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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a consecutive series of 88 cases of carcinoma of the kidney and upper urinary tract seen at one hospital, 31 had malignant urothelial tumours of the renal pelvis or ureter. Forty-two per cent of these transitional-cell carcinomas occurred in patients with renal papillary necrosis following upon prolonged and heavy analgesic ingestion. Other possible aetiological factors were heavy cigarette smoking (61% of cases), long standing urinary obstruction or infection (23%) and possible occupational exposure (6%); in only four cases (13%) was there no identifiable aetiological factor. Those cases with analgesic nephropathy were characterised by renal functional impairment, hypertension and interstitial nephritis, but there was no difference in the clinical behaviour or pathological appearances of the tumours in the two groups. The clinical and experimental evidence that certain metabolites of phenacetin are carcinogenic is reviewed.
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PMID:Analgesic abuse, renal parenchymal disease and carcinoma of the kidney or ureter. 27 65

Urothelial tumours of the upper urinary tract are rare, but their incidence increases in subjects suffering from phenacetin nephropathy, Balkan nephropathy and infected pyelic calculi. In order to act on the urothelium through the urinary way, a cancerigenic substance must (1) be eliminated with the urine; (2) be absorbed by the urothelium; (3) remain in the tissue for a certain length of time. Any situation leading to a prolongation of intra-tissue stasis favours the action of carcerigenic substances. The hypothesis is put forward that interstitial nephritis, by impeding the reabsorption from the pelvis by pyelo-lymphatic reflux and by making more difficult the lymphatic drainage of the pyelic and ureter walls, leads to a condition favouring carcinogensis, especially if the subject is exposed to contact with even not very active carcinogens. It is possible to foresee that in future the incidence of upper urinary tract tumours should increase in chronic uraemic patients under dialytic treatment and in transplant patients.
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PMID:Chronic interstitial nephritis as a cause of tumours of the upper urinary tract. A hypothesis. 49 41

Renal artery aneurysms were diagnosed in 11 patients (9 boys) aged 1 to 14. The examinations were carried out for vasorenal hypertension in 4 cases, for bladder-ureter reflux, hematuria, nephroptosis in 4, ureterohydronephrosis in 2 cases, and for interstitial nephritis. Aneurysms of the major trunk of the renal artery, mostly oval-shaped, 11 x 14 to 25 x 28 mm in size, were detected in 4 patients, intrarenal aneurysms 2 x 3 to 5 x 6 mm in size in 7 cases. The share of aneurysms among uronephrologic conditions in children was found to be 1.54%, among vasorenal hypertension cases, 4.3%. Vasorenal hypertension is the main optional sign of aneurysms of the main trunk of the renal artery, whereas for intrarenal aneurysms such sign is hematuria.
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PMID:[Renal artery aneurysms in children]. 130 2

Morphological investigations of the urethra, urinary bladder (2 localizations), ureter, renal pelvis and kidneys were performed in sows with Corynebacterium suis infection. The first stages of the disease were characterized by changes of the transitional epithelium in the bladder where epithelial vacuolisation, goblet cell differentiation, leucocytic infiltrations, and haemorrhages occurred. In chronically affected animals different stages of a mucopurulent, partly erosive to ulcerative cystitis were observed. Furthermore, chronic cystitis was characterized by polypoid mucosal proliferation and bacterial accumulations. Ureter and urethra showed signs of a mild purulent inflammation. In the renal pelvis there was a severe fibrinopurulent and necrotizing pyelitis which was accompanied by bacterial invasions. The parts of the renal pelvis without desquamation of the transitional epithelium undergo mucoid degenerations. The final stage of the disease is characterized by severe fibrosing chronic interstitial nephritis leading to death of the animals due to uraemia.
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PMID:[Corynebacterium suis infections in swine. 2. Morphological findings in the urinary tract with special reference to the bladder]. 208 May 4

We surgically produced high-grade sterile vesicoureteral reflux in infant monkeys by unroofing the intravesical ureter and partially ligating the bladder neck. Half of the monkeys developed a decrease in renal function and were found to have interstitial nephritis. We found that this was due to a high resting bladder pressure, which affected the function and structure of the ureter. Thus, when a functional obstruction occurs in the refluxing ureter, renal function may be lost even when the urine is sterile. This situation is like that occurring in the patient with posterior urethral valves.
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PMID:Effects of sterile high pressure vesicoureteral reflux on the monkey. 641 37

Bacterial urinary tract infections can lead to acute or chronic, nonspecific or specific lesions of the kidney, renal pelvis, ureter, urinary bladder, and urethra. The inflammatory process may be limited to the kidney and/or to segments of the urinary tract. The most important and frequent pathoanatomic alterations were defined; the microscopic findings were described and supplemented with selected macroscopic and pathogenetic aspects. Juvenile bacterial interstitial nephritis was differentiated from adult bacterial interstitial nephritis on the basis of age-dependent anatomic conditions.
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PMID:[Morphologic substrate in bacterial urinary tract infections (author's transl)]. 701 33

The authors have reviewed 80 cases of ectopic ureter in 74 patients (62 women and 12 men). In most cases the abnormality involved the upper part of a double ureter system, and the extravesical openings were not only ectopic (located within or, most commonly, below the vesical sphincter in women), but also malformed with stenosis and/or reflux. The kidneys drained were damaged by dysplasia and/or interstitial nephritis. The presenting symptoms were fever, abdominal pain and disorders of micturition; incontinence, exclusively found in women, took only second rank. The purulent urine discharged could pass for leucorrhoea. Diagnosis was made by intravenous urography and by clinical or endoscopic finding of the ectopic opening.
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PMID:[Extravesical openings of ectopic ureters: diagnostic problems (author's transl)]. 707 36

In 300 urological patients with long-term intake of phenacetin-containing compounds, renal (papillary necrosis, chronic interstitial nephritis) and extrarenal manifestations appeared after an average latency period of 20 years. Course and prognosis primarily depend on the successful cessation of analgesics and the elimination of the accompanying infection. In the last decade, an increase of transitional cell carcinoma induced by analgesics has been observed. 31 of our patients presented a tumor of the urothelium (i.e. 10.3%) 26 patients presented isolated carcinoma of the bladder, 2 persons were diagnosed as having cancer of the bladder and the renal pelvis, and 1 patient had cancer of the bladder and the ureter. Only 2 persons suffered from isolated carcinoma of the renal pelvis. A further increase of these specific cases if expected.
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PMID:Analgesic nephropathy and phenacetin-induced transitional cell carcinoma - analysis of 300 patients with long-term consumption of phenacetin-containing drugs. 728 4

A 3-year-old Thoroughbred colt was presented for evaluation of azotemia and anorexia. Physical examination revealed a ureterolith in the left ureter, approximately 10 cm from the bladder, which was thought to obstruct urine flow by approximately 90% when viewed cystoscopically. Ultrasonographic examination of both kidneys revealed indistinct corticomedullary junctions, and the right kidney was more hyperechoic. A percutaneous biopsy of the right kidney revealed chronic interstitial nephritis with marked interstitial medullary fibrosis. Medical therapy consisting of IV fluids, sodium chloride PO, and ammonium chloride PO was initiated. Ureteroscopic electrohydraulic lithotripsy via a perineal urethrostomy was used to successfully remove the stone. Klebsiella oxytoca, which responded to oral enrofloxacin therapy, was cultured from the urine after surgery. Azotemia resolved and the horse resumed training.
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PMID:Resolution of a left ureteral stone using electrohydraulic lithotripsy in a thoroughbred colt. 852 27

The present work was conducted to investigate the possibility of inducing renal lesions in chickens subcutaneously or orally inoculated with E. coli [E. coli O1K67(B12)], Staphylococcus aureus and Actinomyces pyogenes. The strains were previously isolated from the kidneys of broilers showing different pathological lesions. The gross lesions observed in the kidneys included enlargement, congestion, haemorrhagic spots in addition to dilatation and distension of the ureters. The microscopic lesions were mainly interstitial nephritis. The lesions were acute and changed gradually to subacute or chronic nephritis. The glomerular lesions were not common. The wall of the primary branches of the ureter and the ureters was heavily infiltrated with inflammatory cells, also granular and albuminous casts were seen in the renal tubules. The lesions were not related to the inoculated pathogen, although they were more severe in chickens inoculated with E. coli and Staph. aureus more than in Actinomyces pyogenes. Reisolation of the inoculated pathogens was more successful from the birds inoculated subcutaneously than from those infected orally.
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PMID:Experimental induction of renal lesions in chickens. 963 51


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