Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results of a 99mTc-DTPA study of vesicoureteral reflux in 51 children with recurrent urinary tract infections were compared with those of radiographic micturition cystourethrography. Reflux, shown by either of the two methods, was regarded as an indication of the disorder. Neither method was regarded as a standard reference method. Agreement between the two methods was obtained in 90 of 102 renal units, i.e., ureter and/or renal pelvis (88%). Statistical analysis performed on the remaining 12 cases showed that the two procedures usually gave similar results.
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PMID:Measurement of vesicoureteral reflux with intravenous 99mTc-DTPA compared to radiographic cystography. 61 9

There is one renal disease in which unilateral estimation of GFR is desirable for clinical purposes: chronic pyelonephritis. Considering the possibilities for complications to determine unilateral renal function by ureter catheter just in this group of patients, we tried to estimate unilateral GFR with 66mTc-DTPA after a single injection of 5 mCi i.v. on the basis of blood samples at 90, 110 and 130 min after injection and evaluation of gamma-camera data from 25 to 35 min after administration of the dose. 31 patients were studied. In arenal patients clearance values were 7.5 ml/min (+/- 10.47 ml/min), unilaterally nephrectomized patients showed zero values for the removed kidney. Normal patients had a mean GFR of 107 +/- 17.7 ml/min with a partition between right and left kidney of 54.2 +/- 10 to 52.75 +/- 8.5 ml/min. Patients without urinary tract obstruction and unilateral renal disease had values of 27.1 +/- 11 ml/min for the diseased kidney while the normal kidneys gave a mean value of 59.6 ml/min (+/- 13 ml/min). In the presence of urinary tract obstruction, data could not be correlated to the state of renal function. This shows that unilateral estimation of GFR using 99mTc-DTPA is basically possible, but that it is useless in obstructive kidney disease.
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PMID:Unilateral estimation of glomerular filtration rate with 99mTc-DTPA. 69 96

A patient with a post-traumatic retroperitoneal urinoma is presented. On admission, there was a clinical suspicion of retroperitoneal hematoma and ultrasonography (US) was performed which showed a hypoechoic fluid collection suggesting retroperitoneal hematoma. In order to determine the nature of the fluid, radionuclide angiography and renal scan were performed successively with 99mTc-DTPA. Demonstration of urinary leakage into the mass in the delayed renal scintigraphic images suggested a urinoma. At laparotomy, total transection of the left ureter in the uretero-pelvic region was found and the diagnosis of urinoma was confirmed.
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PMID:The value of 99mTc-DTPA renal scintigraphy in the evaluation of post-traumatic abdominal fluid collection. 138 96

To assess the influence of the ureter on renal washout during 99mTc-DTPA diuresis renography, ureteral images were reviewed in 42 children (median age: 5 mo) referred for hydronephrosis. Sixty-minute acquisitions were obtained in hydrated patients under bladder drainage. Furosemide was injected at 30 min. An abnormal ureter was defined as an intense and continuous image of greater than 10 min. A washout index was determined on renal (KT1/2) and ureteral (UT1/2) curves. Curve patterns corresponding to normal (type I), obstructive (II) and nonobstructive (III) cases were described. Compared with the x-ray data, diuresis renography was highly sensitive (91%) and specific (98%) for detecting any abnormality. Despite an obstructive KT1/2 (greater than 20 min), no patient with an abnormal ureter underwent therapy at the ureteropelvic junction. After surgery at the lower level, hydronephrosis regressed. Our data indicate that abnormal ureter findings at diuresis renography have to be recognized before planning therapy for children with hydronephrosis.
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PMID:Influence of ureteral status on kidney washout during technetium-99m-DTPA diuresis renography in children. 173 Oct 1

A new method for the evaluation of ureteric peristalsis is described. Standard, dynamic renal scintigraphy was carried out using 99Tcm-MAG 3 in 59 patients. Time-activity curves and condensed images over the ureter area were created simultaneously. A six-grade scale (O-V) was chosen for the classification of ureteral function. The results obtained were compared with parameters of renographic curves and other clinical findings. In a group of 13 patients, two different renal radiopharmaceuticals were used: 131I-OIH and 99Tcm-DTPA. The results show that the new method is suitable for the assessment of ureteral disorders, and has some advantages compared with previously described methods. 99Tcm-MAG 3, with a better target-to-background ratio compared to 131I-OIH and 99Tcm-DTPA, is the most suitable radiopharmaceutical for this purpose.
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PMID:A new approach in radionuclide imaging to ureteric peristalsis using 99Tcm-MAG 3 and condensed images. 183 50

A group of 76 patients with urographically proven acute calculus obstruction was studied prospectively using 99mTc-DTPA renography to see if kidneys at risk of irreversible renal damage could be identified. There was a statistically significant relationship between the presence of obstruction on renography and the subsequent requirement for intervention, but not with the degree of obstruction (partial or severe). Stones over 5 mm in size are highly likely to cause obstruction, a drop in relative renal function and require intervention. In all, 14 patients sustained a drop in relative renal function of greater than 7% on renography and 12 of these returned to normal limits when their calculi had been passed or removed. The 2 kidneys whose function remained impaired had fallen below 25% of overall renal function and both patients had received prior treatment for their calculi. No patient who presented de novo suffered any permanent loss of ipsilateral renal function. The results confirm that the criteria for intervention were well founded and emphasise the importance of achieving a stone-free state after primary treatment. Renography is recommended for stones over 5 mm in size, those in the middle and upper ureter and for those patients discharged with a stone in situ.
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PMID:Sequential renography in acute urinary tract obstruction due to stone disease. 200 21

With regard to different paediatric urological diseases nuclear-medical urokinetography using the tracer 99m-Tc-DTPA can identify typical functional patterns. By means of 261 investigations on 240 children, retroperistaltic waves, initial pyeloureteral and the final ureterovesical conus, dysperistaltic waves and interrupting empty strips with lacing, constrictive peristalsis can be shown in comparison with the normal anterograde "stair" pattern. Moreover, UKG as a functional method makes it possible to control the therapeutic success of antibiotics in urinary inflammations, the situation after stone discharges and application of vegetative systemic drugs. In our opinion the operative procedure and the prognosis of megaureters can be assessed. Consequently urokinetography is among the important preoperative investigations in paediatric urology and in the follow-up programme after reconstructive urological operations. Nuclear-medical isotope investigation is without significant risk and yields many diagnostic details. The method can be recommended for functional urological diagnosis in children or teenagers with high frequency of follow-up investigations or in patients with contrast medium allergy. Finally, ureter physiology can be checked in patients subjected to bone scintigraphy. Clinical research is possible via UKG without additional radiation exposure.
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PMID:[Urokinetography in the diagnosis and follow-up of obstructive uropathy in children]. 219 67

There is no simple analytical test. Radionuclide diuretic renography (RDR), being a dynamic imaging study reflecting the function of the kidney and the urodynamics of the urinary tracts, has the potential to predict the outcome of surgery in obstructive uropathy. In 12 sheep, we occluded one ureter for a maximum of seven weeks and followed up for a maxim of five weeks after release of occlusion. Repeated Tc-99m DTPA diuretic renography studies were performed and the results were correlated with the duration of complete ureteric occlusion. The renal uptake percentage and the extraction slope of the time activity curve (TAC) showed progressive and steady decrease over the period of the occlusion. By the fifth week there was very low uptake (less than 18%) and the TAC was almost flat, suggestive of severe nephropathy. The parenchymal transit time index (PTTI) showed immediate rise after occlusion but with no progressive increase in its value. By the fifth week it dropped down to normal. After release, the recovery of function showed good correlation with the renal uptake percentage and extraction slope of TAC before release of occlusion. Therefore both these parameters, rather than PTTI, can be used to predict the outcome of surgery before the release of complete obstruction of the ureter.
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PMID:The predictive value of Tc-99m DTPA renography in obstructive uropathy using animal model. 228 20

31 patients of ureteral duplication were selected when one moiety of the duplex system was poorly visualised with either IVU or DTPA studies. Both ultrasound and IVU were performed in all cases. DTPA scans were performed in 17 cases and MCUs in 26 cases. The cases were divided into 2 groups. Group 1 (28 patients), with hydronephrosis and hydroureter, was further subdivided into 1 A (18 patients) where the ureter terminated in an ureterocoele and 1 B (10 patients) where the ureter was ectopic. Group 2 (3 patients) were cases where the non-functioning moiety was hypoplastic or dysplastic and was drained by a small or normal size ureter. The diagnostic value of IVU, Ultrasound, DTPA scan and MCU was reviewed in each group.
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PMID:Imaging of ureteral duplication with a non-functioning component. 235 95

Forty patients with acute onset renal colic were studied using technetium-99m DTPA renal scintigraphy. Thirty-two were found to have varying degrees of obstruction. In the obstructed group the level was determined by the scan alone in 24 of 32 cases (75%). When the analysis included an abdominal radiograph, the level of obstruction was ascertained in 29 of 32 cases (91%). A delayed nephrogram, as evidenced by an "empty renal pelvis sign" at 5 minutes, was observed in all but one of the cases of obstruction (97%). Delayed clearance of activity from the pyelocalyceal system or ureter was also seen in 97%. In all cases of obstruction either one or both of these signs were observed. However, delayed clearance was found to be a nonspecific finding and was noted in 25% of nonobstructed cases. The finding of the "empty renal pelvis sign" at 5 minutes was found to be specific and was not seen in the nonobstructed group. The authors conclude that radionuclide renal scanning is an effective method for evaluating selected patients with suspected renal colic.
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PMID:Nuclear scintigraphy in the evaluation of renal colic. 240 4


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