Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In normal human epidermis HLA-DR-antigen is only present on Langerhans' cells and the acrosyringeal epithelium. We investigated the distribution of HLA-DR-antigen in 78 specimens of various skin diseases by an immunoperoxidase method using a monoclonal anti-HLA-DR antibody. HLA-DR-antigen bearing keratinocytes were not only found in lichen planus and mycosis fungoides, as it has been referred previously, but were also observed in some cases of cutaneous B-cell lymphoma, pseudolymphoma, lupus erythematosus, parapsoriasis en plaque, bullous pemphigoid, drug reaction, contact dermatitis, actinic keratosis and verrucous carcinoma. Direct contact of lymphoid cells with keratinocytes was not necessary for Ia-antigen expression.
 ...
PMID:HLA-DR-antigen bearing keratinocytes in various dermatologic disorders. 257 18

The terminology used for white lesions of the oral cavity requires careful definition: the term keratosis is general, covering all lesions which by histological examination show evidence of keratin on the surface, regardless of other detectable lesions; the term leukoplasia is more restrictive, indicating (according to the WHO) white lesions not falling within the context of a known disease = lichen, lupus erythematosus, florid oral papillomatosis, chronic candidiasis, etc. This review chose the diagnostic difficulties of different varieties (planus, warty, erosive) of leukoplasia. In our experience the ambiguity of keratosis may be due to inadequate data from clinical examination and/or histological examination, to the combined existence in a given patient and at the same time of two white lesions of different nature, or to the successive existence at the same place of two lesions with a different clinical and/or histological diagnosis (raising the problem of transformation).
 ...
PMID:[Ambiguous keratosis. The situation of leukoplasia of the oral cavity]. 321 32

Regarding systemic (SLE) and chronic discoid lupus erythematosus (CDLE), the diagnostic value of the lupus band test ist generally accepted. In the literature, however, there are but few obligatory criteria concerning the definition of a positive lupus band. In order to illustrate the influence of sunlight on the evolution of junctional deposits of immunoglobulins, we examplarily studied actinic keratosis (AK) as a chronic light-dependent dermatosis. The junctional deposits in AK were qualitatively and quantitatively compared with the lupus band typical for CDLE. In CDLE we mostly found more distinct band-like junctional deposits of immunoglobulins and complements. Light-dependent, non-specific junctional patterns of immunofluorescence similar to LE, therefore, require clear morphological criteria of immunohistology.
 ...
PMID:[Comparative immunofluorescence study of actinic keratosis and chronic discoid lupus erythematosus]. 332 25

Evidence from several studies has established that a solitary benign lichenoid keratosis evolves from a senile lentigo. This lesion tends to resolve spontaneously with partial or complete regression of the original senile lentigo. In a 2-year period we studied fourteen patients with multiple benign lichenoid keratoses simulating photodermatoses. The original two patients were thought initially to have either cutaneous lupus erythematosus or a drug-induced photodermatitis. All fourteen patients were found to have multiple benign lichenoid keratoses distributed primarily in sun-exposed skin and arising from preexisting senile lentigines. The lichenoid lesions disappear either with topical corticosteroid treatment or spontaneously and are followed by partial or complete regression of the original senile lentigines. This disease entity seems to be fairly common and may be easily confused with photodermatoses.
 ...
PMID:Multiple benign lichenoid keratoses simulating photodermatoses: evolution from senile lentigines and their spontaneous regression. 404 48

214 skin lesions have been analyzed in the paper and 158 cases of Carcinoma basocellulare, 22 cases of Carcinoma planocellulare and 11 cases of melanoma were registered. Concerning localization it has been established that skin of the face is mostly endangered both for malignant and benign lesions. In 10 cases Keratosis senilis, a benign kind of lesion, was diagnosed, Dermatitis post irradiationem was diagnosed in 8 cases and Lupus erythematodus in 5 cases. By histologic analysis the following can be stated: if the degree of degradation and damage of collagen fibers is high, the intensity of lymphoplasm infiltrate density and intensity of mastocyte cells density is reduced. If the degree of decomposition of collagen fibers is lower, the lymphoplasmocyte infiltrates are denser as in the stroma of the lesion as well in edges and in the surrounding dermis. Changes were primarily found in malignant skin lesions, but they are identical in cases of keratosis senilis as a premalignant lesion. However, concerning nonmalignant lesions, depending on exterior factors, long time influence of noxa, collagen fibers and their degree of degradation have an important role in the cell interaction, and more attention should be paid to exploring decomposition of collagen fibers as components of the local immunobiologic reaction of the organism to lesion formation.
 ...
PMID:[Specific inflammatory processes in collagenosis, degenerative and malignant diseases of the skin of the face and neck during aging]. 773 55

A patient with severe ichthyosiform erythroderma and lichenoid histological changes is presented. We discuss the clinical and histological differential diagnosis, including lupus erythematosus, lichenoid drug eruption, lichen planus, graft-versus-host disease, lymphoma, keratosis lichenoides chronica, Netherton's syndrome and ichthyosiform erythroderma. None of these is consistent with the features in our case, which may represent either a hitherto unreported form of ichthyosiform erythroderma or possibly a new entity.
 ...
PMID:Adolescent-onset ichthyosiform-like erythroderma with lichenoid tissue reaction: a new entity? 1135 99

It has been a subject of controversy whether keratosis lichenoides chronica (KLC) is a distinctive inflammatory disease of the skin or whether it represents a manifestation of another well-known disease, such as lichen planus, lupus erythematosus, or lichen simplex chronicus. In search of clear criteria for diagnosis of KLC the entire literature pertinent to the subject was studied and findings clinical and histopathologic as they were telegraphed in them were compared with a patient of my own experience. Review of the literature reveals more than 60 patients in whom the diagnosis of KLC was made. Three categories emerge based on whether the findings presented in a particular article (1) do not permit any diagnosis to be rendered; (2) do allow a diagnosis specific to be made, such as of lichen simplex, lichen planus, or lupus erythematosus; or (3) do not correspond to any disease well defined, such as lichen simplex, lichen planus, lupus erythematosus, but seem to show attributes morphologic, clinically and histopathologically, that are repeatable. Patients diagnosed as having KLC obviously represent a potpourri of different diseases, the most common of them being lichen simplex chronicus, lichen planus, and lupus erythematosus. Fewer than 25 patients reported on, however, presented themselves with lesions very similar to one another clinically, namely, an eruption that involved the face in a manner reminiscent of seborrheic dermatitis and with tiny papules on the trunk and extremities, which assumed linear and reticulate shapes by way of confluence of lesions. Individual papules were infundibulocentric and acrosyringocentric. Findings histopathologic were those of a lichenoid interface dermatitis affiliated with numerous necrotic keratocytes and covered by parakeratosis housing neutrophils in staggered fashion. These patients seem to have an authentic and distinctive condition that is exceedingly rare. In conclusion, the diagnosis of KLC should be made only for patients who present themselves with features clinical and findings histopathologic that resemble closely those of what is summarized in this article under category 3.
 ...
PMID:Keratosis lichenoides chronica: proposal of a concept. 1677 33

The term "interface dermatitis" (ID) involves a specific histological inflammatory pattern that is characterized by a cytotoxic lymphocytic infiltration and a hydropic degeneration of the basal epidermal layer. ID is typically seen in autoimmune skin disorders such as lichen planus (LP), cutaneous lupus erythematosus (CLE), and may also appear during immune reactions against drugs, viruses, and tumors. Recent studies have shown that the type-I IFN system is involved in cutaneous autoimmune diseases characterized by ID. IFNs induce the expression of proinflammatory cytokines and chemokines, which support the cellular immune response. The role of IFNs in ID is supported by a close morphological association between the expression pattern of IFN-inducible proteins and the distribution of CXCR3+ lymphocytes. The IFN-inducible chemokine CXCL10 is expressed in exactly those areas where cytotoxic lymphocytes invade the basal epidermis and cause keratinocyte death. A similar picture can be found in early herpes simplex viral skin lesions and viral warts, but also in "lichenoid" actinic keratosis and invasive squamous cell carcinoma. These data suggest that ID morphologically reflects a common IFN-driven cytotoxic attack affecting the basal keratinocytes under different conditions, which is important for antiviral and antitumor immune response, but is inappropriately activated in autoimmune skin disorders.
 ...
PMID:An IFN-associated cytotoxic cellular immune response against viral, self-, or tumor antigens is a common pathogenetic feature in "interface dermatitis". 1841 11

Few patients with systemic lupus erythematosus have features of verrucous (hypertrophic) lupus erythematosus. A 29-year-old Caucasian woman with a 7-year history of systemic lupus erythematosus developed painful verrucous plaques on the nose. Erythematous, raised, indurated, hyperkeratotic plaques localized on the dorsa of the distal parts of the toes and over the interphalangeal joints of her fingers were also noted. A large, dull-red, indurated plaque with rolled borders on the bridge of the nose was most characteristic. Rapid therapeutic effect was obtained by systemic corticosteroid regimen. This verrucous variant of lupus erythematosus, sometimes clinically resembling actinic keratosis, keratoacanthoma and squamous cell carcinoma, is reviewed.
 ...
PMID:Verrucous systemic lupus erythematosus. 2002 85

Imiquimod (AldaraTM), a Toll-like receptor 7 agonist (TLR7), is known for its unique properties of being an immune response modifier and stimulator. Upon topical application, this TLR7 agonist triggers a cell-mediated immune response predominantly expressed by dendritic cells and monocytes. Local skin irritation at the application site involving erythema, pain, crusting and erosions is common and well documented. On the contrary, the specific histopathologic features associated with these treatment site reactions is not. Herein reported is a case where historical omission of imiquimod use for actinic keratosis complicated the histologic interpretation. We highlight a lupus erythematosus-like microscopic pattern and explore histopathologic features that could help in avoiding a diagnostic pitfall, as well as the relationship between TLR activation, cell-mediated immunity and skin histology.
 ...
PMID:Lupus erythematosus-like imiquimod reaction: a diagnostic pitfall. 2072 30


1 2 Next >>