Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0403608 (
ureter
)
9,655
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
While the pathogenic mechanisms responsible for calcium nephrolithiasis remain unknown, the influence of
heparan sulphate proteoglycan
(
HSPG
) on disease progression of other diseases, such as polycystic kidneys and diabetic glomerulosclerosis, makes it an important candidate for the study of stone formation. Using the indirect immunofluorescence assay and image analysis, we were able to quantify and visualize the loss of
HSPG
localized in the basement membrane of the glomerulus and the mucosa of
ureter
or renal pelvis in patients with recurrent calcium nephrolithiasis as compared to normal subjects. However, no significant change in
HSPG
was observed in the basement membrane of the tubular epithelium. The decreased
HSPG
in the glomerulus may reflect the potentially disrupted anion/neutral barrier for glomerular filtration, which would encourage the accumulation of stone solutes. The drop in
HSPG
staining intensity in the basement membrane of the mucosa of
ureter
/renal pelvis may suggest the tendency of adhesion of crystal to urothelial surfaces. Based on these immunological data, it appears that
HSPG
plays a modulatory role in the pathogenesis of this disease.
...
PMID:Determination of heparan sulphate in kidney tissues of patients with calcium nephrolithiasis. 883 92
