Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study covers 230 Wetheim operations. Sixty-seven patients had Stage II carcinoma (29.17%), and 163 patients had Stage I carcinoma (70.80%). Until 1968, x-ray treatment was used after the Vienna Wertheim operation, but since then the approach has changed. Tele- and brachio-cobalt therapy is now included. The operative death-rate was 0.96%. One patient died of peritonitis, another of renal uremia. In the Vienna Wertheim group, ureteric fistulae occurred in 7.23% of patients. With the introduction of mesentery and the ureter roof into the Wertheim procedure, ureteric fistulae have currently disappeared from the material examined (133 cases), although the operation was more radical than the classical Vienna Wertheim technique. Urography examination shows that changes are twice are frequent, and later anatomical changes in the urinary system are more than twice as frequent, with the Vienna Wertheim technique. A considerable number of early hydronephroses were found to have disappeared during the first year. Urography examination has shown that the mesentery of the ureter also has a beneficial effect on the flow of urine. It serves in the prophylaxis of fistulae, and prevents greater displacement of the ureter in the parametrial vacancies.
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PMID:Wertheim hysterectomy: a ten year experience. 26 62

During a 4-year-period, 5 cases of ureteral obstruction by aorto-iliac aneurysm were detected. Over the same period 50 aorto-iliac aneurysms were resected. One of the 5 patients was not operated on. In the remaining 4, the aneurysm was resected and replaced by a Dacron bifurcation graft. Nephrectomy was performed in the first 2 patients. Autotransplantation of the remaining kidney was carried out in one case following enucleation of a hypernephroma ex vivo. In the other 2 patients, ureterolysis and intraperitoneal transposition of the ureter was performed in conjunction with resection of the aneurysm. One of the latter patients suffered from uraemia due to a non-functioning kidney on the other side. Ureteral obstruction appears to be a relatively common complication of aorto-iliac aneurysm. Elective evaluation of patients with aortic aneurysms should include late aortograms visualizing the ureters.
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PMID:Ureteral obstruction by aorto-iliac aneurysms--a common complication? 38 45

Carcinoma metastatic to the ureter is uncommon, only 160 patients having been reported upon to date. During a ten year period, 82 patients with ureteral obstruction, secondary to metastatic disease, were seen at the UCLA Hospital. A critical analysis of the records of these patients revealed important clinical and diagnostic criteria to aid in the evaluation and treatment of extrinsic ureteral obstruction. Tumors of the cervix, prostate, breast and colon-rectum were the most common primary lesions to metastasize to the ureter. Subtle changes in urinary symptoms or in laboratory values should alert the physician to the possibility of ureteral involvement. Early detection of metastatic ureteral obstruction prior to the ravages of uremia may allow time for more aggressive use of adjuvant therapeutic modalities that would, at a later stage of the disease, be ineffectual or contraindicated.
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PMID:Ureteral obstruction secondary to metastatic tumors. 41 34

The kinetics for mesangial uptake and transport of radiolabeled aggregated human immunoglobulin (Ig)G (AHIgG(125)I) deviated markedly from normal in male Sprague-Dawley rats with ureteral obstruction. Four experimental groups, each containing 25 rats, were used: (a) bilateral ureteral ligation (BUL) with release of one ureter 24 h later; (b) unilateral ureteral ligation with release 24 h later [UUL(R)]; (c) unilateral ureteral ligation without release (unreleased) [UUL(U)]; (d) uremia-control, which consisted of rats with ligated left ureter and a severed right ureter. A similar number of sham-operated rats served as control for each group. AHIgG(125)I (45 mg/100 g body wt) was given intravenously 1 h after release of the ureteral obstruction (25 h after ureteral obstruction or sham surgery). Groups of five control and five experimental animals were sacrificed at 2, 4, 8, 16, and 24 h after injection. At all time intervals, concentrations of AHIgG(125)I in isolated glomeruli from control animals were similar to values obtained from nonobstructed kidneys of UUL(U) and UUL(R) rats: a linear decrease in concentration over a period of 24 h was observed when the logarithm of glomerular AHIgG(125)I concentration was plotted against time. Aberrations in the kinetics were apparent in obstructed kidneys but not in liver, spleen, or blood concentrations of AHIgG(125)I: (a) At 2 h in all obstructed kidneys, glomerular concentration of AHIgG(125)I was markedly reduced. (b) In BUL (released or unreleased), glomerular concentrations of AHIgG(125)I from 4 to 16 h were congruent with 10-fold those in UUL(U) or UUL(R) kidneys. (c) The significant decline in glomerular concentration between 4 and 16 h in control and nonobstructed kidneys was not observed in UUL(R), UUL(U), or BUL (released or unreleased) kidneys; in all obstructed kidneys, a plateau in glomerular concentrations of AHIgG(125)I was observed between 4 and 16 h. (d) After 16 h at a time when the blood level of AHIgG(125)I had decreased to 3% of initial values, there was progressive fall in glomerular AHIgG(125)I. Similar results were obtained in the uremia-control group in rats, which indicated that uremia per se had no measurable effect on mesangial kinetics. These studies demonstrate that ureteral occlusion induces alterations in mesangial uptake (afferent limb) and egress (efferent limb) of macromolecules. Particularly evident is the "blockade" of the efferent limb which is demonstrable at high blood levels of AHIgG(125)I. These alterations in the transit of macromolecules through the mesangium may be mediated in part by the hemodynamic changes that accompany ureteral obstruction.
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PMID:Mesangial function in ureteral obstruction in the rat. Blockade of the efferent limb. 50 Aug 7

Elevated levels of fibrinogen/fibrin degradation products (FDP) occur in uremia, and have been thought to be in part related to intravascular coagulation in the kidney. More recent data indicated that delayed catabolism of fibrinogen fragment D occurred in anephric animals. To further evaluate FDP catabolism in the kidney, turnover studies of purified dog 131I-Fg-D and 125I-Fg-E were performed on dogs before and after acute subtotal nephrectomies, and later during chronic uremia. 131I-fibrinogen clearances were also perfomed. Slowed catabolism of Fg-D and Fg-E was observed in both the acute and chronic uremic stages. Altered urinary excretion was not a factor as only minimal amounts of Fg-D and Fg-E were excreted in the urine of the control animals. In the 131I-fibrinogen studies, there were significant changes in plasma volume, fibrinogen t 1/2, and intravascular/extravascular distribution, but not in fractional catabolic rate. To differentiate fully, the effects of uremia from those of loss of catabolic renal tissue, the Fg-D and Fg-E turnover studies were repeated on other animals with intact kidneys whose ureters were diverted into the peritoneum and compared to subsequent studies after total nephrectomy. The control and ureter-severed studies had the same clearance pattern, whereas decreased catabolism occurred in the nephrectomized dogs. The results demonstrate uremia per se does not have a major effect upon the catabolism of fibrinogen, Fg-D, and Fg-E. Loss of renal tissue does impair the clearance of Fg-D and Fg-E, indicating these proteins are normally catabolized in part by the kidneys. Thus elevated plasma FRA in uremic patients may reflect decreased Fg-D and Fg-E catabolism rather than increased FDP production from primary or secondary fibrinolysis.
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PMID:The roles of renal catabolism and uremia in modifying the clearance of fibrinogen and its degradative fragments D and E. 93 24

Significant portion of the urologic and nephrologic patients in Yemen are treated because of the early and late complications of schistosomiasis (bilharsiasis). During two years 79 patients with renal insufficiency and complications have been examined and treated by the authors. In combination with moderate restricted renal functions hepatosplenomegaly and signs of portal hypertension were observed in female patients. Granulomatous infiltration, calcification and malignous tumour of the urinary bladder was found in men. Stricture of the ureter, uni- or bilateral consecutive hydronephrosis was detected frequently. In addition to inflammatory components bladder, ureteral and renal stones were verified. In the course of treatment 45 percutaneous nephrostomies were performed and an anterograde pyelography was carried out in 60 patients. Ureteral recanalisation was accomplished by means of an ureter stent in 8 cases. Because of serious uremia maintenance haemodialysis was performed in 52 patients. The aim of this work is to contribute to recognise the disease in early stage and emphasize the importance of establishing diagnosis as early as possible and stress the role of the appropriate causal and symptomatic treatment.
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PMID:[Late urinary tract complications of schistosomiasis]. 181 Dec 3

Morphological investigations of the urethra, urinary bladder (2 localizations), ureter, renal pelvis and kidneys were performed in sows with Corynebacterium suis infection. The first stages of the disease were characterized by changes of the transitional epithelium in the bladder where epithelial vacuolisation, goblet cell differentiation, leucocytic infiltrations, and haemorrhages occurred. In chronically affected animals different stages of a mucopurulent, partly erosive to ulcerative cystitis were observed. Furthermore, chronic cystitis was characterized by polypoid mucosal proliferation and bacterial accumulations. Ureter and urethra showed signs of a mild purulent inflammation. In the renal pelvis there was a severe fibrinopurulent and necrotizing pyelitis which was accompanied by bacterial invasions. The parts of the renal pelvis without desquamation of the transitional epithelium undergo mucoid degenerations. The final stage of the disease is characterized by severe fibrosing chronic interstitial nephritis leading to death of the animals due to uraemia.
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PMID:[Corynebacterium suis infections in swine. 2. Morphological findings in the urinary tract with special reference to the bladder]. 208 May 4

Thirteen patients who received surgical treatment for histologically proven retroperitoneal fibrosis were reviewed retrospectively. All patients had idiopathic disease, bilateral in 11 patients. Elevated ESR occurred in 12 patients and in eight patients the hemoglobin value was decreased preoperatively. Intravenous urography on admission was normal in six kidneys, excretion was delayed in four kidneys and another four upper urinary tracts were dilated. No excretion was seen in four kidneys and eight kidneys were not examined urographically because of uremia. Ureteric obstruction was treated surgically by ureterolysis alone in two ureters, by ureterolysis and lateral displacement in eight ureters, by ureterolysis and intraperitonealization in 12 ureters and by ureterolysis and omental wrapping in two ureters. After primary surgery one nephrectomy was performed because of a nonfunctioning kidney. Postoperatively 19 kidneys are functioning well, in three the function is poor and there is no function in three kidneys. According to our experience the cornerstone of the surgical treatment is complete and extensive ureterolysis and permanent displacement of the ureter from the area of fibrosis.
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PMID:Surgical treatment of ureteric obstruction in idiopathic retroperitoneal fibrosis. 318 26

In order to evaluate the potential role of hyperkalemia and metabolic acidosis on the disturbances of carbohydrate metabolism normally seen in uremia, a specific model of acute uremia devoid of hyperkalemia and severe metabolic acidosis was chosen. Therefore, rats were deprived of potassium prior to induction of acute uremia. Potassium depletion caused a significant decrease of muscle and liver glycogen due to activation of phosphorylase kinase, whereas glycogen concentration in heart muscle was unchanged and elevated in the kidney of sham-operated and ureter-ligated animals. In contrast, glucose concentrations were enhanced in the liver and the kidney, unchanged in heart muscle and decreased in skeletal muscle. We conclude that carbohydrate abnormalities occur in acute uremia despite normokalemia and mild metabolic acidosis. Furthermore, acute uremia accompanied by prior potassium depletion results in no net effect on cardiac glycogen metabolism but stimulates glycogenolysis in both skeletal muscle and the liver.
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PMID:Acute uremia following dietary potassium depletion. II. Effect on tissue carbohydrate composition. 358 86

From 1956 to 1985, autopsy was done on 17 lung cancer patients in our hospital. There were two patients with focal metastasis as the presenting symptom without any primary cancer manifestations. One patient was admitted for severe right epigastric pain followed by severe pain in the left epigastrium. The chest film revealed nothing except some indefinite inflammatory lesions in the left upper lung. The patient died of uremia in 6 months. A primary carcinoma of 2 cm in diameter in the left lower lung was found on autopsy, which widely spread to the right lung, ovaries, upper segment of the left ureter, peribronchial and periaortic lymph nodes. Histological diagnosis was poorly differentiated adenocarcinoma. The other patient had destruction of the sphenoid bone with cranial nerve paralysis and hypothalamic syndrome at first. The primary cancer, a poorly differentiated adenocarcinoma of 2 X 3 X 1.5 cm in size, was found in the right upper lung on autopsy. Focal metastatic symptom as the initial presentation of lung cancer is rare. These tumors, as small lesions, frequently occur in the peripheral part of the lung. However, the site in which the presenting symptom develops may not necessarily be the place prone to metastasis. The presenting symptom, in turn, would depend upon the tendency of causing symptoms in the involved site. The author suggests that careful searching and identifying of the pulmonary lesion be routinely done for patients with metastatic carcinomatous symptoms only.
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PMID:[Focal metastatic symptom as the initial presentation of lung cancer--report of two autopsied cases]. 365 19


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