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Query: UMLS:C0406810 (
NAME
)
13,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Investigations indicate that the induction of long-term potentiation (LTP) may be mediated by postsynaptic N-methyl-D-aspartate (NMDA) receptors and that the maintenance of LTP may be initiated by nitric oxide (NO), a retrograde messenger carrying signals backward from the postsynaptic to the presynaptic neuron. The present study compared amnestic effects of dizocilpine maleate (MK-801), an NMDA receptor antagonist, and nitro-L-arginine-methyl-ester (L-
NAME
) and N-nitro-L-arginine (L-NOARG), nitric oxide (NO) inhibitors, in goldfish, using active-avoidance conditioning as the learning paradigm. The results showed that MK-801 and NO inhibitors produced
anterograde amnesia
at doses that did not impair performance processes necessary for learning to occur. Furthermore, MK-801 did not produce retrograde amnesia, whereas L-
NAME
did, suggesting that MK-801 impaired learning whereas NO inhibitors impaired memory consolidation and possibly also learning.
...
PMID:Comparison of the amnestic effects of NMDA receptor antagonist MK-801 and nitric oxide synthase inhibitors: L-NAME and L-NOARG in goldfish. 973 95
Our previous study with N-methyl-D-aspartate (NMDA) receptor antagonist D-AP5 suggested that NMDA receptors were involved in learning but not memory consolidation of avoidance conditioning. The present study investigated whether nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were involved in memory consolidation but not learning of avoidance conditioning in goldfish. Experiments 1 to 3 investigated amnestic and performance effects of NO inhibitor L-
NAME
and cGMP inhibitor LY-83583. Experiment 4 investigated whether posttraining intratelencephalic injection of NO donor SNAP ameliorated anterograde amnestic effects of pretraining NO inhibitor L-
NAME
. The results showed that L-
NAME
and LY-83583 produced significant anterograde and retrograde amnesia at doses that did not impair performance processes, and the drugs produced more severe retrograde than
anterograde amnesia
. Furthermore, posttraining SNAP significantly ameliorated anterograde amnestic effects of pretraining L-
NAME
. Thus, our previous results with D-AP5 and current results with L-
NAME
and LY-83583 together suggest that the NMDA receptors are involved in learning or the process that is completed during training, whereas the NO and cGMP are involved in memory consolidation or the process that is normally completed sometime following the learning experience.
...
PMID:The role of telencephalic NO and cGMP in avoidance conditioning in goldfish (Carassius auratus). 1948 68
