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Query: UMLS:C0406810 (
NAME
)
13,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In preliminary studies, human subjects complained of
drowsiness
after aerosolization of NG-nitro-L-arginine methyl ester (L-
NAME
) into the nasal passages. We compared the effects of a nasal aerosol of L-
NAME
(0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-
NAME
decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-
NAME
on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-
NAME
to the nasal passages induces daytime
sleepiness
.
...
PMID:Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence. 1050 24
The physiologic function of nasal nitric oxide (NO) release is unknown. In prior experiments, topical NG-nitro-L-arginine methyl ester (L-
NAME
) on nasal mucosa reduced exhaled nasal NO output and caused daytime
sleepiness
. We hypothesized that nasal NO output is reduced at night during the sleep period. We measured exhaled nasal NO concentration and minute ventilation and calculated nasal NO output in humans over 24 h. Daytime awake NO output was greater than NO output at night during sleep or transient wakefulness. Exhaled NO concentration decreased during sleep along with minute ventilation. A daytime voluntary reduction in minute ventilation also decreased nasal NO output but exhaled NO concentration increased. Nasal NO output was not changed by body position. We conclude that exhaled nasal NO output is decreased at night due to decreased mass flow of NO into nasal air in addition to decreased minute ventilation. Our findings suggest a role of nasal NO in sleep or in the physiologic processes accompanying sleep.
...
PMID:Exhaled nasal nitric oxide output is reduced in humans at night during the sleep period. 1697 30
