Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0406810 (
NAME
)
13,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hematopoietic stem cells (HSCs) reside and are maintained in specialized microenvironments within the bone marrow known as niches, which are comprised of various cell types. Among them, leptin receptor (LepR)-expressing CXC chemokine ligand 12 (CXCL12)-abundant reticular (
CAR
) cells are known to create a niche for HSCs and at the same time to give rise to osteoblasts. These two functions of
CAR
/LepR
+
cells appear to be tightly but inversely regulated to ensure adequate physical space for HSCs. However, how osteogenesis is prevented in
CAR
cells to maintain spaces available for HSCs and hematopoiesis remains unclear. In this issue of
Genes & Development
, Seike and colleagues (pp. 359-372) report that the transcription factor
early B-cell factor
(
Ebf3
) is preferentially expressed by
CAR
/LepR
+
cells and inhibits
CAR
cell differentiation into osteoblasts while at the same time maintaining self-renewal of
CAR
/LepR
+
cells. Using conditional knockout and retroviral systems, the investigators show that loss of
Ebf3
in
CAR
cells impairs HSC numbers and leads to osteosclerosis. This study provides novel insights into transcriptional requirements for
CAR
cell bone formation by identifying Ebf3 as a niche factor secreted from
CAR
/Lepr
+
cells that regulates the interplay between osteogenesis and hematopoiesis.
...
PMID:A bone marrow niche-derived molecular switch between osteogenesis and hematopoiesis. 2956 84
