Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0403608 (ureter)
 9,655 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Albino rat experiments were undertaken to examine the protective action of heparin and the specific features of secondary renal ischemic changes when the agent was administered in different doses during revascularization. Ischemia was induced by 90-min ligation of the renal vessels and the ureter. Heparin was found to have a dose-dependent capacity to prolong rats' survival after ischemia of a single kidney. There were qualitative distinctions of morphological changes in the heparin-treated kidneys as compared with those in the control.
 ...
PMID:[Features of reoxygenation-induced damage to ischemic kidney during heparin administration]. 782 46

Ex vivo renal artery reconstruction is a technique used to repair renal vascular lesions not amenable to conventional in situ methods of revascularization, either because of anatomical considerations or the inability of the kidney to tolerate the extended period of warm ischemia necessary to complete the procedure. In general, this refers to lesions at or beyond the division of the main renal artery into the segmental branches. The kidney is mobilized to the level of the abdominal wall after dividing the origins of the renal artery and vein from the aorta and inferior vena cava, respectively. The ureter is left intact. The kidney is cooled by placing it in an external slush bath and by perfusion through the renal vessels of a cold electrolyte solution. A suitable conduit (usually saphenous vein or hypogastric artery) is then prepared for grafting. After completion of the distal anastomosis(es), the kidney is returned to the renal fossa, and the proximal anastomosis to the aorta is completed. The renal vein is then reattached, thus completing revascularization of the kidney. We report our experience with five orthotopic ex vivo renal artery reconstructions. Indications for the procedure, details of the technique, and expected results are discussed.
 ...
PMID:Orthotopic ex vivo renal artery reconstruction. 794 48

Comparative analysis of two types of ureterocystic anastomosis in kidney transplantation showed the advantages and shortcomings of the method developed at the Moscow Regional Scientific Research Clinical Institute. The new anastomosis fundamentally differs from the traditional Mebel-Shumakov method in the absence of sutures between the ureter and the bladder mucosa. This feature makes it possible to avoid injury to the bladder mucosa which is often changed in prolonged anuria and reduce the edema and ischemia of the terminal part of the ureteral graft. This facilitates adaptation of the anastomosis to polyuria which often occurs in the early postoperative period. The relatively simple techniques shortens the time needed for the operation. These advantages of the new method of ureterocystotomy are manifested by decrease of the total number of urological complications and the relative incidence of serious early urological complications like fistula of the ureterocystic anastomosis and necrosis of the ureter which most often lead to loss of the transplant and sometimes to death of the patient. The use of the anastomosis developed at the Clinical Institute, however, is attended by a relatively high incidence of ureteral stricture in the late-term postoperative period, evidently due to prolonged contact of urine with the bladder muscular coat and the ureteral adventitia. Thus, the more favorable results of ureterocystic anastomosis formed by the method developed at the Clinical Institute allow it to be recommended for further use in kidney transplantation.
 ...
PMID:[Comparative evaluation of two methods for the uretero-cystic anastomosis]. 796 93

An effective and ultrarapid technique for kidney transplantation in the rat is introduced. In this manner, physiological and immunological parameters could be tested without difficulty in small animals such as the rat. Shorter periods of warm ischemia were achieved by rapid harvesting and anastomotic times using a combination of the sleeve technique for the artery, a cuff technique for the vein, and the over-a-stem technique for the ureter. In 20 rats, total vascular (artery and vein) anastomotic times were 5.35 +/- 0.59 min, of which the artery was 4.30 +/- 0.40 minutes and the vein was 1.05 +/- 0.20 min. The ureter anastomotic time was 1.0 +/- 0.1 min. The surgical complications were three ureteral stenoses. The 15 day survival was 100%. Plasma creatinine and histological findings at 24 and 30 days after transplantation were within normal limits with no evidence of ischemic damage. The advantage of this technique is its effectivity and simplicity that allows for reduced times of warm ischemia. This is the fastest technique published so far in the literature. We propose this technique to be employed in all studies of kidney transplantation and preservation in the rat.
 ...
PMID:Ultrarapid orthotopic technique for renal transplantation in the rat. 803 75

This paper describes a novel technique using the blood flow tracer C14-iodoantipyrine to measure ureteric blood flow in anesthetized Sprague-Dawley rats. The ureters were divided into five equal segments, and the blood flow was measured using a modification of the Fick principle. There was a gradient down the ureter with a significant difference between upper (159 ml./100 gm./min.) and lower (83 ml./100 gm./min.) ureteric segmental blood flows. This technique may allow the role of ureteric ischemia to be investigated in a variety of disease states.
 ...
PMID:Radiotracer measurement of ureteric blood flow. 805 26

Rat experiments demonstrated that cystamine showed a dose-dependent effect in renal ischemia. Ischemia was induced by ligation of renal vessels and the ureter for 90 minutes. Unithiol given in a single dose before ischemia produced no protective effect. Preadministration of sodium nitrite in doses causing slight to moderate hemic hypoxia could not diminish reoxygenation ischemic lesions.
 ...
PMID:[The action of sulfur-containing and methemoglobin-forming compounds in renal ischemia]. 831 3

Pyeloureterostomy is the standard procedure for reconstructing renal allograft ureteral complications. Most reports describe an end-to-end technique with or without native nephrectomy. An alternative is an end-to-side anastomosis, leaving the native ureter in continuity. We report our experience with the latter method. Since July 1983, 437 renal transplantations have been performed at our institution. End-to-side pyeloureterostomy has been used in 5 cases for urological reconstruction after renal transplantation following ureteral ischemic necrosis or stenosis. In 1 patient the native kidneys had been removed several years previously but in the remaining 4 the native kidneys were left in situ. There have been no significant complications following this procedure. We believe that by not significantly mobilizing, ligating or dividing the native ureter the chance of anastomotic breakdown due to ischemia may be decreased.
 ...
PMID:Pyeloureterostomy in the management of renal allograft ureteral complications: an alternative technique. 842 22

A protective action of lasix, dichlothiazide, and triampur (dichlothiazide + triamterene) was studied in experiments on rats. Ischemia was simulated by obstruction of kidney vessels and ureter for 90 min. Lasix and dichlothiazide produced a protective effect in renal ischemia and at the same time resulted decrease of lifetime of experimental rats. Triampur increased the lifetime and decreased the losses of potassium in kidney tissue.
 ...
PMID:[The action of diuretics in renal ischemia]. 870 84

BMP-7, a member of the bone morphogenic protein subfamily (BMPs) of the transforming growth factor-beta superfamily of secreted growth factors, is abundantly expressed in the fetal kidney. The precise role of this protein in renal physiology or pathology is unknown. A cDNA that encodes rat BMP-7 was cloned and used as a probe to localize BMP-7 mRNA expression by in situ hybridization in the adult rat kidney. The highest expression of BMP-7 mRNA could be seen in tubules of the outer medulla. In glomeruli, a few cells, mainly located at the periphery of the glomerular tuft, showed specific and strong signals. Also, high BMP-7 mRNA expression could be localized to the adventitia of renal arteries, as well as to the epithelial cell layer of the renal pelvis and the ureter. Preliminary evidence suggests that BMP-7 enhances recovery when infused into rats with ischemia-induced acute renal failure. We examined BMP-7 mRNA expression in kidneys with acute renal failure induced by unilateral renal artery clamping. BMP-7 mRNA abundance as analyzed by solution hybridization was reduced in ischemic kidneys after 6 and 16 h of reperfusion compared with the contralateral kidney. In situ hybridization in ischemic kidneys showed a marked decrease of BMP-7 mRNA in the outer medulla and in glomeruli. Utilizing rat metanephric mesenchymal cells in culture, we also demonstrate that BMP-7 induces epithelial cell differentiation. Taken together, these data suggest that BMP-7 is important in both stimulating and maintaining a healthy differentiated epithelial cell phenotype.
 ...
PMID:Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney. 1007 Jan 61

A clinical analysis was performed in 88 patients with ureteral obstruction. Causes having made the origination of recurrent ureteral obstruction occur were stricture (n = 59) and vesicoureteral reflux (VUR). Origination of the stricture of the ureter was caused by scar and sclerotic changes in its wall and neoimplanted ostium. Causes of VUR origination included surgical techniques that do not envisage creation of antireflux defence for the ureter and insufficiently complete removal of the pathology at the supra- and infravesical levels. Causes of unsatisfactory results of treatment of megaureter after ileoplastics of the ureter included neglect of creation of antireflux mechanisms of defence for the upper urinary tract, ischemia of distal segments of transplants and of the ureter.
 ...
PMID:[The cause of recurrent ureteral obstruction]. 1062 47


<< Previous 1 2 3 4 5 6 7 Next >>