Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0406810 (
NAME
)
13,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
During Trypanosoma cruzi infection the trans-
sialidase
superfamily stimulates the development of a large population of CD4 T lymphocytes that produces IFNgamma. These CD4 T cells fail to proliferate when stimulated in vitro. Why they fail to proliferate remains unclear. Nitric oxide is a critical component of the host immune response against T. cruzi, and to determine if NO inhibits trans-
sialidase
superfamily-specific proliferative responses, mice were fed either N(G)-nitro-L-arginine methylester (L-
NAME
), an inhibitor of inducible nitric oxide synthase (iNOS), or N(G)-nitro-D-arginine methyl ester (D-
NAME
), an inactive analog of L-
NAME
. The L-
NAME
-fed mice had increased parasitemia and mortality compared to the D-
NAME
-fed mice. Following stimulation with a T. cruzi trans-
sialidase
superfamily protein, splenocytes from both groups of mice failed to proliferate but continued to make similar amounts of IFNgamma, suggesting that the development of the trans-
sialidase
superfamily-specific CD4 response was not affected by iNOS inhibition. In addition, IL-2 receptor (IL-2R) expression was increased on T cells isolated from L-
NAME
-fed mice. These data suggest that during T. cruzi infection NO causes downregulation of IL-2R expression, but does not cause inhibition of trans-
sialidase
superfamily-specific CD4 T cell proliferation. Rather, the trans-
sialidase
superfamily proliferation may be inhibited by epitope variation.
...
PMID:Trypanosoma cruzi: the effect of nitric oxide synthesis inhibition on the CD4 T cell response to the trans-sialidase superfamily. 1067 44
