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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Maximum active stress and contractile protein contents of the dilated ureter were determined using the chronically obstructed rabbit ureter. Active length-tension curve was demonstrated for tissue strips obtained from normal and dilated ureters. In the normal ureter, maximum active stress of the strips was 10.4 +/- 2.04 X 10(4) dyne/cm.2 while the myosin and actin contents in the tissue were 6.05 +/- 0.44 and 15.46 +/- 1.96 mg./gm. tissue, respectively. Maximum active stress of the obstructed ureter varied from 5.1 X 10(4) to 19.0 X 10(4) dyne/cm.2 The amount of contractile protein in the obstructed ureter varied from 0.57 to 8.07 mg./gm. tissue for myosin and from 8.16 to 22.9 mg./gm. tissue for actin. For various degrees of ureteral dilatation, the active stress and contractile protein content showed similar changes. A significant correlation was demonstrated between maximum active stress and contractile protein content. The myosin amount was more closely correlated with maximum active stress, indicating that the content of myosin is a means of predicting contractility of the obstructed, dilated ureter.
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PMID:Relationship between maximum active stress and contractile protein contents in the chronically obstructed ureter. 647 Dec 33

Using an SDS-polyacrylamide gel electrophoresis, the contractile protein content of the normal rabbit ureter was compared with that of the dilated ureter. The relative amounts of the actin and myosin were significantly decreased in the dilated ureter.
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PMID:The contents of contractile proteins in the normal and dilated ureter. 663 44

After the basic shape of the mammalian ureter is established, its epithelia mature and a coat of smooth muscle cells differentiate around nascent urothelia. The ureter actively propels tubular fluid from the renal pelvis to the bladder, and this peristalsis, which starts in the fetal period, requires coordinated smooth muscle contraction. Teashirt-3 (Tshz3) is expressed in smooth muscle cell precursors that form the wall of the forming mammalian ureter. The Teashirt gene family was first identified in Drosophila where Teashirt (Tsh) protein acts as a transcription factor directing embryonic anterior-posterior patterning and leg and eye development. In fly embryonic renal tubules, Tsh is expressed in mesodermally derived stellate cells intercalating between principal cells, and a paralogue, tiptop, is expressed in forming tubules. Teashirt is a component of several gene networks in flies and it is notable that similar networks control mammalian renal tract development. Null mutation of Tshz3 in mice leads to failure of functional muscularization in the top of the ureter and this is followed by congenital hydronephrosis. A signaling pathway can be envisaged, starting with sonic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth muscle cell differentiation, with Tshz3 downstream of bone morphogenetic protein 4 and upstream of myocardin and smooth muscle cell contractile protein synthesis. The phenotype of Tshz3 mutant mice resembles that of human congenital pelviureteric junction obstruction, and we suggest these individuals may have mutations of genes encoding molecules in the differentiation pathway mediated by Tshz3.
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PMID:Ureter myogenesis: putting Teashirt into context. 1992 88