Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0406810 (
NAME
)
13,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Improving the dysfunction of endothelial progenitor cell (EPCs) in patients with diabetes mellitus is important for preventing vascular complication.
Vaspin
, an adipocytokine, has the anti-atherogenic properties rely on its positive effect on nitric oxide (NO) bioavailability. We hypothesis that
vaspin
may ameliorate high glucose induced dysfunction of EPCs. In rat bone marrow derived EPCs, glucose treatment results in a decrease in the proliferation and migration capacity in a dose dependent manner. These detrimental effects can be alleviated by
vaspin
. Furthermore,
vaspin
increased the production of NO and the effect of
vaspin
on EPCs can be diminished partly by the eNOS inhibitor (L-
NAME
). We assessed total eNOS protein expression and Ser(1177)-phospho-eNOS expression and found that
vaspin
not only induced eNOS protein expression but also up regulate the eNOS activation. Subsequently, we investigated protein kinase B (Akt) activation in the presence and absence of phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor (LY-2940002).
Vaspin
increased total Akt and Ser(473)-phospho-Akt expression and these effects can be blocked by LY-2940002. The results of our study indicate a novel effect of
vaspin
to regulate eNOS expression and function in EPCs via a PI3K/Akt/eNOS pathway;
vaspin
may have a protective effect in patients with diabetes to prevent the occurrence of vascular complication.
...
PMID:Vaspin alleviates dysfunction of endothelial progenitor cells induced by high glucose via PI3K/Akt/eNOS pathway. 2575 37
