Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Surgical excision is the usually recommended treatment of Fibromatosis in children. However the invading nature of this tumor is responsible for recurrences leading to mutilating surgery and eventually to death despite the histologically benign appearance. We observed two cases of decrease under lengthy chemotherapy. In the first case, a 4-year-old boy with a huge abdominal wall tumor had two biopsies leading to the diagnosis of fibromatosis. The tumor measured 15 x 14 x 10 cm, and compressed the right ureter when chemotherapy was started. Actinomycin 1,500 microgram/m2 at Day 1 and vincristine 1.5 mg/m2 at Day 1 and Day 8. This courses were repeated every four weeks. Tumor decreased slowly but constantly. After 17 months it measured only 5 cm in diameter. The biopsy confirmed the nonprogressive nature of the residual fibromatosis. In the second case, a 12-year-old boy had a tumor of the left anterior thoracic wall. The histologic study diagnosed a fibromatosis. Two courses of IVA (ifosfamide, vincristine, actinomycin), did not lead to any decrease. A wide excision was achieved but left invaded edges. Then the child was treated by actinomycin 750 microgram/m2 at Day 1 and vincristine 1.5 mg/m2 at Day 1 and Day 8, one course every four weeks during ten months. At this time biopsies revealed a scar without progressive fibromatosis. This two cases show the interest of a chemotherapy in extensive fibromatosis. A mild treatment but for a long time seems to succeed where more intensive courses have failed.
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PMID:[Fibromatosis in children: regression with prolonged chemotherapy. Apropos of 2 cases]. 246 38

Severance of the ureter beyond the renal papilla causes a fall in urinary osmolality, which suggests that exchange of water or solute between urine and renal parenchyma normally occurs in the intact renal pelvis. We examined water and solute flux in the renal pelvis with micropuncture and microcatheterization techniques. Four groups of antidiuretic rats were studied. Group I (n = 17) underwent micropuncture through the intact contracting ureter. Urine samples were obtained at the papillary tip, and in the pelvis beside the base of the extrarenal papilla. Urinary osmolality at the base, 880 +/- 97 mosmol/kg H2O (mean +/- SE), was less than that at the tip, 1,425 +/- 104 mosmol/kg H2O (P less than 0.005). In group II (n = 24), samples were analyzed for inulin and osmolality. In 15 rats (group IIA), comparison was made between base and tip samples. In the other nine animals (group IIB), comparisons were made among base, tip, and bladder samples and urea was also measured. In group II (A and B combined) urine-to-plasma (U/P) osmolality was lower at the base, 4.31 +/- 0.27, than at the tip, 6.08 +/- 0.23 (P less than 0.001), and U/P inulin was lower at the base, 192 +/- 25, than at the tip, 306 +/- 16 (P less than 0.001). In group IIB, the bladder urine had a lower U/P osmolality, 5.27 +/- 0.25, than the tip, 6.01 +/- 0.31 (P less than 0.02). The U/P urea was 59 +/- 10.6 (base), 98 +/- 9.4 (tip) (base vs. tip, P less than 0.05), and 81 +/- 6.5 (bladder, P less than 0.005, compared with tip). In group III (n = 8), samples were obtained by microcatheter from the fornices, the deepest intrarenal extensions of the pelvis, and compared with samples at the tip. Urinary osmolality was lower in the fornix, 646 +/- 106 mosmol/kg H2O, than at the tip, 1,296 +/- 99 mosmol/kg H2O (P less than 0.001). Similarly, U/P inulin was lower in the fornix, 48 +/- 14, than at the tip, 128 +/- 12 (P less than 0.001). The lower U/P inulin in the pelvic urine is the result of either the addition of fluid to the pelvis, or the backleak of inulin across the epithelium lining the pelvis. To verify that the pelvic epithelium was impermeable to inulin, in group IVA (n = 4) the left renal pelvis was superfused with a solution of chemical inulin. Cumulative absorption of inulin from the left kidney was 0.15 +/- 0.08% of that superfused. Using [14C]inulin in group IVB (n= 3), similar results were obtained (0.05 +/- 0.02%). These findings indicate that in the renal pelvis, fluid is added to urine after it emerges from the collecting ducts. We suggest that reflux of hyperosmotic urine over the renal papilla creates a transepithelial gradient for the flux of water into the pelvis. A model that incorporates diffusive and convective forces for water and solute transport is proposed to account for these findings.
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PMID:Examination of transepithelial exchange of water and solute in the rat renal pelvis. 650 75