Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 72 patients with urothelial carcinoma of the renal pelvis or ureter the ploidy, deoxyribonucleic acid (DNA) heterogeneity and counts of cell cycle phases in the tumor were analyzed by means of single cell DNA cytophotometry with the intention of finding new prognostic factors in addition to those already known (stage and grade). Followup ranged from 1 to 8 years. The results of the DNA analyses were related to the tumor categories, histopathological grading of the tumors and clinical course. Malignancy grade 1 tumors showed DNA frequency peaks in the diploid range, while tumors assessed as malignancy grade 2 showed heterogeneous DNA distribution patterns. Malignancy grade 3 tumors exhibited 71% aneuploid and 29% tetraploid DNA values. The proliferation rate of the tumor cells was statistically significantly higher in malignancy grades 2 and 3 than in malignancy grade 1. The prognosis for grade 1 tumors is good, whereas it is unfavorable in the case of grade 3 tumors. For these 2 groups (patients with grades 1 and 3 tumors) DNA ploidy affords no additional prognostic information. Grade 2 tumors, on the other hand, are heterogeneous in respect to DNA ploidy although they exhibit the same histomorphological degree of differentiation. These tumors can be subclassified as aneuploid (biologically aggressive) and diploid or tetraploid (biologically less aggressive) tumors. There was also a positive correlation between T category and DNA ploidy. The cell lines were aneuploid in 38% of the patients with stage T1 tumors, 56% with stage T2 tumors and almost 85% with stage T3, N+ tumors. A significant correlation was found between the results of DNA cytophotometry and the clinical course of the disease. Patients with diploid tumor cell nuclei had no metastases and no local tumor progression for up to 8 years, whereas patients with aneuploid tumor cell nuclei suffered metastasis and local tumor progression within 24 to 36 months. The patients died of the tumor 36 months after primary diagnosis on the average. The determination of DNA ploidy, tumor heterogeneity and tumor cell proliferation by means of DNA cytophotometry affords valuable clues as to prognosis.
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PMID:Transitional cell carcinoma of the renal pelvis and ureter: prognostic relevance of nuclear deoxyribonucleic acid ploidy studied by slide cytometry: an 8-year survival time study. 161 75

A case of carcinoma in situ (CIS) in the right renal pelvis in a 71-year-old women is reported. The patient was admitted because of macroscopic hematuria. Drip infusion pyelography showed a filling defect (coagulum) in the right renal pelvis. Other abnormal findings were not made. Malignancy was suspected by cytology examination in both voiding urine and that obtained by catheter from the right pelvis. A right total nephroureterectomy was performed. Macroscopic abnormal findings were only of the coagulum in the renal pelvis. Pathologic examination showed CIS in the renal pelvis. We studied the features, pattern of recurrence, and prognosis of 19 cases of primary CIS in the upper urinary tract in the Japanese literature. A slight higher frequency was reported for women than for men. When the CIS was in the ureter, abnormal roentgenological findings, such as stenosis, filling defects, or a dilated ureter, were common (77%), contrary to expectation. But when the CIS was in the pelvis, such findings were rare. Urine cytology examination was positive in 95% of the patients. In four of the 19 patients, a recurrence was found. In all four patients, the first recurrence was in the bladder within 2 years of surgery. The kind of recurrent bladder tumors varied with the patients. The prognosis with recurrence was poor. If signs of recurrence were not recognized within 2 years of surgery, the prognosis was good.
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PMID:[Case report of primary carcinoma in situ in upper urinary tract and review of the Japanese literature]. 266 97

60 patients with primary retroperitoneal tumor were reported. Among them, 26 cases were benign and 34 malignant. Abdominal mass was the most frequent presenting symptom (58.3%). The next was abdominal pain. The clinical course varied from 1 day to 22 years. Malignancy was predominant in patients with history less than one year. The size of tumor varied from 3 X 3 X 3 cm to 34 X 24 X 11 cm. Malignancy was more frequent in tumors larger than 10 cm in diameter. The location is decided mainly by displacement and compression of the gastrointestinal tract in barium meal examination and displacement or compression of the kidney or ureter and the presence of hydronephrosis in intravenous pyelography. The final diagnosis can only be established by pathological examination on celiotomy. All 60 patients were operated and the lesion of 43 was resectable. In the 20 with malignant tumor resected, only 8 patients are alive, while all the 26 patients with benign tumor are surviving, though 3 of them had unremovable lesions. The treatment is to resect the tumor as thorough as possible, including the adjacent invaded organs. Recurrence is likely for which resection should be reconsidered if possible. Radiotherapy or chemotherapy should be given to patients with lymphosarcoma, unremovable tumors and residual lesions after resection.
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PMID:[Primary retroperitoneal tumor]. 375 73

The authors report the case of a 49-years-old man with an undifferentiated malignant gonadal stromal tumor of the right testis. Malignancy is confirmed by metastasis in the retroperitoneal lymph nodes. After 6 courses of chemotherapy with Cis-platinum, a retroperitoneal lymphadenectomy was performed and the section of the nodes showed a muscular differentiation of the tumor. This drug regimen did nod induce a complete response and an early recurrence occurs after lymphadenectomy which included the right ureter. The renal function was preserved by the way of a double J indwelling ureteral stent. A total remission was obtained with chemotherapy using Cis-platinum and 5-Fluorouracil, associated with a rapid fraction irradiation for six courses. Total response was assessed by scanner and by a laparotomy for bowel radiation sclerosis.
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PMID:[Malignant tumor of testicular gonadal stroma. Treatment by combined chemotherapy-radiotherapy]. 404 7

Malignant tumors of the ureteral smooth muscle are rare and the prognosis is not clear. This is a report of a patient with primary leiomyosarcoma of the ureter surviving 9 years and 9 months postoperatively without any evidence of recurrence. Malignancy of the ureter was suspected on the basis of angiography and radical nephro-ureterectomy was performed without positive cytology results.
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PMID:Primary leiomyosarcoma of the ureter. 764 46

Malignant neoplasm arising from ileal ureter used for ureteral reconstructive surgery is an exceedingly rare event. Ureteroileoplasty was being performed since the beginning of the last century, but it was described more extensively in literature during the 1950s.1,2 Recurrent urinary infections, chronic renal failure, urolithiasis, anastomotic stricture, metabolic acidosis, and chronic dilation of the graft had been described as late complications of ureteroileoplasty.3,4 Herein, we describe history, imaging and pathologic findings of a small bowel adenocarcinoma arising from ileal ureter in a woman of 78-year-old, subjected to ureteroileoplasty about 40 years earlier.
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PMID:Small Bowel Adenocarcinoma of Ileal Ureter 40 Years After Ureteral Reconstructive Surgery. 3100 45