Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a series of patients with idiopathic retroperitoneal fibrosis followed for up to 22 years, 21 were treated after ureterolysis of 36 ureters by wrapping the ureters in omentum. Recurrent fibrosis was noted in 2 patients involving 2 ureters. Earlier in the same period 3 patients with 4 ureters were treated by intraperitoneal placement after ureterolysis: in these, recurrence was noted in 2 patients involving 2 ureters. Steroids were used as an adjuvant when ureterolysis was incomplete or for relapse. The omentum appears to afford long-term protection against return of the fibrosis around the ureter.
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PMID:The long-term follow-up of idiopathic retroperitoneal fibrosis. 715 Sep 12

Idiopathic retroperitoneal fibrosis (IRF) may cause ureteric obstruction with renal damage. Ureterolysis with intraperitonealization of the ureter is commonly used as primary treatment. We gave corticosteroids for two years to six patients, four males and two females, between 40 and 56 years of age. one of the patients is in his tenth month of treatment and another in the fourth month. Between 4 and 74 months (mean 40.4 months) after initiation of treatment, kidney function had improved, or was preserved in previously functioning renal units, and the patients were free from symptoms. We conclude that steroids may be used as primary treatment of IRF after histological or cytological diagnosis to exclude retroperitoneal malignancy. Steroids should also be part of the treatment strategy in patients with a more aggressive disease who may need surgery. Patients with IRF should be followed for the rest of their lives after discontinuation of steroid therapy.
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PMID:Successful treatment of idiopathic retroperitoneal fibrosis with steroids. 1735 93