Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 30-year-old female was admitted to our hospital complaining of hematuria and right flank pain in September, 1987. She had been diagnosed idiopathic thrombocytopenic purpura in 1980, and had similar symptoms before. Hematoma in the right ureter was demonstrated by retrograde pyelography and CT-scanning, and these symptoms improved within one month. Each activity of plasma clotting factors was within normal limits. Enzymatic studies of the urine revealed low values of plasmin-, urokinase-, and kallikrein-like activities in both excerbation and remission. These hemorrhagic tendencies might have been the result of marked thrombocytopenia: After bleeding into the urinary tracts began, the bleeding would tend to form hematoma because of elevated clotting activity; then hematoma would grow due to decreased urine fibrinolytic activities. This suggested that a decline of fibrinolysis in urine might have a promoting effect on the process of hematoma formation.
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PMID:[Possible mechanisms of hematoma formation in the urinary tracts in a patient with idiopathic thrombocytopenic purpura]. 224 28

Fibrinogen Fg-D, obtained by plasmin-induced cleavage of fibrinogen, was separated and purified by ion exchange chromatography. The in vivo behavior was studied by administering 2 mg of (125)I-labeled Fg-D intravenously into each of 3 normal, 3 partially hepatectomized, 3 reticuloendothelial system (RES) blockaded, 4 nephrectomized and 2 ureter ligated rabbits. The plasma clearance in normal rabbits showed two components: 66.0 +/- 6.0% was cleared with a t(1/2) of 0.9 +/- 0.2 hours and 32.3 +/- 5.3% cleared with a t(1/2) of 3.6 +/- 0.3 hours. In both the partially hepatectomized and RES-blockaded groups, the clearance patterns were similar to those observed in the normal animals. In contrast, in the nephrectomized group, while the t(1/2) of the first component was similar to that in the normal group, the second component had a longer t(1/2) (6.0 +/- 1.0 hours) than the other groups. In the animals with both ureters occluded, the t(1/2)'s were similar to the normal animals. Measurements of urinary radioactivity suggested that complete in vivo catabolism had occurred. In vivo subfragments of Fg-D could not be detected in the plasma. Neither Fg-D nor subfragments were found in the urine. These results indicate that Fg-D is rapidly cleared from the plasma, that in vivo subfragmentation does not occur, and that the kidneys are important in the catabolism of a portion of Fg-D.
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PMID:In vivo behavior of fibrinogen fragment D in experimental renal, hepatic and reticuloendothelial dysfunction. 471 41

Tissue damage by extracorporeal shock wave lithotripsy (ESWL) is assumed to be attributable to ischemic changes in the treated region surrounding the particular vessel which is first ruptured by shock waves. Such changes cannot take place without being accompanied by acceleration of coagulation and fibrinolysis. In the literature on renal damage by ESWL, no parameters of the coagulation and fibrinolysis of blood were used. The present study was designed to investigate renal damage by shock waves through the quantification of sequential changes in the following parameters between before and after ESWL: thrombin antithrombin III complex (TAT), alpha 2-plasmin inhibitor-plasmin complex (PIC), fibrin and fibrinogen degradation products (FDP) and D-dimer (D-D). In ESWL for renal stones, a significant acceleration of TAT occurred on the 1st postoperative day, followed by acceleration of PIC on the 3rd postoperative day. A transient acceleration was observed for FDP and D-D after operation. The levels of these parameters, however, returned to normal by the 1st postoperative week. In ESWL for ureteral stones, unlike for renal stones, none of the parameters showed statistically significant acceleration. In the construction of percutaneous nephrostomy (PNS) cases for ureteral stones before ESWL, none of the parameters showed significant acceleration either. Changes in these parameters of coagulation and fibrinolysis due to ESWL for renal stones were greater than those of construction of PNS or ESWL for ureteral stones. The reason for the difference of the alteration in these parameters between renal stones and ureteral stones were more abundant vessels in the kidney than the ureter. All these changes in the parameters, however, disappeared within almost 1 week.
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PMID:Studies on changes in parameters of the coagulation and fibrinolysis in association with extracorporeal shock wave lithotripsy. 846 83