Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among congenital urethral malformations, posterior urethral valves represent one of the main causes of severe infravesical obstruction in children, the etiology and embryological development of which remains unclear. Posterior urethral valves of types I and III are supposed to be related to either the persistence of connective tissue along the pathway of migration of the Wolffian duct (type I) or a residual part of the endodermal urogenital membrane (type III). A possible reason for supramontane urethral valves (type II) is seen in the persistence of crest-shaped tissue along the ureter's pathway in embryological development to its final site, although there is some doubt as to the existence of type II valves and they were not seen in the 65 cases of posterior urethral valves in our own material.
 ...
PMID:Posterior urethral valves: theoretical considerations on embryological development. 689 Apr 56

Posterior urethral valves are a common obstructive uropathy causing severe hydroureteronephrosis. Ureteral herniation is very rare and often misdiagnosed. We report a male infant with posterior urethral valves who had increased persistent hydronephrosis despite prior successful ablation. Further examination revealed a paraperitoneal inguinal ureter herniation to be responsible for the clinical status.
 ...
PMID:Scrotal hernia of the ureter in association with posterior urethral valves. 1953 34

Posterior urethral valves represent a congenital barrier at the level of the posterior urethra, which opposes miction. They are located near the prostatic urethra, originating at the verumontanum level, affecting male patients. The ureters are inconstantly dilated; vesicoureteral reflux is met in 2/3 of the cases. The reflux can be secondary to the sub-bladder barrier, but it can also be considered primitive, determined by the intra bladder ectopy of the ureter. The presence of the reflux is interpreted as a severe associated factor. Semiology is rather unusual, positive diagnosis is based on early discovery or antenatally of the impairment, by fetal echography starting from the 28th week of pregnancy, postnatal echography followed by miction cystography, retrograde urethrography and creatinine dosage complete the diagnosis. The treatment is surgical: endoscopic ablation of the valves (in the absence of renal failure), percutaneous pyelostomy, high lateral ureterostomy, and in severe cases vesicostomy and renal transplant. Prognosis depends on how early the impairment is detected, on the degree of pulmonary hypoplasia, on the presence of the vesicoureteral reflux and the possibility of recovering renal function; 1/3 of the newborns develop in time Chronic Renal Failure which requires renal transplant. The studied group comprised male children diagnosed with vesicoureteral reflux their ages ranking between 0 -18 years, admitted to the Pediatric Clinic, Tg. Mures during the last 10 years and children diagnosed and operated with posterior urethra valves at the Surgical Clinic of the "M. S. Curie" Hospital, Bucharest during the last 20 years. Our results show that out of the total number of studied children 25 presented posterior urethra valves and 9 children presented vesicoureteral reflux. We can conclude that the presence of the vesicoureteral reflux is an unfavorable prognosis regarding the degree of renal failure.
 ...
PMID:The prognosis of posterior urethral valves, associated to vesicoureteral reflux in children. 2204 89