Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A ureter entering a bladder diverticulum almost always has associated vesico-ureteric reflux but rarely obstruction. We present the clinical and radiologic data on a patient with an ectopic ureteral insertion into a bladder diverticulum, with associated obstruction but not vesico-ureteric reflux. Periureteral fibrosis secondary to chronic inflammation is thought to be the underlying cause.
 ...
PMID:Bladder diverticulum associated with ureteral obstruction. 392 35

A series of 46 children treated by the author since January 1972 for congenital posterior urethral valves is presented: 22% were diagnosed at birth, 28% as neonates and 52% in the first 3 months of life. Ninety-three per cent had unilateral or bilateral dilatation of the upper urinary tract at the time the valves were diagnosed and 72% had ureteric reflux. Unilateral reflux occurred into the left ureter twice as often as the right. Renal failure was present at the time of diagnosis in 72% of all of the children but in 83% of those aged less than 3 months. Surface urinary diversion was used minimally during post-operative management and contributed little to the recovery of renal function. Reflux disappeared spontaneously in one-third of the refluxing ureters. Ureteric dilatation subsided spontaneously in 57% of dilated ureters. Surgery was performed mostly for reflux. Non-refluxing ureteric dilatation was made worse by surgery in a few instances and in others the dilatation improved with time rather than as a result of surgery. Renal function returned to normal in over 60% of the children who were in renal failure at diagnosis. Measurement of glomerular filtration rate was the most accurate method of predicting recovery of renal function: a value of less than 50% of normal for age at the time of diagnosis forecast persistent chronic renal failure with all its attendant complications.
 ...
PMID:Management of congenital posterior urethral valves. 397 Nov 7

The authors report their experience on the surgical treatment of 69 infants and children with pyelo-ureteral duplication. Urinary infection was the main revealing symptom (52 cases). Vesico-ureteral reflux was the major associated anomaly (39 cases) involving most often the lower pole ureter; the surgical correction of the reflux was performed according to the technique of Cohen with a favorable outcome in all cases. Because of poorly functioning and dysplastic upper renal segment, partial upper pole nephrectomy was performed in 8 among 12 cases of associated ectopic ureteral orifice and in 9 among 15 cases of associated ureterocele. A reimplantation of the ureter was made possible in 3 cases of ectopic ureteral orifice and in 5 cases of ureterocele with little corresponding renal lesions. With the experience of one neonate who died from septic shock following partial nephrectomy there were no other post-operative complications in this series.
 ...
PMID:[Complications of pyelo-ureteral duplications in children and their surgical treatment. Apropos of 69 cases (78 pathogenic duplications)]. 402 19

The ureterovesical junction was bypassed on the left side with a tube in 9 pigs in order to study the dynamic alterations a vesico-ureteric reflux produces in a previously patent pyelo-ureter. Before bypassing, the median ureteric baseline activity was 1.6-2.0 A.P./min (action potentials/min). During bladder filling the median activity increased by 15-44% to 2.3 A.P./min, together with a slight increase in pelvic pressure. In the refluxing ureters the median baseline ureteric activity was 1.6 A.P./min. During bladder filling the pelvic pressure was the same as the bladder pressure and the median ureteric activity increased by 88% to 3.0 A.P./min. This increase in activity was seen as soon as the bladder filling started. The study adds information to suggest a neurogenic mediated reaction to sudden increases in bladder volume and pressure.
 ...
PMID:Dynamics of the urinary tract during induced vesico-ureteric reflux in pigs. II. 407 Sep 87

The dynamic function of the urinary tract was studied in 6 infravesically obstructed pigs with vesico-ureteric reflux to a total of 8 ureters. After 10 weeks of obstruction a bladder hyperreflexia was found. The baseline ureteric activity in the refluxing ureters was reduced to a median of 0.3 A.P./min (action potentials/min). During bladder filling, the activity increased only slightly to 0.6 A.P./min. In the start the pelvic pressure was more or less independent of the bladder pressure, but when the reflux producing bladder pressure was reached then an abrupt increase in pelvic pressure was seen and thereafter there was pressure equilibration. Ten weeks after release of the obstruction, a minor restitution had taken place. The baseline activity during low urine output was 1.0 A.P./min and during bladder filling it was unaltered, 1.0 A.P./min. Even during high urine output there was no sign of activity increase. 30% of the ureteric contractions stopped in the mid-third of the ureter. Almost all peristalsis was antegrade. Thus, ureters subjected to obstruction and reflux showed deterioration of the peristaltic function and the changes were irreversible.
 ...
PMID:Dynamics of the urinary tract in longterm vesico-ureteric reflux and infravesical obstruction in pigs. IV. 407 Sep 89

The uretero-vesical junction has been examined by micturating cystography in 20 patients after renal transplantation. Intravenous pyelograms were used to investigate the upper urinary tract in 13 of the patients. Persistent urinary infection did not occur in patients without vesico-ureteric reflux. However, both those with reflux of their own and the transplant ureters had persistent infection. When reflux affected the tunnelled transplanted ureter there was no infection, but two patients without a tunnel implant had a persistent urinary infection.
 ...
PMID:Vesico-ureteric reflux after renal transplantation. 493 46

Primary megaureter is a common cause of obstruction of the urinary tract in children. Vesicoureteric reflux is a common lower-tract abnormality. The seemingly paradoxical coexistence of these entities was found to occur nine times over the 10-year period, 1973 to 1983 (in about 2800 children with reflux and about 75 children with primary megaureter). This coexistence should be suspected on voiding cystourethrography when the juxtavesical segment of the megaureter is normal in caliber, the refluxed contrast agent is diluted by urine that is trapped in the ureter, and drainage of refluxed contrast agent into the bladder is impeded. The diagnosis can be confirmed by excretory urography with a catheter draining the bladder to temporarily prevent the reflux. The surgical treatment consists of resection of the distal aperistaltic segment and reimplantation of the ureter.
 ...
PMID:The coexistence of primary megaureter and reflux. 633 47

Eight out of thirty five candidates for renal transplantation at the Bordeaux transplantation center, between 1975 and 1983, all presenting with primary vesico-ureteric reflux, underwent nephro-ureterectomy. The remaining twenty seven were not treated surgically. The authors consider that no operation is required when the ureter is narrow and uninfected, but that dilated refluant and infected ureters should be treated by nephro-ureterectomy, at least unilaterally. In that event, the operation is performed in two stages, with the second stage being performed at the same time as the transplantation.
 ...
PMID:[Surgical indications for primary vesico-ureteral reflux in adult candidates for renal transplantation]. 639 10

Vesicoureteric reflux was produced in eight piglets by opening their bladders and slitting the anterior intravesical wall of the ureter. Cystography confirmed the presence of bilateral reflux in six piglets and unilateral reflux in two. Six to eight weeks later the bladder was again opened and Teflon paste injected in the space behind the intravesical ureter, thereby creating a support for the submucosal ureter. Cystography four to six weeks after injection of Teflon paste showed absence of reflux in all animals. Intravenous pyelography showed obstruction at the vesicoureteric junction in only one of the 14 treated ureters and this was later confirmed at necropsy. Animals were followed up from one to six months and then were killed. Gross examination of the vesicoureteric region showed a well circumscribed subureteric Teflon mass of firm consistency, retaining its shape and position at the site of the injection. Histological examination showed encapsulation of the implant by a thin layer of fibrous tissue and a foreign body granulomatous reaction with histiocytes and giant cells within the implant. Hence it is technically feasible to correct experimentally produced vesicoureteric reflux in the piglet by intravesical injection of Teflon paste--a relatively inert material. It may now be possible to treat vesicoureteric reflux in man by endoscopic injection of Teflon behind the intravesical ureter.
 ...
PMID:Correction of experimentally produced vesicoureteric reflux in the piglet by intravesical injection of Teflon. 642 63

Of 49 children with renal ectopy, 25 (51%) had hydronephrosis on excretory urography. Dilatation of the renal pelvis was the result of primary ureteropelvic junction obstruction (17 children), significant vesicoureteral reflux (6 children), or extrarenal pelves and calices with renal malrotation producing apparent ureteropelvic junction obstruction (2 children). Vesicoureteral reflux was a common finding in these patients, occurring in 52% of those with crossed renal ectopy and in 70% of those with pelvic kidney. The need for surgical intervention results from either (1) ureteropelvic junction obstruction secondary to high insertion of the ureter on the renal pelvis or (2) vesicoureteral reflux secondary to aberrant migration of the lower ureter. Most children with renal ectopy and ureteropelvic dilatation require surgical reconstruction at the renal level. In selected patients, ureterocalicostomy is an attractive alternative to conventional pyeloplasty and appears to afford improved drainage with superior results.
 ...
PMID:Ureteropelvic junction obstruction in children with renal ectopy. 650 10


<< Previous 1 2 3 4 5 6 7 8 9 Next >>