Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to assess the existence of mechanisms regulating the intensity and duration of action of calcitonin gene-related peptide (CGRP), the main candidate inhibitory transmitter released from capsaicin-sensitive afferents in the guinea-pig ureter. In a first series of experiments, performed in capsaicin-pretreated ureters, exogenously administered human alpha CGRP (h alpha CGRP) produced inhibition of contractions of the guinea-pig isolated ureter evoked by direct electrical stimulation of smooth muscle. The intensity and duration of the inhibitory effect of h alpha CGRP were potentiated by the inhibitor of neutral endopeptidase, thiorphan, while captopril and bestatin were without effect. In a second series of experiments, background motility of the guinea-pig ureter was evoked by administration of endothelin-1 (ET-1): electrical stimulation of intramural nerves produced a transient suppression of the ET-1-evoked contractions, ascribable to release of endogenous CGRP. Thiorphan enhanced the inhibitory effect produced by endogenous CGRP, while bestatin and captopril were without effect. These findings demonstrate that a thiorphan-sensitive mechanism, presumably neutral endopeptidase, regulates the intensity and duration of the inhibitory activity of both exogenous and endogenous CGRP in the guinea-pig ureter. The existence of a mechanisms for inactivation of the released peptide is consistent with the proposed role of CGRP as inhibitory neurotransmitter in this preparation.
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PMID:A thiorphan-sensitive mechanism regulates the action of both exogenous and endogenous calcitonin gene-related peptide (CGRP) in the guinea-pig ureter. 752 18