Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Self-expanding metallic stents were inserted into the ureters of two female patients (29 and 46 years old) with malignant ureteric stenosis, in the first patient caused by metastases of a malignant melanoma, in the second by retroperitoneal lymph-node metastases from a colon carcinoma. In the first patient the stent was introduced antegrade into the left ureter via a nephrostomy after balloon dilatation of the stenotic segment. She was subsequently without symptoms, but six weeks later the ureter got kinked just above the bladder due to continued tumour growth against the stent. After insertion of a silicon splint she had no further symptoms referrable to the kidneys until she died two months later. In the other patient in whom both ureters were obstructed they could not be catheterized percutaneously. Stents were, therefore, introduced transurethrally after previous balloon dilatation of the stenoses. Obstruction occurred in the right ureter three days after the procedure due to mucosal oedema, but it was controlled by anti-inflammatory drugs. Hydronephrosis developed again six months later, caused by circumscribed incrustations in parts of the the stent not covered by mucosa. Silicon splints were placed bilaterally and the patient has so far been free of symptoms for two months.
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PMID:[Self-expanding metallic stents in malignant ureteral stenosis]. 201 64

We report here on a patient with recurrent sigmoid colon carcinoma. Postmortem examination revealed a fist-sized tumor in the retroperitoneum, invasive to the left ureter obstructing its lumen causing hydronephrosis of the ipsilateral kidney. Histological examination of the kidney showed multiple foci of adenocarcinoma cells on the pelvic surface. Invasion into the underlying tissue was not observed, and there was no tumor in the submucosal tissue of the pelvis or in the parenchyma of the left kidney. Cancer cells on the renal pelvic mucosa showed strong immunoreactivities for CEA and CA 19-9. These findings suggest that the tumor foci in the pelvis are formed by the intraluminal implantation of colon cancer cells detached from the ureteric metastasis. Our case presents the possibility of the implantation of carcinoma cells in the human urinary tract.
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PMID:Implantation of colon cancer cells onto renal pelvic mucosa. A case report. 292 Jan 5

The development of colon carcinoma after ureterosigmoidostomy has not received adequate attention in the radiologic literature. Two patients who had ureterosigmoidostomy and subsequently developed tumors are described. The third case is a patient with a ureterosigmoidostomy and a ureterocele that simulated the appearance of carcinoma in the sigmoid colon. This is the first report of this entity. Ureterosigmoidostomy patients need frequent follow-up studies since their incidence of carcinoma is significant. The use of barium to study the colon in this group of patients is controversial. Barium can potentially reflux into the kidney with fecal material, which can lead to fibrosis and impaired renal function. However, barium reflux up the ureter is usually of no significance except on those rare occasions when intrarenal reflux occurs and inflammatory changes may develop. The diagnosis of tumors in these patients, diagnostic pitfalls, and controversy regarding use of barium enemas in following these patients are discussed.
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PMID:Ureterosigmoidostomy: the development of tumors, diagnosis, and pitfalls. 660 34

This report presents three cases of colon tumors which developed after an ureterosigmoidostomy. In a checkup, four years after the operation, an inflamed polyp was found in one patient. The second patient developed an adenoma in the section of the colon where the ureter had been implanted. The last patient died of adenocarcinoma of the colon 26 years after her operation. Possible reasons for the development of the tumors, specifically the cancerous ones, are discussed. The risk of developing colon carcinoma is 500 times higher in those who have had an ureterosigmoidostomy than in healthy people. In the case that the ureters are rediverted the section of the colon where they were previously attached must be excised; since there is a strong possibility of cancerous development. To detect the early development of tumors in the colon, we suggest that patients have their stool tested for blood at regular intervals starting 3 years post operatively. If no problems arise barium enema and coloscopy are recommended every five years.
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PMID:[Tumors of the colon following ureterosigmoidostomy]. 668 45

A 43-year-old woman with recurrent colon carcinoma presented with bilateral pelvioureteral obstruction. After a 6F ureteral catheter had been in place for 4 days the left ureter was perforated near the ureteropelvic junction, while an attempt was made to insert a 7F Cook indwelling pigtail ureteral stent. The errant stent was allowed to remain in its extraureteral locale until urinary drainage was established. To our surprise the stent had been placed into the renal vein, after exiting the ureter 2 cm. inferiorly. There was excellent tamponade. When the large stent was removed severe bleeding ensued that was controlled by ligatures. Methods to prevent perforation are discussed. Should perforation of these stents occur in the proximal ureter or renal pelvis it would seem judicious to leave these in place rather than perform any further endoscopic manipulation before surgical inspection.
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PMID:Ureteral and renal vein perforation with placement into the renal vein as a complication of the pigtail ureteral stent. 743 9

A case of an aggressive desmoid tumor in a patient with familial adenomatous polyposis is described. The lesion rapidlyenlarged with compression of adjacent structures including the ureter and small bowel, and the patient died because of small bowel perforation and hydronephrosis 3 years after detection of small desmoid tumors at the time of a prophylactic coloproctectomy for a colon carcinoma. Immunohistochemically, proliferating cell nuclear antigen (PCNA), p21WAF1/CIP1 and cathepsin D indices, but not the bcl-2 index, which were defined as the numbers of immunoreactive tumor cells per 1000 tumor cells, increased in line with tumor progression. The tumor did not show staining for collagen IV, but was characterized by intense staining for basic fibroblast growth factor (bFGF). Accordingly, tumor aggression was related to increases in both cell proliferation and protease activity, as well as an enhanced expression of bFGF. In addition, the desmoid tumor showed deregulation between PCNA and p21WAF1/CIP1 because the normal inverse relation between these two was not apparent.
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PMID:An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings. 1002 64

A 66-year-old man was admitted to our hospital with left flank pain. Drip infusion pyelography (DIP) and abdominal computed tomography (CT) showed urinary extravasation. Magnetic resonance imaging (MRI) and retrograde pyelography (RP) demonstrated stenosis of the ureter. Left nephroureterectomy was performed. Histopathological examination showed poorly differentiated adenocarcinoma, located in the ureteral wall with intact mucosa and adventitia. After the operation, sigmiod colon carcinoma was pointed out by colon fiberscope, and sigmoidectomy was performed.
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PMID:[Spontaneous rupture of the ureter caused by metastatic ureteric tumor: a case report]. 1562 41

Although double J (DJ) ureteral stents are widely used in extrinsic ureteral obstruction, there are few studies using ipsilateral two DJ stents in the same ureter. We report using ipsilateral two ureteral DJ stents in the same ureter in a patient with extrinsic ureteral obstruction due to colon carcinoma.
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PMID:Using two ipsilateral double j ureteral stents for extrinsic ureteral obstruction due to colon carcinoma. 1713 92

The presence of synchronous multiple primary carcinomas, although recognized, remains very uncommon. Their etiopathogeny is unclear. The wide spread of imaging techniques currently facilitates diagnosis of simultaneous tumors. We present the rare case of a signet ring cell colon carcinoma coexisting with a transitional cell carcinoma (TCC) of the ureter, which debuted with symptoms of intestinal obstruction in a 75-year-old male patient, with no prior relevant history. Computed tomography showed signs of a tumor mass on the transverse colon, as well as left hydronephrosis with a tumor in the lower third of the ureter, which prompted for immediate emergency surgery. After the appropriate surgical maneuvers, tissue collected from both tumors underwent usual histological preparation and Hematoxylin-Eosin staining, as well as multiple immunostaining with a complex panel of markers. The patient had a favorable postoperative course and during a six-month follow-up, we did not detect any signs of illness.
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PMID:Synchronous diagnosis of signet ring cell colon carcinoma and transitional carcinoma of the left distal ureter. 2406 15