lesion was observed.
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PMID:Lupus mastitis in systemic lupus erythematosus: a rare condition requiring a minimally invasive diagnostic approach. 2223 Apr 23

The authors present a case of lupus mastitis which was initially diagnosed following an incisional biopsy of a breast lump, with similar pathology found 2 years later after an ultrasound guided biopsy of the same lump. The woman had been diagnosed 7 years before with systemic lupus erythematosus. The radiological and pathological features are presented in this report with discussion of similar cases in the literature.
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PMID:Lupus mastitis: a mimicker of breast carcinoma. 2266 97

Lupus mastitis (LM) is a rare benign inflammatory condition characterized by inflammation of the deep subcutaneous adipose tissues of the breast. It can be seen in patients with a known history of systemic lupus erythematous or discoid lupus or rarely can be the initial presentation of these diseases. Histologically, the most common findings are the presence of a dense lymphoplasmacytic infiltration of lobules and hyaline fat necrosis. Radiologic characteristics of LM can mimic a malignant lesion. However, because histologic features of this lesion have been well defined, correlation with clinical history is important to arrive at an accurate diagnosis and, therefore, deliver appropriate patient management. Herein, we present a review of LM with emphasis on clinicopathologic findings and differential diagnosis.
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PMID:Lupus mastitis: a review. 2319 Jun 81

Lupus Mastitis (LM) is a rare presentation of lupus panniculitis involving the breast. Because it often presents as a tender palpable mass, a workup for malignancy usually ensues. It is well documented that surgery may worsen the condition; therefore, it is important to consider LM in the differential of a palpable breast mass in patients with systemic lupus erythematosus (SLE). Currently, management of LM remains primarily medical. We discuss the multi-disciplinary work-up of LM, and further describe its appearance on serial Magnetic Resonance (MR) exams.
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PMID:Serial MR findings and comprehensive review of bilateral lupus mastitis with an additional case report. 2337 75

Granulomatous mastitis (GM) is a rare benign mammary lesion in which autoimmunity and hyperprolactinemia are considered possible etiological factors. GM has a high frequency of relapse and may lead to chronic ulceration and fistula if not treated properly. Here we report a case of a 22-year-old systemic lupus erythematosus (SLE) patient with three years' disease duration, stable on prednisone and hydroxychloroquine, who was found to have prolactinoma and recurrent GM after she discontinued medication on her own accord. The patient subsequently recovered and remained free of GM relapse under treatment of prednisone, hydroxychloroquine and bromocriptine. Though autoimmune disorders and prolactinoma were reported in GM, a coexisting condition of SLE, prolactinoma, and granulomatous mastitis has rarely been observed in one patient. We suggest our case as an illustrative example of the complex interaction between autoimmunity, neuroendocrine dysfunction, and manifestations in the breast: Immunological disturbances in the background of SLE, coupled with elevated prolactin levels secondary to a prolactinoma, may have predisposed the patient to the development of GM. The mammary lesion recovered and maintained free of relapse under immunosuppressive and antiprolactinemic therapy.
Lupus 2014 Apr
PMID:An SLE patient with prolactinoma and recurrent granulomatous mastitis successfully treated with hydroxychloroquine and bromocriptine. 2444 5


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