Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study tested the ability of the converting enzyme inhibitor, captopril, to lessen the severity of acute renal failure following temporary occlusion of the renal artery. In the control group, 11 dogs were anesthetized with halothane, and the left kidney was isolated through a midline incision. The renal artery, vein, and ureter were then clamped for 120 min. Immediately after occlusion, the kidney was flushed with 40 ml of saline at 34 degrees C. When the clamp was released, a contralateral nephrectomy was performed and the animal allowed to recover. Serum creatinine and blood urea nitrogen levels were followed on a daily basis thereafter. Thirteen captopril-treated dogs were treated in the same fashion except that captopril (1.25 ml/kg, i.v.) was given prior to the 120-min period of renal ischemia. Three of 11 (27%) control dogs survived, whereas 10 of 13 (77%) captopril-treated animals survived (P less than 0.05). Serum creatinine (5.4 +/- 2.5 mg/dl) and serum urea nitrogen (96 +/- 33 mg/dl) peaked on day 8 in the captopril-treated group and were consistently lower than in the untreated group. These observations suggest that captopril is useful when temporary interruption of the renal circulation is encountered, such as in renal autotransplantation, cadaveric renal transplantation, and renal revascularization. These data also suggest that inhibition of the renin-angiotensin system may lessen the severity of acute renal failure following renal ischemia.
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PMID:Enhancement of recovery in postischemic acute renal failure with captopril. 637 20

The occult ureter in a duplex kidney should be recognized during the procedure time even if the intravesical orifice has not been visualized. In the opposite case it is possible to do some therapeutic errors. That is the reason why the authors report four new cases with five occult ureters in a duplex kidney. One is diagnosed during a second procedure for removing a stenosis on an unfortunate reimplantation with an acute renal failure. Four occult ureters were found during an intervention for a vesicorenal reflux on the functional ureter. The upper pouch was blind without any renal parenchyma in three cases and in two cases there was a little renal dysplasic parenchyma. In the four ureters where we have been able to observe the down pouch we have not seen an orifice in three cases and in one case the orifice was in ectopic position. Commentaries are done about the clinic context the similarities between this unrecognised ureter and ureterocele. Therapeutic approach is precised with the interest of an opacification during the procedure of all supplementary conduct discovered while the dissection of an ureter.
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PMID:[Unrecognized ureteral duplication (author's transl)]. 722 50

We report on a patient with a known diagnosis of adenocarcinoma of the prostate who had acute renal failure. An excretory urogram showed bilateral ureteral obstruction and retrograde ureteral catheterization was attempted. Because the retrograde catheters could not be passed into the bladder percutaneous nephrostomies were placed immediately. Dissection of the right ureter showed complete intrinsic occlusion by a multinodular tumor, with no evidence of secondary extension at the ureterovesical junction on the right side or circumferential spread along the involved ureter.
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PMID:An unusual presentation of intrinsic ureteral obstruction secondary to carcinoma of the prostate: a case report. 746 72

We report a 26-month-old child diagnosed with prune-belly syndrome and end-stage renal disease who received intraperitoneal implantation of an adult cadaveric renal graft which functioned very well for approximately 6 weeks. The patient then presented with acute renal failure which was proved to be secondary to torsion of the graft, twisting the artery and vein. The ureter was wrapped 360 degrees around the graft. These conditions resulted in loss of the graft and nephrectomy. Ours is the second report of such an occurrence; the first was from a living-related kidney donor. We believe the lack of abdominal wall tone contributes to graft mobility and risk of torsion of the kidney. We recommend that nephropexy be considered in these patients. In addition, the risk of torsion must be at the forefront of the differential diagnosis in a prune-belly renal transplant patient with acute onset of oliguria. Renal sonography with Doppler should be employed as soon as possible so that the graft can be saved.
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PMID:Renal allograft torsion associated with prune-belly syndrome. 774 30

We discuss the effectiveness of in situ extracorporeal shock wave lithotripsy (ESWL) for the ureteral stones causing acute renal failure in 5 patients (4 men and 1 woman, mean age 56.2 years). Three of them had a sole functioning kidney, one had a solitary kidney and the other had bilateral ureteral stones. The obstructing stones were located in the upper ureter in one, lower ureter in 2, upper and lower ureter in one and bilateral upper ureter in one with the average length of the stones being 9.2 mm. We used the EDAP LT-01 device for these stones. The obstructing stones were successfully disintegrated by ESWL alone in three cases, but could not be disintegrated in the other 2 cases in which the obstruction had occurred gradually or there were multiple stones. In the latter 2 cases, we performed ESWL again with percutaneous nephrostomy or hemodialysis. We thus believe that ESWL is a safe and effective procedure and is the first choice of emergency treatment for some ureteral stones causing acute renal failure. However, the subject is limited to acute cases, and the stone must be easily detected, single with its size being less than 12 mm and composed of calcium.
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PMID:[In situ extracorporeal shock wave lithotripsy for ureteral stones causing acute renal failure]. 819 66

We investigated the effect of acute renal failure on the neurotoxicity of ranitidine in rats. Experimental acute renal failure was produced by bilateral ureteral ligation. Ranitidine was infused into the ureter ligated (UL) and control rats at the rate of 3.25 mg/min through the jugular vein until the onset of clonic convulsion. In UL rats, the onset time of convulsion was shorter and ranitidine concentrations in plasma and cerebrospinal fluid (CSF) were lower than those of control rats. However, the ranitidine concentration in the brain at the onset of convulsion was not different between the UL and control rats. From these findings, we concluded that acute renal failure is one of the risk factors for ranitidine neurotoxicity, and the increased sensitivity to the drug on the central nervous system may contribute to the increased toxicity of ranitidine in renal failure.
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PMID:Effect of renal failure on neurotoxicity of ranitidine in rats. 885 Mar 34

Urinary tract obstruction is a common cause of acute renal failure (ARF). During unilateral ureteral obstruction (UUO) arteriolar vasoconstriction, increase in tubular pressure, and ultrafiltrate retrodiffusion occur. We studied renal function of rats with surgical UUO for 24 hr. After this period of UUO, the contralateral kidney was removed and the right ureter was deobstructed. The control uninephrectomized group consisted of normal rats submitted to left uninephrectomy (UNx). Functional studies were performed 12 and 24 hr, and 7 days after deobstruction and UNx. We measured creatinine clearance, and fractional excretion of sodium and lithium. Using conventional formulas we calculated fractional proximal and distal sodium reabsorption. Initially we observed a reduction in glomerular filtration rate (GFR) after deobstruction (12 and 24 hr). However, after 7 days, the GFR was significantly higher in deobstructed rats than in controls (340.3 +/- 18.3 vs. 286.4 +/- 9.3 microL/min/100 g, p < 0.01). The dry kidney weight was also increased in these rats. The fractional sodium excretion was increased in deobstructed rats, mainly in early studies (12 and 24 hr). Whereas fractional proximal reabsorption was reduced in both groups, the fractional distal reabsorption was significantly decreased in the deobstructed group compared to UNX controls (93.9 +/- 0.9 vs. 98.9 +/- 0.1% after 24 hr, p < 0.01). Our data showed that UUO influenced both glomerular and tubular functions. A salient finding was the overcorrection of GFR 7 days after deobstruction. The renal release of hormones and growth factors could mediate these alterations in renal function through their vascular, tubular, and proliferative actions.
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PMID:Acute ureteral obstruction and glomerulotubular function in rats. 910 12

We investigated the effect of acute renal failure on the neurotoxicity of enoxacin (ENX) in rats. Experimental acute renal failure was produced by bilateral ureteral ligation. ENX was intravenously infused to ureter ligated (UL) and control rats, and its concentration in plasma, brain and cerebrospinal fluid (CSF) was compared. Plasma concentration of ENX increased rapidly in UL rats as compared with control rats. Brain/plasma concentration ratio (Kp)-time profile of ENX was similar in UL and control rats. Brain concentration of ENX at the occurrence of convulsion did not depend on the infusion rate, suggesting that in the brain tissue it equilibrates rapidly with the site of action for clonic convulsion. Brain concentration of ENX in UL rats at the occurrence of clonic convulsion was lower than that in control rats. A similar tendency was also observed with CSF concentration. In conclusion, the potentiation of neurotoxicity of ENX with acute renal failure may be caused by not only decreased capability for renal elimination of ENX but also increased sensitivity to convulsant activity of ENX in the central nervous system.
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PMID:Effect of acute renal failure on neurotoxicity of enoxacin in rats. 930 Jan 46

We report a case of 33-yr-old-male after orthotopic renal transplantation 18 years ago, presenting with sudden anuria during Miles' operation. This anuria was caused by temporal compression of the transplanted kidney by retractor, neither by acute renal failure, the rejection nor the damage of the ureter by the surgical procedure. This case indicates that in the anesthetic management after renal transplantation, we have to be careful about renal dysfunction due to surgical procedure or positioning, in addition to side effects and pharmacokinetics of drugs used perioperatively.
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PMID:[Unexpected anuria during Miles' operation in a renal-transplant patient]. 949 5

An 80-year-old woman was referred to our hospital because of irregular genital bleeding. An abnormal mass was found in the uterine cervix, and diagnosed as non-Hodgkin's lymphoma, diffuse large B cell type. Soon after admission, the patient became anuric and was given a diagnosis of acute renal failure due to obstruction of the ureter. She was immediately placed on dose-reduced CHOP and radiotherapy of 15 Gy. As a result, not only did the malignant lymphoma go into remission, but diminished renal function was alleviated. Because malignant lymphoma of the uterus is extremely rare, it exact biocharacteristics are not well understood. We are unaware of any previous report concerning uterine lymphoma complicated by renal failure.
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PMID:[Primary non-Hodgkin's lymphoma of the uterine cervix complicated by acute renal failure due to ureter obstruction]. 969 77


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