Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the urological field, one of the most effective drugs is doxorubicin. A cooperative phase II study on pirarubicin (THP), a new anthracycline with less cardiotoxicity than doxorubicin, was performed in 14 institutions for treating urological tumors. THP was administered intravenously 3 or more times (as one course, 30-40 mg/m2 once a week, every 3 weeks or 20 mg/m2 2 consecutive days a week every 3 weeks). Fifty-four of the 63 patients included in this study were evaluable. An overall efficacy rate was 18.5% (10/54), consisting of transitional cell carcinoma 24.3% (9/37; bladder cancer 6/27 (22.2%), tumors of the renal pelvis and ureter 3/10 (30.0%), and prostatic cancer 1/15 (6.7%). Adverse effects were mostly slight especially alopecia (15.9%, WHO grade 1:7 patients and grade 2:3 patients), and there was no problem attributable to cardiotoxicity of THP. Leukocytopenia was seen for 65.1% (grade 1:14 patients, grade 2:13 patients, grade 3:13 patients, and grade 4:1 patients). The nadir was observed about 2 weeks later and it took about 2 weeks for the recovery. Thus, it can be concluded that the usefulness of THP in treating urological tumors is comparable to or better than that reported for doxorubicin. Based on the above results, a combination regimen including THP has been investigated in Japan.
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PMID:Cooperative study of pirarubicin against urological cancers and future direction of its combination use. The Clinical Study Group of THP for Urological Malignant Tumors. 229 54

By utilizing enzymic immunoassay, in a total of 161 cases of urologic tumors, Tamm-Horsfall Protein Coating Cells (THPC) could be found uniquely in the urines of renal tumors, whereas was absent in those of normal control as well as in the urines of transitional cell carcinomas of pelvis, ureter and bladder. Renal cell carcinoma predominated over in the THPC positive cases, among which granular cell carcinoma demonstrated a higher positive rate than that of clear cell type, 40% versus 15%. THP antigen could be found in the 66.6% frozen sections of renal cell carcinoma and the THP concentration in urine were also higher. Therefore, the detection of THP coating cells in urine of urologic neoplasm may be useful in evaluating the renal origin of the exfoliated tumor cells and elevating the screening accuracy of renal cell carcinoma, with no harms to the patients and no special equipment.
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PMID:[An evaluation of urinary Tamm-Horsfall protein coating cell in the diagnosis of urologic neoplasms]. 236 14