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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aim of our present work was to investigate a new method to study the three-dimensional arrangement, the length and the diameter of the different parts of the renal tubules. The ureter was cannulated after blocking the urinary flow with a binding of the ureter itself at its intermediate third, and injected in it against flow a synthetic resin (Mercox) normally used for vascular corrosion casts. It was demonstrated that the binding maintained only for 24 hours is adequate for morphological studies of the urinary tracts from papillar ducts until the Henle's loop. On the contrary the binding maintained for 7 days induced marked changes in the tubular architecture similar to the first anatomo-pathological changes of the nephrosclerosis following a chronic obstructive nephropathy.
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PMID:[Use of synthetic resin cases for the scanning electron microscopic study of the kidney tubule system]. 207 95

The surgical intervention on 261 ureterovesicular segments was performed in 202 patients aged 3 months-14 years. All the patients presented with megaureter varying in forms: refluxing megaureter (147 cases), nonrefluxing megaureter (94 cases), megaureter with ureterocele (20 cases). Histological investigations demonstrated congenital structural changes of the same type to be a morphological basis of diverse megaureter forms. These structural changes involved muscular and connective tissue elements of the ureteral wall. Being qualitatively continual, the components varied in quantity thus producing different maldevelopments. Urodynamic dysfunctions depended on ureteral dysplasia severity and form. Clear-cut outlines in the x-ray image of the refluxing, nonrefluxing and megaureter with ureterocele resulted from the condition and structure of the ostium ureteris and its submucosal segment. The same pathogenetic origin of megaureter forms gave grounds for conducting operations of the same type, resection of the defective ureter along with the ostium and its replacement for a morphofunctionally competent segment with formation of another ostium. The response to the surgery was assessed in 196 patients (249 ureters). The follow-up lasted from 1.5 to 22 years. Good responses were achieved in 90%, satisfactory in 3.2%, poor in 6.8% of the surgical patients. High efficacy of the operation says in favour of its pathogenetic validity. The megaureter correction created favourable conditions for renal growth and development. However, in 7 cases the improvement has changed for progressive nephrosclerosis with decline in the organ function or arterial hypertension. The ureter in such cases was in stable good condition. The above observations suggest the necessity of further investigations of this problem and continuation of the patients' follow-up.
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PMID:[The correction of primary megaureter in children. The late results]. 801 14

We studied the condition and development of 50 kidneys in 45 patients 10-30 years after surgical correction of megaureter. We made resection and neoimplantation of the ureter according to the antireflux technique. By x-ray findings, we estimated area of the kidney, renocortical index and compared them with visual assessment of the condition of the kidney and its pelvicocalicyal system. We have found that correction of the megaureter creates favourable conditions for development of the kidney as shown by good growth of the kidney (area increased 1.5-3.5 fold) in a stable renocortical index. This indicates stabilization of nephrosclerosis and large area of renal parenchyma. However, kidney growth was accompanied with developing nephrosclerosis in 7 cases, in 1 case nephrosclerosis terminated with secondary contraction and a decline of renal function. The condition of the kidney varied due to many factors such as the condition of the immune system, age of the patient, virulence of the microflora, etc., but the key role for the kidney belonged to condition of renal parenchyma before surgical intervention. The data of light optic (53 cases) and electron-microscopies (3 cases) examinations of renal biopsies demonstrated that renal lesions were characterized by congenital structural disorders such as low number of nephrons, the presence of canalicular and glomerular microcysts and other manifestations of hypoplastic dysplasia. Inflammatory infiltration of the cortical and medullary layer interstitium aggravated severity of renal lesion. Various correlation and severity of congenital and aquired lesions characterized condition of the kidney in each individual case. Thus it is necessary to conduct a long-term follow-up and update methods of therapy.
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PMID:[Renal development long after correction of primary non-refluxing forms of megaureter in children]. 1744 57

A concept is proposed laying emphasis on the involvement of cytokines, growth factors, prostaglandins, and nitrogen oxides in the mechanism of formation of reflux-nephropathy in children. It is shown that enhanced production of mediators of inflammation and humoral growth factors in patients with vesico-ureter reflux depends on the degree of infiltrative and sclerotic changes in the kidneys. The accompanying dysbalance of pro- and anti-inflammatory cytokines due to increased endogeneous production of TNF-alpha and concomitant decrease of daily BL-10 excretion constitutes an unfavourable prognostic factor of reflux-nephropathy. There is evidence that inclusion of ACE inhibitors (Enap) in therapy of vesico-ureter reflux during 6 months leads to a marked improvement of the structural and functional state of the kidneys. It suggests high renoprotective potential of these preparations and the possibility of their use for prophylaxis of nephrosclerosis in children.
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PMID:[Biologically active compounds in the mechanism of formation of reflux-nephropathy in children]. 1918 11