Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0406810 (NAME)
 13,345 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The anticonvulsant drug Diazepam (DIA-2 mg/kg b. wt), the nitric oxide (NO) donor L-Arginine (L-Arg-2000 mg/kg b. wt) and the putative nitric oxide synthase (NOS) inhibitor N(G)-Nitro-L-Arginine methyl ester (L-NAME-50 mg/kg b. wt) were used to determine the role of endogenous NO on convulsions induced by picrotoxin (PCT-5 mg/kg b. wt) in rats. Rats given a convulsant dose of PCT (5 mg/kg b. wt) had convulsion and it suppresses the NOS activity and NO concentration in brain regions. The anticonvulsant L-Arg alone significantly increases the NO concentration and NOS activity in brain regions, but not diazepam. Whereas DIA, along with L-Arg, enhances the NO and NOS activity when compared to L-Arg alone. The combination of both OIA and L-Arg completely suppressed the convulsions. L-NAME alone had no effect to produce convulsions but it completely decreased NO concentration and NOS activity and potentiated the PCT convulsions. This was reverted by pre- and post treatment of DIA plus L-Arg indicating, the increased NO concentration and NOS activity in brain regions suppresses convulsions.
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PMID:Involvement of nitric oxide and nitric oxide synthase activity in anticonvulsive action. 1035 70

The distal dural ring plane (DDRP) separates the intradural from the extradural paraclinoid internal carotid artery. The purpose of this study was to evaluate its position with MR imaging. The protocol used a T2-weighted sequence in two orthogonal planes: diaphragmatic (DIA-P) and carotid (CAR-P). The DDRP passes through four anatomoradiological reference points (RefP). We developed on a cadaveric model a correlation method supported by correlation lines and angles (CA) projecting the RefP toward the DDRP. RefP were correlated to the DDRP in 65-84% of cases in the DIA-P and 60-76% of cases in the CAR-P. CA were identified and correlated to the DDRP, respectively, in 87% and 60% of cases in the DIA-P, and 60% and 51% of cases in the CAR-P (failure often related to a lack of visibility of just one RefP). A higher tissular contrast in living subjects allowed the identification of CA in 90% and 80% of cases, respectively, in the DIA-P and the CAR-P. We propose that CA, when identified, should be considered as an approximation of the inferior radiological limit of the DDRP curve. In difficult angiographical cases, this MRI protocol could help to locate paraclinoid aneurysms on both sides of the cavernous sinus roof.
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PMID:MRI location of the distal dural ring plane: anatomoradiological study and application to paraclinoid carotid artery aneurysms. 1613 25