Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Total number of salmonellosis cases has been gradually falling down since the year 1988. In 2001, 19,881 cases were reported to the sanitary epidemiological stations, incidence rate = 51.5 per 100,000 population (22,799 in the previous year). Over 52% of patients were hospitalized, but percentage of cases with extraintestinal manifestations was higher--over 88%. The seasonal peak was noted in July and August, which was two months later than in 2000. The decreasing trend in confirmation of clinical diagnosis can be observed since 1995 when Salmonella strains were isolated in 91% of patients, but in 2000 only 66% of cases were bacteriologically confirmed. Salmonella Enteritidis was the most frequent type: 88% of cases and 69% of infected healthy persons. Only four other serotypes (Typhimurium, Infantis, Hadar and Virchow) were identified in all of 16 voivodeship of Poland. The age, sex, urban/rural distribution of salmonellosis remain stable. The highest incidence was registered among children one year old (423/100,000). Extraintestinal manifestations of salmonellosis (septicaemia, meningitis, pneumonia, peritonitis, appendicitis and other), were observed in 93 patients with at least one non-fecal specimen culture-positive for non-typhoidal Salmonella. In older patients, other diseases like carcinoma, leukaemia, lupus erythematosus, contributed to Salmonella infection. Twelve of those patients died.
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PMID:[Salmonellosis in Poland in 2001]. 1292 12

Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation and infertility. A biomarker of STI-induced upper tract inflammation would be significant as many women are asymptomatic and delayed treatment increases risk of sequelae. Blood mRNA from 111 women from three cohorts was profiled using microarray. Unsupervised analysis revealed a transcriptional profile that distinguished 9 cases of STI-induced endometritis from 18 with cervical STI or uninfected controls. Using a hybrid feature selection algorithm we identified 21 genes that yielded maximal classification accuracy within our training dataset. Predictive accuracy was evaluated using an independent testing dataset of 5 cases and 10 controls. Sensitivity was evaluated in a separate test set of 12 women with asymptomatic STI-induced endometritis in whom cervical burden was determined by PCR; and specificity in an additional test set of 15 uninfected women with pelvic pain due to unknown cause. Disease module preservation was assessed in 42 women with a clinical diagnosis of pelvic inflammatory disease (PID). We also tested the ability of the biomarker to discriminate STI-induced endometritis from other diseases. The biomarker was 86.7% (13/15) accurate in correctly distinguishing cases from controls in the testing dataset. Sensitivity was 83.3% (5/6) in women with high cervical Chlamydia trachomatis burden and asymptomatic endometritis, but 0% (0/6) in women with low burden. Specificity in patients with non-STI-induced pelvic pain was 86.7% (13/15). Disease modules were preserved in all 8 biomarker predicted cases. The 21-gene biomarker was highly discriminatory for systemic infections, lupus, and appendicitis, but wrongly predicted tuberculosis as STI-induced endometritis in 52.4%. A 21-gene biomarker can identify asymptomatic women with STI-induced endometritis that places them at risk for chronic disease development and discriminate STI-induced endometritis from non-STI pelvic pain and other diseases.
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PMID:Gene Expression Signatures Can Aid Diagnosis of Sexually Transmitted Infection-Induced Endometritis in Women. 3029 92

In lupus enteritis, circulating pathological immune complexes and thrombosis of intestinal vessels may occur, resulting in acute abdominal pain. We report a 24-year-old woman without a history of systemic lupus erythematosus (SLE), admitted for abdominal pain. An exploratory laparotomy found an appendicitis along with ascites. An appendectomy was performed, and the patient was discharged from the hospital two days later. Three days after discharge, the patient was admitted to another hospital due to the persistence of abdominal pain. An abdominal computed tomography scan showed diffuse mesenteric congestion, concentric bowel loops (double halo or target sign) and the presence of free fluid in the peritoneal cavity. Suspecting a rheumatic disorder, the diagnosis of SLE was confirmed by immunological studies. The patient was treated with pulses of methylprednisolone with good results.
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PMID:[Lupus enteritis. Report of one case]. 3185 74