Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients with systemic lupus erythematosus had intermittent episodes of dysphagia associated with severe nonpleuritic chest pain. Esophageal manometry disclosed abnormalities characteristic of diffuse esophageal spasm. The findings suggest that diffuse spasm should be considered in the differential diagnosis of unexplained chest pain and dysphagia in patients with lupus.
JAMA 1979 Oct 26
PMID:Esophageal motor dysfunction in systemic lupus erythematosus. Two cases with unusual features. 48 Jun 25

The child of a woman with discoid lupus erythematosus (DLE) had lesions of DLE develop at the age of 2 months. The original lesions persisted and new lesions continued to develop to date; the child is now 28 months old. In a second child, now 11 months old, a probable lupus erythematosus rash developed at 1 week of age.
JAMA 1977 Nov 21
PMID:Familial lupus erythematosus. 57 51

Numerous tubuloreticular structures were seen on electron microscopic examination of involved and uninvolved skin of a neonate with lupus erythematosus. The patient had characteristic lupus skin lesions at birth that worsened for three months, and then gradually subsided. Their course was associated with systemic illness. Skin biopsy specimen was diagnostic. Direct immunogluorescence of the skin showed no abnormalities. Abnormal serological findings were noted in the mother, who had no overt clinical disease. The significance of these virus-like structures in lupus erythematosus is emphasized by the present case.
JAMA 1976 Jun 21
PMID:Tubuloreticular inclusions in neonatal lupus erythematosus. 94 88

A 73-year-old woman was found to have clinically significant pancytopenia in association with procainamide hydrochloride ingestion. The syndrome, resembling systemic lupus erythematosus, which has been reported to develop in patients treated with this agent, is characterized by mild to moderate anemia and mild to moderate granulocytopenia. Severe granulocytopenia in patients taking procainamide and unrelated to a lupus syndrome has not previously been reported in association with significant thrombocytopenia. The clinical severity of this patient's presentation, suggesting an aleukemic leukemia, and its complete remission after cessation of procainamide administration occasional this report.
JAMA 1976 Nov 29
PMID:Severe transient pancytopenia associated with procainamide ingestion. 103 16

Prolongation of partial thromboplastin time was noted in patients with acquired immunodeficiency syndrome (AIDS) who were admitted to the hospital for diagnosis of opportunistic infection. As biopsy procedures were often indicated, detailed investigation of the abnormal coagulation study was performed in four patients. Results confirmed the presence of a lupus anticoagulant. Partial thromboplastin times of 34 consecutive subsequent patients hospitalized with the diagnosis of AIDS-associated opportunistic infection were recorded; prolongation was noted in 24 of these. None of these 38 patients exhibited clinical evidence of bleeding. One patient had a confirmed thrombotic episode. Prolonged partial thromboplastin time is a common finding in hospitalized patients with AIDS and opportunistic infection. If no clinical history of unusual bleeding is noted, the lupus anticoagulant should be suspected. Many patients with AIDS require invasive procedures for disease management; the lupus anticoagulant, an in vitro phenomenon, should not prevent these studies.
JAMA 1986 Jul 25
PMID:Lupus anticoagulant in the acquired immunodeficiency syndrome. 308 92

The relationship between lupus anticoagulants and antibodies directed against negatively charged phospholipids, as measured by an enzyme-linked immunosorbent assay, was explored in a series of plasma samples from 100 patients with well-characterized lupus anticoagulants. Only 73% of the patients had detectable IgG, IgM antibodies, or both, to one or more of four phospholipids. Of these patients, 29% had IgG-type antibodies only, 56% had both IgG and IgM antibodies, and 15% had IgM antibodies only. Of the 100 patients, 19% had a history of thrombosis, 8% had a history of spontaneous abortion, and 6% had a history of seizure disorder. These complications occurred in the presence (80%) and absence (20%) of detectable antiphospholipid antibodies. Drug-related antibodies were observed in 34 patients; of these, 71% had detectable anti-phospholipid antibodies and 24% had a history of thrombosis. There were ten patients with lupus anticoagulants associated with infections; none of these patients had a history of thrombosis. The results indicate that antiphospholipid antibodies are not present in all patients with lupus anticoagulants, that the presence of antiphospholipid antibodies in patients with lupus anticoagulants does not increase the risk of thrombosis in these patients, and that drug-related antibodies are associated with an increased risk of thrombosis. Lupus anticoagulants and antiphospholipid antibodies seem to define two distinct but related patient populations, each associated with an increased risk of thrombosis.
JAMA
PMID:The relationship between lupus anticoagulants and antibodies to phospholipid. 312 71

Recent reports strongly suggest an association between a laboratory picture of autoimmunity in the absence of clinical signs and symptoms and the recurrence of spontaneous pregnancy loss. This association seems particularly strong when circulating lupus anticoagulant is present and has therefore been called the circulating lupus anticoagulant syndrome. We present four patients with this syndrome who in addition to the asymptomatic autoimmune laboratory picture were also found to exhibit a distinct IgM gammopathy. In view of earlier reports that implicated IgM in poor pregnancy outcome, particularly in association with systemic lupus erythematosus, it is suggested that all patients with circulating lupus anticoagulant syndrome be evaluated for an IgM gammopathy. A fraction of IgM may be detrimental to development and growth of the normal fetal placental unit and may thus be implicated in repeated early pregnancy loss.
JAMA 1985 Jun 14
PMID:IgM gammopathy and the lupus anticoagulant syndrome in habitual aborters. 392 18

A patient with an eight-year history of systemic lupus erythematosus (SLE) and recent onset of recurrent psychosis died after acute deterioration of cardiopulmonary status and level of consciousness. Autopsy disclosed massive pulmonary hemorrhage and unsuspected fat emboli in the lungs, kidney, and brain. This article discusses the significance of systemic fat embolism in SLE, with reference to corticosteroid therapy, fatal pulmonary hemorrhage, and lupus psychosis.
JAMA 1983 Nov 18
PMID:Fatal pulmonary and cerebral fat embolism in systemic lupus erythematosus. 663 68

Fourteen male patients examined for a prolonged partial thromboplastin time were found to have the lupus anticoagulant. In contrast to previous reports, there was no increased incidence of false-positive results of serological tests for syphilis. In only two patients was systemic lupus erythematosus confirmed, although two additional patients had a positive result of a test for antinuclear antibody. Other clinical diagnoses included peripheral vascular disease, cardiac disease, pulmonary disease, and schizophrenia. Prothrombin times were distinctly abnormal in only two patients. Bleeding was rarely encountered in these patients, including ten who underwent surgical procedures or some type of hemostatic challenge. Thrombocytopenia was not associated with bleeding but was present in two patients who had thrombotic events.
JAMA 1982 Nov 19
PMID:The lupus anticoagulant in 14 male patients. 681 13

A 25-year-old man with renal failure secondary to systemic lupus erythematosus (SLE) received a kidney from his identical twin five years after onset of the first twin's symptoms of lupus. Both continue to do well. To our knowledge, there are no other reports of kidney transplantation in monozygotic twins discordant for SLE.
JAMA 1981 Jan 02
PMID:Kidney transplantation in monozygotic twins discordant for lupus. 700 Oct 81


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