Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0409974 (lupus)
 22,386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

T cell-specific adapter protein is a relatively recently described signaling adapter molecule expressed predominantly in T cells and NK cells. Studies in mouse and man have indicated that reduced expression of TSAd in T cells may predispose toward the development of autoimmune disease. In lupus-prone TSAd-deficient mice the development of autoimmunity is associated with an impaired T cell death response to antigens in vivo. Probably, this impaired death response is consequent to reduced T cell antigen receptor (TCR)-induced synthesis of the interleukin-2 (IL-2) cytokine in TSAd-deficient T cells. TSAd appears to contribute to IL-2 synthesis at multiple different levels acting in both the nucleus and cytoplasm of T cells. Recent advances relating to the role of TSAd in T cell signal transduction and as a regulator of autoimmune responses are discussed.
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PMID:The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man. 1575 54